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abstractpubmed· Abstract 2016· item PMID:27217711

von Willebrand factor antigen as a therapeutic target of portal hypertension in cirrhosis. Increased thrombotic potential within the liver sinusoids due to local endothelial production of von Willebrand factor antigen macromolecules could represent an additional therapeutic target of portal hypertension in patients with cirrhosis. In this case, anti-inflammatory and antithrombotic drugs could modulate portal pressure by preventing the formation of intrahepatic platelet-induced microthrombi.