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abstractpubmed· Abstract 2021· item PMID:33326565

Mechanisms of Colonization Resistance Against Clostridioides difficile. Clostridioides difficile is an urgent antimicrobial-resistant bacterium, causing mild to moderate and sometimes life-threatening disease. Commensal gut microbes are critical for providing colonization resistance against C difficile and can be leveraged as non-antibiotic alternative therapeutics for the prevention and treatment of C difficile infection.