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abstractpubmed· Abstract 2021· item PMID:34779084

Circulating Fibrocyte Level in Children with Cystic Fibrosis. BACKGROUND: This study aimed to evaluate circulating fibrocyte levels of cystic fibrosis (CF) patients at stable and exacerbation period. METHODS: The study group consisted of 39 patients diagnosed with CF and 20 healthy controls. Individuals included in the study were divided into 3 groups as CF, CF exacerbated and healthy control groups and their circulating fibrocyte levels were compared. Findings from pulmonary function test (PFT) and high-resolution computed tomography (HRCT) of the lung were evaluated and compared with each other. RESULTS: The circulating fibrocyte count was found significantly higher in patients with CF compared to the exacerbated and control groups. No correlation was found between the forced expiratory volume in 1 second (%FEV1 ) and forced vital capacity (%FVC) values in PFT and the circulating fibrocyte count. The circulating fibrocyte count in patients (in CF group) with positive findings in HRCT was statistically significantly lower. CONCLUSION: The circulating fibrocyte level in the peripheral blood of the patients with CF was increased.