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Understanding Unicameral and Aneurysmal Bone Cysts. Bone cysts in the pediatric population are often found incidentally on radiographs or after a cyst has created cortical weakness leading to a pathologic fracture. Most bone cysts are benign, are pain free, and resolve spontaneously. The most common bone cyst is unicameral 1-chamber bone cyst, also known as simple bone cyst. General practice pediatricians may be the first to encounter these lesions, and this article aims to help elucidate their incidence, etiology, clinical findings, radiologic findings, and modern treatment approaches. The other differential diagnoses that should be considered, specifically, aneurysmal bone cyst, are also explored. This summary is not all inclusive, and it is recommended that all patients be referred to a pediatric orthopedist.