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Walk the evidence base by book and chapter — the raw source passages that ground Ask, Differential, and the rest.
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abstractpubmed· Abstract 2016· item PMID:27328301
Why Most Clinical Research Is Not Useful. John Ioannidis argues that problem base, context placement, information gain, pragmatism, patient centeredness, value for money, feasibility, and transparency define useful clinical research. He suggests most clinical research is not useful and reform is overdue.