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Vulvodynia: Diagnosis and Management. Vulvodynia is a common condition that negatively affects sexual health and quality of life for many women. A new classification system has been adopted that divides vulvodynia into subtypes based on pain characteristics. Diagnosis relies on ruling out possible contributing pathologic conditions. A multidisciplinary approach to treatment is likely to achieve the best outcome for all types. Medical therapy with systemic neuromodulators is suggested for generalized vulvodynia. For patients with vestibulodynia, topical therapy may be beneficial. Vestibulectomy has a high success rate and may be a good option if the patient is not responding to treatment.