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Walk the evidence base by book and chapter — the raw source passages that ground Ask, Differential, and the rest.

• (untitled)1 passage
• 100 years of insulin: celebrating the past, present and future of diabetes therapy.1 passage
• 3K3A-activated protein C stimulates postischemic neuronal repair by human neural stem cells in mice.1 passage
• 4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors.1 passage
• A C-terminal HSP90 inhibitor restores glucocorticoid sensitivity and relieves a mouse allograft model of Cushing disease.1 passage
• A CD41 passage
• A MYC-aurora kinase A protein complex represents an actionable drug target in p53-altered liver cancer.1 passage
• A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity.1 passage
• A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence.1 passage
• A biobank of patient-derived pediatric brain tumor models.1 passage
• A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance.1 passage
• A calcium- and calpain-dependent pathway determines the response to lenalidomide in myelodysplastic syndromes.1 passage
• A case report of clonal EBV-like memory CD41 passage
• A cellular census of human lungs identifies novel cell states in health and in asthma.1 passage
• A chimeric hemagglutinin-based universal influenza virus vaccine approach induces broad and long-lasting immunity in a randomized, placebo-controlled phase I trial.1 passage
• A clinically meaningful metric of immune age derived from high-dimensional longitudinal monitoring.1 passage
• A clonal expression biomarker associates with lung cancer mortality.1 passage
• A combined risk score enhances prediction of type 1 diabetes among susceptible children.1 passage
• A controlled human Schistosoma mansoni infection model to advance novel drugs, vaccines and diagnostics.1 passage
• A critical analysis of the neurodevelopmental and neurosensory outcomes after 2 years for children with in utero Zika virus exposure.1 passage
• A deep learning system for differential diagnosis of skin diseases.1 passage
• A digital biomarker of diabetes from smartphone-based vascular signals.1 passage
• A distinct innate lymphoid cell population regulates tumor-associated T cells.1 passage
• A dynamic COVID-19 immune signature includes associations with poor prognosis.1 passage
• A framework for microbiome science in public health.1 passage
• A framework for the investigation of rare genetic disorders in neuropsychiatry.1 passage
• A framework for understanding and targeting residual disease in oncogene-driven solid cancers.1 passage
• A fully human transgene switch to regulate therapeutic protein production by cooling sensation.1 passage
• A genome-editing strategy to treat β-hemoglobinopathies that recapitulates a mutation associated with a benign genetic condition.1 passage
• A global survey of potential acceptance of a COVID-19 vaccine.1 passage
• A guide to deep learning in healthcare.1 passage
• A high-fidelity Cas9 mutant delivered as a ribonucleoprotein complex enables efficient gene editing in human hematopoietic stem and progenitor cells.1 passage
• A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication.1 passage
• A highly potent long-acting small-molecule HIV-1 capsid inhibitor with efficacy in a humanized mouse model.1 passage
• A histone deacetylase 3-dependent pathway delimits peripheral myelin growth and functional regeneration.1 passage
• A human APOC3 missense variant and monoclonal antibody accelerate apoC-III clearance and lower triglyceride-rich lipoprotein levels.1 passage
• A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism.1 passage
• A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance.1 passage
• A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite.1 passage
• A human three-dimensional neural-perivascular 'assembloid' promotes astrocytic development and enables modeling of SARS-CoV-2 neuropathology.1 passage
• A human-specific AS3MT isoform and BORCS7 are molecular risk factors in the 10q24.32 schizophrenia-associated locus.1 passage
• A humanized bone marrow ossicle xenotransplantation model enables improved engraftment of healthy and leukemic human hematopoietic cells.1 passage
• A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.1 passage
• A longitudinal big data approach for precision health.1 passage
• A luminal unfolding microneedle injector for oral delivery of macromolecules.1 passage
• A maternal serum metabolite ratio predicts fetal growth restriction at term.1 passage
• A mouse model for embryonal tumors with multilayered rosettes uncovers the therapeutic potential of Sonic-hedgehog inhibitors.1 passage
• A multiclade env-gag VLP mRNA vaccine elicits tier-2 HIV-1-neutralizing antibodies and reduces the risk of heterologous SHIV infection in macaques.1 passage
• A multidimensional precision medicine approach identifies an autism subtype characterized by dyslipidemia.1 passage
• A natural killer-dendritic cell axis defines checkpoint therapy-responsive tumor microenvironments.1 passage
• A neuroimaging biomarker for striatal dysfunction in schizophrenia.1 passage
• A neuroimaging biomarker for sustained experimental and clinical pain.1 passage
• A novel chimeric antigen receptor containing a JAK-STAT signaling domain mediates superior antitumor effects.1 passage
• A patient-level pooled analysis of treatment-shortening regimens for drug-susceptible pulmonary tuberculosis.1 passage
• A peripheral immune signature of responsiveness to PD-1 blockade in patients with classical Hodgkin lymphoma.1 passage
• A phase 1 trial of lipid-encapsulated mRNA encoding a monoclonal antibody with neutralizing activity against Chikungunya virus.1 passage
• A phase 1/2 trial of an immune-modulatory vaccine against IDO/PD-L1 in combination with nivolumab in metastatic melanoma.1 passage
• A population-based phenome-wide association study of cardiac and aortic structure and function.1 passage
• A public antibody lineage that potently inhibits malaria infection through dual binding to the circumsporozoite protein.1 passage
• A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice.1 passage
• A randomized proof-of-mechanism trial applying the 'fast-fail' approach to evaluating κ-opioid antagonism as a treatment for anhedonia.1 passage
• A rapid pro-hemostatic approach to overcome direct oral anticoagulants.1 passage
• A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents.1 passage
• A rectal cancer organoid platform to study individual responses to chemoradiation.1 passage
• A safe and potent anti-CD19 CAR T cell therapy.1 passage
• A selective BCL-X1 passage
• A serological assay to detect SARS-CoV-2 seroconversion in humans.1 passage
• A signature of circulating inflammatory proteins and development of end-stage renal disease in diabetes.1 passage
• A single T cell epitope drives the neutralizing anti-drug antibody response to natalizumab in multiple sclerosis patients.1 passage
• A single dose of neoadjuvant PD-1 blockade predicts clinical outcomes in resectable melanoma.1 passage
• A single injection of crystallizable fragment domain-modified antibodies elicits durable protection from SHIV infection.1 passage
• A single-cell and single-nucleus RNA-Seq toolbox for fresh and frozen human tumors.1 passage
• A single-cell atlas of the peripheral immune response in patients with severe COVID-19.1 passage
• A single-cell landscape of high-grade serous ovarian cancer.1 passage
• A single-cell map of intratumoral changes during anti-PD1 treatment of patients with breast cancer.1 passage
• A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.1 passage
• A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment.1 passage
• A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer's disease.1 passage
• A stemness-related ZEB1-MSRB3 axis governs cellular pliancy and breast cancer genome stability.1 passage
• A stochastic agent-based model of the SARS-CoV-2 epidemic in France.1 passage
• A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress.1 passage
• A targeted antisense therapeutic approach for Hutchinson-Gilford progeria syndrome.1 passage
• A transcriptionally and functionally distinct PD-11 passage
• A trial of gantenerumab or solanezumab in dominantly inherited Alzheimer's disease.1 passage
• A tripartite complex of suPAR, APOL1 risk variants and α1 passage
• A validated predictive algorithm of post-traumatic stress course following emergency department admission after a traumatic stressor.1 passage
• ACC inhibitor alone or co-administered with a DGAT2 inhibitor in patients with non-alcoholic fatty liver disease: two parallel, placebo-controlled, randomized phase 2a trials.1 passage
• ACF chromatin-remodeling complex mediates stress-induced depressive-like behavior.1 passage
• APP intracellular domain-WAVE1 pathway reduces amyloid-β production.1 passage
• ARAF recurrent mutation causes central conducting lymphatic anomaly treatable with a MEK inhibitor.1 passage
• ARID1A deficiency promotes mutability and potentiates therapeutic antitumor immunity unleashed by immune checkpoint blockade.1 passage
• Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche.1 passage
• Accounting for sex in the genome.1 passage
• Acquired EGFR C797S mutation mediates resistance to AZD9291 in non-small cell lung cancer harboring EGFR T790M.1 passage
• Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19.1 passage
• Actionable equality.1 passage
• Activating mutations in CSF1R and additional receptor tyrosine kinases in histiocytic neoplasms.1 passage
• Activation of AMPKα2 in adipocytes is essential for nicotine-induced insulin resistance in vivo.1 passage
• Activation of HIF-1α and LL-37 by commensal bacteria inhibits Candida albicans colonization.1 passage
• Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis.1 passage
• Activation of the pluripotency factor OCT4 in smooth muscle cells is atheroprotective.1 passage
• Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer.1 passage
• Acute liver failure is regulated by MYC- and microbiome-dependent programs.1 passage
• Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters.1 passage
• Adaptive evolution of virulence and persistence in carbapenem-resistant Klebsiella pneumoniae.1 passage
• Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation.1 passage
• Adipose lipid turnover and long-term changes in body weight.1 passage
• Adipsin preserves beta cells in diabetic mice and associates with protection from type 2 diabetes in humans.1 passage
• Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer's disease.1 passage
• Advancing the understanding of autism disease mechanisms through genetics.1 passage
• Age and generational patterns of overdose death risk from opioids and other drugs.1 passage
• Age-dependent effects in the transmission and control of COVID-19 epidemics.1 passage
• Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1.1 passage
• Allele-selective transcriptional repression of mutant HTT for the treatment of Huntington's disease.1 passage
• Allele-specific gene editing prevents deafness in a model of dominant progressive hearing loss.1 passage
• Altered neuronal migratory trajectories in human cerebral organoids derived from individuals with neuronal heterotopia.1 passage
• Altered perivascular fibroblast activity precedes ALS disease onset.1 passage
• Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation.1 passage
• An AKT3-FOXG1-reelin network underlies defective migration in human focal malformations of cortical development.1 passage
• An ALOX12-12-HETE-GPR31 signaling axis is a key mediator of hepatic ischemia-reperfusion injury.1 passage
• An RNAi therapeutic targeting antithrombin to rebalance the coagulation system and promote hemostasis in hemophilia.1 passage
• An adaptive, biomarker-directed platform study of durvalumab in combination with targeted therapies in advanced urothelial cancer.1 passage
• An algorithmic approach to reducing unexplained pain disparities in underserved populations.1 passage
• An approach to suppress the evolution of resistance in BRAF1 passage
• An asthma-associated IL4R variant exacerbates airway inflammation by promoting conversion of regulatory T cells to TH17-like cells.1 passage
• An augmented reality microscope with real-time artificial intelligence integration for cancer diagnosis.1 passage
• An emerging role for neutrophil extracellular traps in noninfectious disease.1 passage
• An ensemble of neural networks provides expert-level prenatal detection of complex congenital heart disease.1 passage
• An ex vivo tumor fragment platform to dissect response to PD-1 blockade in cancer.1 passage
• An immune-beige adipocyte communication via nicotinic acetylcholine receptor signaling.1 passage
• An immune-cell signature of bacterial sepsis.1 passage
• An inflammatory cytokine signature predicts COVID-19 severity and survival.1 passage
• An inhibitor of oxidative phosphorylation exploits cancer vulnerability.1 passage
• An oncogenic Ezh2 mutation induces tumors through global redistribution of histone 3 lysine 27 trimethylation.1 passage
• An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity.1 passage
• Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes.1 passage
• Anatomical and functional dichotomy of ocular itch and pain.1 passage
• Anemia prevalence in women of reproductive age in low- and middle-income countries between 2000 and 2018.1 passage
• Anemia: progress in molecular mechanisms and therapies.1 passage
• Anomalously warm temperatures are associated with increased injury deaths.1 passage
• Antagonism of PPAR-γ signaling expands human hematopoietic stem and progenitor cells by enhancing glycolysis.1 passage
• Anti-GD2 CAR-NKT cells in patients with relapsed or refractory neuroblastoma: an interim analysis.1 passage
• Antibody 10-1074 suppresses viremia in HIV-1-infected individuals.1 passage
• Antibody responses to SARS-CoV-2 in patients with COVID-19.1 passage
• Antibody responses to the BNT162b2 mRNA vaccine in individuals previously infected with SARS-CoV-2.1 passage
• Antibody-mediated inhibition of GDF15-GFRAL activity reverses cancer cachexia in mice.1 passage
• Antidepressive effects of targeting ELK-1 signal transduction.1 passage
• Antigen discovery and specification of immunodominance hierarchies for MHCII-restricted epitopes.1 passage
• Antigen-independent activation enhances the efficacy of 4-1BB-costimulated CD22 CAR T cells.1 passage
• Antimalarial drug resistance: linking Plasmodium falciparum parasite biology to the clinic.1 passage
• Antitumor activity of an engineered decoy receptor targeting CLCF1-CNTFR signaling in lung adenocarcinoma.1 passage
• Antitumor activity of crizotinib in lung cancers harboring a MET exon 14 alteration.1 passage
• ApoE attenuates unresolvable inflammation by complex formation with activated C1q.1 passage
• Apoptosis inhibitor of macrophage protein enhances intraluminal debris clearance and ameliorates acute kidney injury in mice.1 passage
• Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA interference-based bone anabolic strategy.1 passage
• Aramchol in patients with nonalcoholic steatohepatitis: a randomized, double-blind, placebo-controlled phase 2b trial.1 passage
• Articular cartilage regeneration by activated skeletal stem cells.1 passage
• Artificial intelligence-enabled electrocardiograms for identification of patients with low ejection fraction: a pragmatic, randomized clinical trial.1 passage
• Artificial intelligence-enabled rapid diagnosis of patients with COVID-19.1 passage
• Asprosin is a centrally acting orexigenic hormone.1 passage
• Assessment of cognitive and neural recovery in survivors of pediatric brain tumors in a pilot clinical trial using metformin.1 passage
• Assessment of medication self-administration using artificial intelligence.1 passage
• Association of lead-exposure risk and family income with childhood brain outcomes.1 passage
• Atezolizumab plus cobimetinib and vemurafenib in BRAF-mutated melanoma patients.1 passage
• Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis.1 passage
• Attributes and predictors of long COVID.1 passage
• Aurora kinase A drives the evolution of resistance to third-generation EGFR inhibitors in lung cancer.1 passage
• Autism risk in offspring can be assessed through quantification of male sperm mosaicism.1 passage
• Autoimmunity against a defective ribosomal insulin gene product in type 1 diabetes.1 passage
• Automated deep-neural-network surveillance of cranial images for acute neurologic events.1 passage
• Automated opportunistic osteoporotic fracture risk assessment using computed tomography scans to aid in FRAX underutilization.1 passage
• Avelumab maintenance in advanced urothelial carcinoma: biomarker analysis of the phase 3 JAVELIN Bladder 100 trial.1 passage
• Avelumab plus axitinib versus sunitinib in advanced renal cell carcinoma: biomarker analysis of the phase 3 JAVELIN Renal 101 trial.1 passage
• Avoidable flaws in observational analyses: an application to statins and cancer.1 passage
• Axes of a revolution: challenges and promises of big data in healthcare.1 passage
• BL-8040, a CXCR4 antagonist, in combination with pembrolizumab and chemotherapy for pancreatic cancer: the COMBAT trial.1 passage
• BNT162b2 and mRNA-1273 COVID-19 vaccine effectiveness against the SARS-CoV-2 Delta variant in Qatar.1 passage
• BRAF1 passage
• BRAF somatic mutation contributes to intrinsic epileptogenicity in pediatric brain tumors.1 passage
• Bacterial and host determinants of cough aerosol culture positivity in patients with drug-resistant versus drug-susceptible tuberculosis.1 passage
• Beneficial effects on vision in patients undergoing retinal gene therapy for choroideremia.1 passage
• Big data meets mechanism.1 passage
• Biochemical autoregulatory gene therapy for focal epilepsy.1 passage
• Biodistribution of onasemnogene abeparvovec DNA, mRNA and SMN protein in human tissue.1 passage
• Biology and evolution of poorly differentiated neuroendocrine tumors.1 passage
• Biomarkers for neurodegenerative diseases.1 passage
• Biomedical research: lessons from the last decade's crisis and austerity-stricken small countries for the current COVID-19-related crisis.1 passage
• Biomimetic 3D-printed scaffolds for spinal cord injury repair.1 passage
• Bispecific anti-CD20, anti-CD19 CAR T cells for relapsed B cell malignancies: a phase 1 dose escalation and expansion trial.1 passage
• Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson's disease.1 passage
• Blocking c-Met-mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors.1 passage
• Blood-based tumor mutational burden as a predictor of clinical benefit in non-small-cell lung cancer patients treated with atezolizumab.1 passage
• Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction.1 passage
• Bone marrow niche trafficking of miR-126 controls the self-renewal of leukemia stem cells in chronic myelogenous leukemia.1 passage
• Brain somatic mutations in MTOR cause focal cortical dysplasia type II leading to intractable epilepsy.1 passage
• Broad immune activation underlies shared set point signatures for vaccine responsiveness in healthy individuals and disease activity in patients with lupus.1 passage
• Broadly neutralizing anti-HIV-1 monoclonal antibodies in the clinic.1 passage
• Brown adipose tissue is associated with cardiometabolic health.1 passage
• Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity.1 passage
• CAR T cell-induced cytokine release syndrome is mediated by macrophages and abated by IL-1 blockade.1 passage
• CAR T cells with dual targeting of CD19 and CD22 in adult patients with recurrent or refractory B cell malignancies: a phase 1 trial.1 passage
• CAR T cells with dual targeting of CD19 and CD22 in pediatric and young adult patients with relapsed or refractory B cell acute lymphoblastic leukemia: a phase 1 trial.1 passage
• CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands.1 passage
• CAUSEL: an epigenome- and genome-editing pipeline for establishing function of noncoding GWAS variants.1 passage
• CCR5-∆32 is deleterious in the homozygous state in humans.1 passage
• CD22-targeted CAR T cells induce remission in B-ALL that is naive or resistant to CD19-targeted CAR immunotherapy.1 passage
• CD47 blockade triggers T cell-mediated destruction of immunogenic tumors.1 passage
• CD81 passage
• COVID-19 dynamics after a national immunization program in Israel.1 passage
• COVID-19 in Amazonas, Brazil, was driven by the persistence of endemic lineages and P.1 emergence.1 passage
• COVID-19 vaccine acceptance and hesitancy in low- and middle-income countries.1 passage
• CRISPR-Cas9 genome editing induces a p53-mediated DNA damage response.1 passage
• CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma.1 passage
• Cabozantinib for neurofibromatosis type 1-related plexiform neurofibromas: a phase 2 trial.1 passage
• Can aging be 'drugged'?1 passage
• Cancer cells exploit an orphan RNA to drive metastatic progression.1 passage
• Cancer prognosis with shallow tumor RNA sequencing.1 passage
• Cancer stem cells revisited.1 passage
• Capturing the biology of disease severity in a PSC-based model of familial dysautonomia.1 passage
• Carboplatin in BRCA1/2-mutated and triple-negative breast cancer BRCAness subgroups: the TNT Trial.1 passage
• Cardiac RKIP induces a beneficial β-adrenoceptor-dependent positive inotropy.1 passage
• Cardiologist-level arrhythmia detection and classification in ambulatory electrocardiograms using a deep neural network.1 passage
• Cardioprotection and lifespan extension by the natural polyamine spermidine.1 passage
• Caring for patients with cancer in the COVID-19 era.1 passage
• Cartography of opportunistic pathogens and antibiotic resistance genes in a tertiary hospital environment.1 passage
• Caspase-2 cleavage of tau reversibly impairs memory.1 passage
• Causal associations of blood lipids with risk of ischemic stroke and intracerebral hemorrhage in Chinese adults.1 passage
• Cellular and humoral immune responses following SARS-CoV-2 mRNA vaccination in patients with multiple sclerosis on anti-CD20 therapy.1 passage
• Cellular senescence in aging and age-related disease: from mechanisms to therapy.1 passage
• Characteristics of anti-CD19 CAR T cell infusion products associated with efficacy and toxicity in patients with large B cell lymphomas.1 passage
• Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding.1 passage
• Characterization of pancreatic NMDA receptors as possible drug targets for diabetes treatment.1 passage
• Characterization of pre-existing and induced SARS-CoV-2-specific CD81 passage
• Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-[1 passage
• Chemical corrector treatment ameliorates increased seizure susceptibility in a mouse model of familial epilepsy.1 passage
• Chemotherapy-induced ileal crypt apoptosis and the ileal microbiome shape immunosurveillance and prognosis of proximal colon cancer.1 passage
• Childhood amyotrophic lateral sclerosis caused by excess sphingolipid synthesis.1 passage
• Choosing Wisely for COVID-19: ten evidence-based recommendations for patients and physicians.1 passage
• Chromatin immunoprecipitation from fixed clinical tissues reveals tumor-specific enhancer profiles.1 passage
• Chromatin regulators mediate anthracycline sensitivity in breast cancer.1 passage
• Chromosome 1q21.3 amplification is a trackable biomarker and actionable target for breast cancer recurrence.1 passage
• Chronic inflammation in the etiology of disease across the life span.1 passage
• Circulating tumor DNA-guided treatment with pertuzumab plus trastuzumab for HER2-amplified metastatic colorectal cancer: a phase 2 trial.1 passage
• Classification and characterization of microsatellite instability across 18 cancer types.1 passage
• Classification and mutation prediction from non-small cell lung cancer histopathology images using deep learning.1 passage
• Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice.1 passage
• Cleavage of Na(+) channels by calpain increases persistent Na(+) current and promotes spasticity after spinal cord injury.1 passage
• Clinical activity and molecular correlates of response to atezolizumab alone or in combination with bevacizumab versus sunitinib in renal cell carcinoma.1 passage
• Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections.1 passage
• Clinical and virologic characteristics of the first 12 patients with coronavirus disease 2019 (COVID-19) in the United States.1 passage
• Clinical efficacy and biomarker analysis of neoadjuvant atezolizumab in operable urothelial carcinoma in the ABACUS trial.1 passage
• Clinical evolution, genetic landscape and trajectories of clonal hematopoiesis in SAMD9/SAMD9L syndromes.1 passage
• Clinical genome sequencing uncovers potentially targetable truncations and fusions of MAP3K8 in spitzoid and other melanomas.1 passage
• Clinical integration of machine learning for curative-intent radiation treatment of patients with prostate cancer.1 passage
• Clinical lessons learned from the first leg of the CAR T cell journey.1 passage
• Clinical translation of a high-performance neural prosthesis.1 passage
• Clinical utility of circulating tumor DNA sequencing in advanced gastrointestinal cancer: SCRUM-Japan GI-SCREEN and GOZILA studies.1 passage
• Clinical-grade computational pathology using weakly supervised deep learning on whole slide images.1 passage
• Clinically applicable deep learning for diagnosis and referral in retinal disease.1 passage
• Clonal CD41 passage
• Clonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes.1 passage
• Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients.1 passage
• Clonal heterogeneity of acute myeloid leukemia treated with the IDH2 inhibitor enasidenib.1 passage
• Clonal replacement of tumor-specific T cells following PD-1 blockade.1 passage
• Closed-loop neuromodulation in an individual with treatment-resistant depression.1 passage
• Clustering and superspreading potential of SARS-CoV-2 infections in Hong Kong.1 passage
• Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive thermogenesis.1 passage
• Cold-induced epigenetic programming of the sperm enhances brown adipose tissue activity in the offspring.1 passage
• Colibactin DNA-damage signature indicates mutational impact in colorectal cancer.1 passage
• Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing.1 passage
• Combating COVID-19: health equity matters.1 passage
• Combination anti-HIV-1 antibody therapy is associated with increased virus-specific T cell immunity.1 passage
• Combination inhibition of PI3K and mTORC1 yields durable remissions in mice bearing orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases.1 passage
• Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer.1 passage
• Combinatorial inhibition of PTPN12-regulated receptors leads to a broadly effective therapeutic strategy in triple-negative breast cancer.1 passage
• Combined BRAF and MEK inhibition with PD-1 blockade immunotherapy in BRAF-mutant melanoma.1 passage
• Combined PD-1, BRAF and MEK inhibition in advanced BRAF-mutant melanoma: safety run-in and biomarker cohorts of COMBI-i.1 passage
• Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma.1 passage
• Combined inhibition of DDR1 and Notch signaling is a therapeutic strategy for KRAS-driven lung adenocarcinoma.1 passage
• Combined landscape of single-nucleotide variants and copy number alterations in clonal hematopoiesis.1 passage
• Combined mutation in Vhl, Trp53 and Rb1 causes clear cell renal cell carcinoma in mice.1 passage
• Common clonal origin of central and resident memory T cells following skin immunization.1 passage
• Common germline variants of the human APOE gene modulate melanoma progression and survival.1 passage
• Community ecology as a framework for human microbiome research.1 passage
• Community-level evidence for SARS-CoV-2 vaccine protection of unvaccinated individuals.1 passage
• Comprehensive molecular characterization of clinical responses to PD-1 inhibition in metastatic gastric cancer.1 passage
• Congenital Zika virus infection as a silent pathology with loss of neurogenic output in the fetal brain.1 passage
• Continuous versus intermittent BRAF and MEK inhibition in patients with BRAF-mutated melanoma: a randomized phase 2 trial.1 passage
• Contribution of genetics to visceral adiposity and its relation to cardiovascular and metabolic disease.1 passage
• Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial.1 passage
• Convalescent plasma treatment of severe COVID-19: a propensity score-matched control study.1 passage
• Convergence of placenta biology and genetic risk for schizophrenia.1 passage
• Cooperative targeting of melanoma heterogeneity with an AXL antibody-drug conjugate and BRAF/MEK inhibitors.1 passage
• Correlates of protection against symptomatic and asymptomatic SARS-CoV-2 infection.1 passage
• Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits.1 passage
• Crowding and the shape of COVID-19 epidemics.1 passage
• Current and future influenza vaccines.1 passage
• Current understanding of the human microbiome.1 passage
• Cytokine release syndrome in a patient with colorectal cancer after vaccination with BNT162b2.1 passage
• Cytoplasmic p53 couples oncogene-driven glucose metabolism to apoptosis and is a therapeutic target in glioblastoma.1 passage
• Cytotoxic CD81 passage
• D-mannose induces regulatory T cells and suppresses immunopathology.1 passage
• DKK2 imparts tumor immunity evasion through β-catenin-independent suppression of cytotoxic immune-cell activation.1 passage
• DNA methylation heterogeneity defines a disease spectrum in Ewing sarcoma.1 passage
• DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling.1 passage
• DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia.1 passage
• Dabrafenib, trametinib and pembrolizumab or placebo in BRAF-mutant melanoma.1 passage
• Dalpiciclib or placebo plus fulvestrant in hormone receptor-positive and HER2-negative advanced breast cancer: a randomized, phase 3 trial.1 passage
• Danuglipron (PF-06882961) in type 2 diabetes: a randomized, placebo-controlled, multiple ascending-dose phase 1 trial.1 passage
• De novo NAD1 passage
• Deaths in children and young people in England after SARS-CoV-2 infection during the first pandemic year.1 passage
• Deciphering the genomic, epigenomic, and transcriptomic landscapes of pre-invasive lung cancer lesions.1 passage
• Dectin 1 activation on macrophages by galectin 9 promotes pancreatic carcinoma and peritumoral immune tolerance.1 passage
• Deep learning can predict microsatellite instability directly from histology in gastrointestinal cancer.1 passage
• Deep learning in histopathology: the path to the clinic.1 passage
• Deep learning models for electrocardiograms are susceptible to adversarial attack.1 passage
• Deep learning of HIV field-based rapid tests.1 passage
• Deep learning-based classification of mesothelioma improves prediction of patient outcome.1 passage
• Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development.1 passage
• Defective proviruses rapidly accumulate during acute HIV-1 infection.1 passage
• Deficiency of the hepatokine selenoprotein P increases responsiveness to exercise in mice through upregulation of reactive oxygen species and AMP-activated protein kinase in muscle.1 passage
• Defining total-body AIDS-virus burden with implications for curative strategies.1 passage
• Delayed childhood neurodevelopment and neurosensory alterations in the second year of life in a prospective cohort of ZIKV-exposed children.1 passage
• Delayed production of neutralizing antibodies correlates with fatal COVID-19.1 passage
• Dentate granule cell recruitment of feedforward inhibition governs engram maintenance and remote memory generalization.1 passage
• Depicting the composition of gut microbiota in a population with varied ethnic origins but shared geography.1 passage
• Designing stem-cell-based dopamine cell replacement trials for Parkinson's disease.1 passage
• Detection and discrimination of intracranial tumors using plasma cell-free DNA methylomes.1 passage
• Detection of collagens by multispectral optoacoustic tomography as an imaging biomarker for Duchenne muscular dystrophy.1 passage
• Detection of colorectal polyps in humans using an intravenously administered fluorescent peptide targeted against c-Met.1 passage
• Detection of renal cell carcinoma using plasma and urine cell-free DNA methylomes.1 passage
• Determinants of COVID-19 disease severity in patients with cancer.1 passage
• Determinants of HIV-1 broadly neutralizing antibody induction.1 passage
• Developing neoantigen-targeted T cell-based treatments for solid tumors.1 passage
• Developing specific reporting guidelines for diagnostic accuracy studies assessing AI interventions: The STARD-AI Steering Group.1 passage
• Development and validation of serological markers for detecting recent Plasmodium vivax infection.1 passage
• Development of a CRISPR/Cas9-based therapy for Hutchinson-Gilford progeria syndrome.1 passage
• Development of a gene-editing approach to restore vision loss in Leber congenital amaurosis type 10.1 passage
• Development of a human skin commensal microbe for bacteriotherapy of atopic dermatitis and use in a phase 1 randomized clinical trial.1 passage
• Developmental origins and emerging therapeutic opportunities for childhood cancer.1 passage
• Developmental timing and critical windows for the treatment of psychiatric disorders.1 passage
• Dexamethasone modulates immature neutrophils and interferon programming in severe COVID-19.1 passage
• Diabetes primes neutrophils to undergo NETosis, which impairs wound healing.1 passage
• Diagnosis of Zika virus infection on a nanotechnology platform.1 passage
• Diagnostic value of plasma phosphorylated tau181 in Alzheimer's disease and frontotemporal lobar degeneration.1 passage
• Dietary zinc alters the microbiota and decreases resistance to Clostridium difficile infection.1 passage
• Differential glucose requirement in skin homeostasis and injury identifies a therapeutic target for psoriasis.1 passage
• Digital technologies in the public-health response to COVID-19.1 passage
• Discovery and validation of a personalized risk predictor for incident tuberculosis in low transmission settings.1 passage
• Disease and healthcare burden of COVID-19 in the United States.1 passage
• Disease-specific oligodendrocyte lineage cells arise in multiple sclerosis.1 passage
• Disruption of KMT2D perturbs germinal center B cell development and promotes lymphomagenesis.1 passage
• Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia.1 passage
• Distinct mechanisms of long-term virologic control in two HIV-infected individuals after treatment interruption of anti-retroviral therapy.1 passage
• Distinct phenotype of CD41 passage
• Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis.1 passage
• Distinction of lymphoid and myeloid clonal hematopoiesis.1 passage
• Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer.1 passage
• Diverse genetic-driven immune landscapes dictate tumor progression through distinct mechanisms.1 passage
• Diversifying clinical trials.1 passage
• Do no harm: a roadmap for responsible machine learning for health care.1 passage
• Dual CD4-based CAR T cells with distinct costimulatory domains mitigate HIV pathogenesis in vivo.1 passage
• Dual effects of carbon monoxide on pericytes and neurogenesis in traumatic brain injury.1 passage
• Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell- and patient-derived tumor organoids.1 passage
• Durable vision improvement after a single treatment with antisense oligonucleotide sepofarsen: a case report.1 passage
• Durvalumab compared to maintenance chemotherapy in metastatic breast cancer: the randomized phase II SAFIR02-BREAST IMMUNO trial.1 passage
• Durvalumab with platinum-pemetrexed for unresectable pleural mesothelioma: survival, genomic and immunologic analyses from the phase 2 PrE0505 trial.1 passage
• Dynamic imaging in patients with tuberculosis reveals heterogeneous drug exposures in pulmonary lesions.1 passage
• Dynamic molecular monitoring reveals that SWI-SNF mutations mediate resistance to ibrutinib plus venetoclax in mantle cell lymphoma.1 passage
• Dynamics of genetically engineered hematopoietic stem and progenitor cells after autologous transplantation in humans.1 passage
• Dysregulated ribonucleoprotein granules promote cardiomyopathy in RBM20 gene-edited pigs.1 passage
• Dysregulation of a long noncoding RNA reduces leptin leading to a leptin-responsive form of obesity.1 passage
• EHRs could clarify drug safety in pregnant people.1 passage
• EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas.1 passage
• Early life dynamics of the human gut virome and bacterial microbiome in infants.1 passage
• Early prediction of circulatory failure in the intensive care unit using machine learning.1 passage
• Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques.1 passage
• Early treatment of COVID-19 with anakinra guided by soluble urokinase plasminogen receptor plasma levels: a double-blind, randomized controlled phase 3 trial.1 passage
• Early-life compartmentalization of human T cell differentiation and regulatory function in mucosal and lymphoid tissues.1 passage
• Effect of Delta variant on viral burden and vaccine effectiveness against new SARS-CoV-2 infections in the UK.1 passage
• Effect of a plant-based, low-fat diet versus an animal-based, ketogenic diet on ad libitum energy intake.1 passage
• Effect of an intravitreal antisense oligonucleotide on vision in Leber congenital amaurosis due to a photoreceptor cilium defect.1 passage
• Effect of salt substitution on community-wide blood pressure and hypertension incidence.1 passage
• Effective control of SARS-CoV-2 transmission in Wanzhou, China.1 passage
• Effectiveness of the BNT162b2 mRNA COVID-19 vaccine in pregnancy.1 passage
• Effects of a large-scale social media advertising campaign on holiday travel and COVID-19 infections: a cluster randomized controlled trial.1 passage
• Effects of underfeeding and oral vancomycin on gut microbiome and nutrient absorption in humans.1 passage
• Efficacy and safety of avapritinib in advanced systemic mastocytosis: interim analysis of the phase 2 PATHFINDER trial.1 passage
• Efficacy outcomes in phase 2 and phase 3 randomized controlled trials in rheumatology.1 passage
• Efficient derivation of microglia-like cells from human pluripotent stem cells.1 passage
• Efruxifermin in non-alcoholic steatohepatitis: a randomized, double-blind, placebo-controlled, phase 2a trial.1 passage
• Elevated prenatal anti-Müllerian hormone reprograms the fetus and induces polycystic ovary syndrome in adulthood.1 passage
• Elevated serum interleukin-8 is associated with enhanced intratumor neutrophils and reduced clinical benefit of immune-checkpoint inhibitors.1 passage
• Elimination of large tumors in mice by mRNA-encoded bispecific antibodies.1 passage
• Elucidation of novel 13-series resolvins that increase with atorvastatin and clear infections.1 passage
• Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda.1 passage
• End-to-end lung cancer screening with three-dimensional deep learning on low-dose chest computed tomography.1 passage
• Endogenous antigen processing drives the primary CD4+ T cell response to influenza.1 passage
• Endothelial exocytosis of angiopoietin-2 resulting from CCM3 deficiency contributes to cerebral cavernous malformation.1 passage
• Engineered bacteriophages for treatment of a patient with a disseminated drug-resistant Mycobacterium abscessus.1 passage
• Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system.1 passage
• Engineering transplantable jejunal mucosal grafts using patient-derived organoids from children with intestinal failure.1 passage
• Enhanced CAR T cell expansion and prolonged persistence in pediatric patients with ALL treated with a low-affinity CD19 CAR.1 passage
• Enhancer mapping uncovers phenotypic heterogeneity and evolution in patients with luminal breast cancer.1 passage
• Enhancer signatures stratify and predict outcomes of non-functional pancreatic neuroendocrine tumors.1 passage
• Epithelial calcineurin controls microbiota-dependent intestinal tumor development.1 passage
• Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis.1 passage
• Equitable allocation of COVID-19 vaccines in the United States.1 passage
• Estimating clinical severity of COVID-19 from the transmission dynamics in Wuhan, China.1 passage
• Ethical development of stem-cell-based interventions.1 passage
• Evaluation and accurate diagnoses of pediatric diseases using artificial intelligence.1 passage
• Evaluation of the extended efficacy of the Dengvaxia vaccine against symptomatic and subclinical dengue infection.1 passage
• Evidence for increased breakthrough rates of SARS-CoV-2 variants of concern in BNT162b2-mRNA-vaccinated individuals.1 passage
• Evolution of delayed resistance to immunotherapy in a melanoma responder.1 passage
• Evolution of metastasis revealed by mutational landscapes of chemically induced skin cancers.1 passage
• Evolution of protective human antibodies against Plasmodium falciparum circumsporozoite protein repeat motifs.1 passage
• Evolutionary divergence of HLA class I genotype impacts efficacy of cancer immunotherapy.1 passage
• Excess TGF-β mediates muscle weakness associated with bone metastases in mice.1 passage
• Excessive fatty acid oxidation induces muscle atrophy in cancer cachexia.1 passage
• Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells.1 passage
• Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models.1 passage
• Exome sequencing implicates genetic disruption of prenatal neuro-gliogenesis in sporadic congenital hydrocephalus.1 passage
• Exome-wide evaluation of rare coding variants using electronic health records identifies new gene-phenotype associations.1 passage
• Expanded skin virome in DOCK8-deficient patients.1 passage
• Expansion of primitive human hematopoietic stem cells by culture in a zwitterionic hydrogel.1 passage
• Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states.1 passage
• Extrapulmonary manifestations of COVID-19.1 passage
• Facilitating a culture of responsible and effective sharing of cancer genome data.1 passage
• Farm-like indoor microbiota in non-farm homes protects children from asthma development.1 passage
• Fasting selectively blocks development of acute lymphoblastic leukemia via leptin-receptor upregulation.1 passage
• Fecal dysbiosis in infants with cystic fibrosis is associated with early linear growth failure.1 passage
• Fecal microbial transplantation and fiber supplementation in patients with severe obesity and metabolic syndrome: a randomized double-blind, placebo-controlled phase 2 trial.1 passage
• Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis.1 passage
• Federated learning for predicting clinical outcomes in patients with COVID-19.1 passage
• Fenebrutinib in H1 passage
• Fetal cranial growth trajectories are associated with growth and neurodevelopment at 2 years of age: INTERBIO-21st Fetal Study.1 passage
• Fetal gene therapy for neurodegenerative disease of infants.1 passage
• Fibroblast growth factor 19 regulates skeletal muscle mass and ameliorates muscle wasting in mice.1 passage
• First-dose ChAdOx1 and BNT162b2 COVID-19 vaccines and thrombocytopenic, thromboembolic and hemorrhagic events in Scotland.1 passage
• Four distinct trajectories of tau deposition identified in Alzheimer's disease.1 passage
• Fully automated closed-loop glucose control compared with standard insulin therapy in adults with type 2 diabetes requiring dialysis: an open-label, randomized crossover trial.1 passage
• Functional diversity and cooperativity between subclonal populations of pediatric glioblastoma and diffuse intrinsic pontine glioma cells.1 passage
• Functional precision cancer medicine-moving beyond pure genomics.1 passage
• Functionally defined therapeutic targets in diffuse intrinsic pontine glioma.1 passage
• GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand.1 passage
• GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates.1 passage
• GM-CSF and CXCR4 define a T helper cell signature in multiple sclerosis.1 passage
• Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector.1 passage
• Gain-of-function mutation of microRNA-140 in human skeletal dysplasia.1 passage
• Gene replacement of α-globin with β-globin restores hemoglobin balance in β-thalassemia-derived hematopoietic stem and progenitor cells.1 passage
• Generation of functional lungs via conditional blastocyst complementation using pluripotent stem cells.1 passage
• Genetic and functional characterization of clonally derived adult human brown adipocytes.1 passage
• Genetic deficiency of indoleamine 2,3-dioxygenase promotes gut microbiota-mediated metabolic health.1 passage
• Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness.1 passage
• Genetic mechanisms of target antigen loss in CAR19 therapy of acute lymphoblastic leukemia.1 passage
• Genetic predisposition, modifiable-risk-factor profile and long-term dementia risk in the general population.1 passage
• Genetic testing, insurance discrimination and medical research: what the United States can learn from peer countries.1 passage
• Genetically engineered human cortical spheroid models of tuberous sclerosis.1 passage
• Genital inflammation undermines the effectiveness of tenofovir gel in preventing HIV acquisition in women.1 passage
• Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo.1 passage
• Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors.1 passage
• Genome-wide association study of peripheral artery disease in the Million Veteran Program.1 passage
• Genome-wide cell-free DNA mutational integration enables ultra-sensitive cancer monitoring.1 passage
• Genome-wide germline correlates of the epigenetic landscape of prostate cancer.1 passage
• Genome-wide identification of microRNAs regulating cholesterol and triglyceride homeostasis.1 passage
• Genomic and epidemiological evidence of bacterial transmission from probiotic capsule to blood in ICU patients.1 passage
• Genomic and transcriptomic profiling expands precision cancer medicine: the WINTHER trial.1 passage
• Genomic copy number predicts esophageal cancer years before transformation.1 passage
• Genomic correlates of response to immune checkpoint blockade.1 passage
• Genomic diversity in autopsy samples reveals within-host dissemination of HIV-associated Mycobacterium tuberculosis.1 passage
• Genomic landscape of carcinogen-induced and genetically induced mouse skin squamous cell carcinoma.1 passage
• Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression.1 passage
• Geospatial immune variability illuminates differential evolution of lung adenocarcinoma.1 passage
• Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing.1 passage
• Global maps of travel time to healthcare facilities.1 passage
• Glomerular filtration rate by differing measures, albuminuria and prediction of cardiovascular disease, mortality and end-stage kidney disease.1 passage
• Glucocorticoid hormone-induced chromatin remodeling enhances human hematopoietic stem cell homing and engraftment.1 passage
• Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy.1 passage
• Guidelines for clinical trial protocols for interventions involving artificial intelligence: the SPIRIT-AI extension.1 passage
• Gut microbiome alteration in MORDOR I: a community-randomized trial of mass azithromycin distribution.1 passage
• Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention.1 passage
• Gut microbiota and intestinal FXR mediate the clinical benefits of metformin.1 passage
• Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade.1 passage
• Gut microbiota-bile acid-interleukin-22 axis orchestrates polycystic ovary syndrome.1 passage
• H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers.1 passage
• HAUSP deubiquitinates and stabilizes N-Myc in neuroblastoma.1 passage
• HIV is associated with an increased risk of age-related clonal hematopoiesis among older adults.1 passage
• HIV persistence in tissue macrophages of humanized myeloid-only mice during antiretroviral therapy.1 passage
• HIV-1 infections with multiple founders are associated with higher viral loads than infections with single founders.1 passage
• HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures.1 passage
• Hair follicle-derived IL-7 and IL-15 mediate skin-resident memory T cell homeostasis and lymphoma.1 passage
• Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons.1 passage
• Health systems resilience in managing the COVID-19 pandemic: lessons from 28 countries.1 passage
• Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice.1 passage
• Healthy infants harbor intestinal bacteria that protect against food allergy.1 passage
• Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection.1 passage
• Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes.1 passage
• Hepatitis-C-virus-induced microRNAs dampen interferon-mediated antiviral signaling.1 passage
• Heterogeneity of autoimmune diseases: pathophysiologic insights from genetics and implications for new therapies.1 passage
• High prevalence of Streptococcus pyogenes Cas9-reactive T cells within the adult human population.1 passage
• High systemic and tumor-associated IL-8 correlates with reduced clinical benefit of PD-L1 blockade.1 passage
• High-dimensional single-cell analysis predicts response to anti-PD-1 immunotherapy.1 passage
• High-frequency neuromodulation improves obsessive-compulsive behavior.1 passage
• High-intensity sequencing reveals the sources of plasma circulating cell-free DNA variants.1 passage
• High-performance medicine: the convergence of human and artificial intelligence.1 passage
• High-resolution mycobiota analysis reveals dynamic intestinal translocation preceding invasive candidiasis.1 passage
• High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma.1 passage
• High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response.1 passage
• Highly efficient therapeutic gene editing of human hematopoietic stem cells.1 passage
• Homeostatic regulation of T cell trafficking by a B cell-derived peptide is impaired in autoimmune and chronic inflammatory disease.1 passage
• Homozygous BCMA gene deletion in response to anti-BCMA CAR T cells in a patient with multiple myeloma.1 passage
• Host DNA released by NETosis promotes rhinovirus-induced type-2 allergic asthma exacerbation.1 passage
• How medical AI devices are evaluated: limitations and recommendations from an analysis of FDA approvals.1 passage
• Human 'brite/beige' adipocytes develop from capillary networks, and their implantation improves metabolic homeostasis in mice.1 passage
• Human 3D cellular model of hypoxic brain injury of prematurity.1 passage
• Human SNORA31 variations impair cortical neuron-intrinsic immunity to HSV-1 and underlie herpes simplex encephalitis.1 passage
• Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease.1 passage
• Human antibody repertoire after VSV-Ebola vaccination identifies novel targets and virus-neutralizing IgM antibodies.1 passage
• Human induced pluripotent stem cell-derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity.1 passage
• Human postprandial responses to food and potential for precision nutrition.1 passage
• Human primary liver cancer-derived organoid cultures for disease modeling and drug screening.1 passage
• Human-computer collaboration for skin cancer recognition.1 passage
• Human-monoclonal-antibody therapy protects nonhuman primates against advanced Lassa fever.1 passage
• Humoral and circulating follicular helper T cell responses in recovered patients with COVID-19.1 passage
• Humoral signatures of protective and pathological SARS-CoV-2 infection in children.1 passage
• Hyaluronan and TLR4 promote surfactant-protein-C-positive alveolar progenitor cell renewal and prevent severe pulmonary fibrosis in mice.1 passage
• IAP antagonists induce anti-tumor immunity in multiple myeloma.1 passage
• IFN-γ-independent immune markers of Mycobacterium tuberculosis exposure.1 passage
• IL-1-driven stromal-neutrophil interactions define a subset of patients with inflammatory bowel disease that does not respond to therapies.1 passage
• IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases.1 passage
• IL1R1 is required for celastrol's leptin-sensitization and antiobesity effects.1 passage
• ISDoT: in situ decellularization of tissues for high-resolution imaging and proteomic analysis of native extracellular matrix.1 passage
• Identification of a major epitope by anti-interferon-γ autoantibodies in patients with mycobacterial disease.1 passage
• Identification of a new orthonairovirus associated with human febrile illness in China.1 passage
• Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia.1 passage
• Identification of preexisting adaptive immunity to Cas9 proteins in humans.1 passage
• Identification of rare-disease genes using blood transcriptome sequencing and large control cohorts.1 passage
• Identification of resistance pathways and therapeutic targets in relapsed multiple myeloma patients through single-cell sequencing.1 passage
• Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen.1 passage
• Identifying facial phenotypes of genetic disorders using deep learning.1 passage
• If the world fails to protect the economy, COVID-19 will damage health not just now but also in the future.1 passage
• IgG-cleaving endopeptidase enables in vivo gene therapy in the presence of anti-AAV neutralizing antibodies.1 passage
• Immune and genomic correlates of response to anti-PD-1 immunotherapy in glioblastoma.1 passage
• Immune complement and coagulation dysfunction in adverse outcomes of SARS-CoV-2 infection.1 passage
• Immune determinants of COVID-19 disease presentation and severity.1 passage
• Immune induction strategies in metastatic triple-negative breast cancer to enhance the sensitivity to PD-1 blockade: the TONIC trial.1 passage
• Immune profiling of human tumors identifies CD73 as a combinatorial target in glioblastoma.1 passage
• Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer.1 passage
• Immune responses against SARS-CoV-2 variants after heterologous and homologous ChAdOx1 nCoV-19/BNT162b2 vaccination.1 passage
• Immune responses to two and three doses of the BNT162b2 mRNA vaccine in adults with solid tumors.1 passage
• Immune signature drives leukemia escape and relapse after hematopoietic cell transplantation.1 passage
• Immunogenic neoantigens derived from gene fusions stimulate T cell responses.1 passage
• Immunogenicity and reactogenicity of heterologous ChAdOx1 nCoV-19/mRNA vaccination.1 passage
• Immunogenicity and safety of the CoronaVac inactivated vaccine in patients with autoimmune rheumatic diseases: a phase 4 trial.1 passage
• Immunomodulatory drugs disrupt the cereblon-CD147-MCT1 axis to exert antitumor activity and teratogenicity.1 passage
• Impact of pre-adapted HIV transmission.1 passage
• Impact of vaccination on new SARS-CoV-2 infections in the United Kingdom.1 passage
• Impaired meningeal lymphatic drainage in patients with idiopathic Parkinson's disease.1 passage
• Implant-derived magnesium induces local neuronal production of CGRP to improve bone-fracture healing in rats.1 passage
• Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes.1 passage
• Implications of human genetic variation in CRISPR-based therapeutic genome editing.1 passage
• Improving prevention strategies for cardiometabolic disease.1 passage
• In utero CRISPR-mediated therapeutic editing of metabolic genes.1 passage
• In vitro fertilization does not increase the incidence of de novo copy number alterations in fetal and placental lineages.1 passage
• In-depth determination and analysis of the human paired heavy- and light-chain antibody repertoire.1 passage
• Inactivating hepatic follistatin alleviates hyperglycemia.1 passage
• Increased circulation time of Plasmodium falciparum underlies persistent asymptomatic infection in the dry season.1 passage
• Individual and community-level risk for COVID-19 mortality in the United States.1 passage
• Individualized therapy trials: navigating patient care, research goals and ethics.1 passage
• Inducible depletion of satellite cells in adult, sedentary mice impairs muscle regenerative capacity without affecting sarcopenia.1 passage
• Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell.1 passage
• Infant diet and maternal gestational weight gain predict early metabolic maturation of gut microbiomes.1 passage
• Infection of bat and human intestinal organoids by SARS-CoV-2.1 passage
• Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt.1 passage
• Inflammasomes: mechanism of action, role in disease, and therapeutics.1 passage
• Inflammatory signaling in human tuberculosis granulomas is spatially organized.1 passage
• Influence of nutrient-derived metabolites on lymphocyte immunity.1 passage
• Influenza immunization elicits antibodies specific for an egg-adapted vaccine strain.1 passage
• Inherited PD-1 deficiency underlies tuberculosis and autoimmunity in a child.1 passage
• Inhibition of a G9a/DNMT network triggers immune-mediated bladder cancer regression.1 passage
• Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models.1 passage
• Inhibition of amyloid-β plaque formation by α-synuclein.1 passage
• Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer.1 passage
• Inhibition of hypoxia-inducible factor-2α in renal cell carcinoma with belzutifan: a phase 1 trial and biomarker analysis.1 passage
• Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade.1 passage
• Inhibition of phosphodiesterase-4D in adults with fragile X syndrome: a randomized, placebo-controlled, phase 2 clinical trial.1 passage
• Inhibition of the glucose transporter SGLT2 with dapagliflozin in pancreatic alpha cells triggers glucagon secretion.1 passage
• Initial report of decreased SARS-CoV-2 viral load after inoculation with the BNT162b2 vaccine.1 passage
• Initial results from a first-in-human gene therapy trial on X-linked retinitis pigmentosa caused by mutations in RPGR.1 passage
• Innate lymphoid cells in the initiation, regulation and resolution of inflammation.1 passage
• Insulin action and resistance in obesity and type 2 diabetes.1 passage
• Insulin dose optimization using an automated artificial intelligence-based decision support system in youths with type 1 diabetes.1 passage
• Insulin is expressed by enteroendocrine cells during human fetal development.1 passage
• Integrated genomic, epidemiologic investigation of Candida auris skin colonization in a skilled nursing facility.1 passage
• Integrated single-cell analysis of multicellular immune dynamics during hyperacute HIV-1 infection.1 passage
• Integration of epidemiologic, pharmacologic, genetic and gut microbiome data in a drug-metabolite atlas.1 passage
• Integration of genomic sequencing into the response to the Ebola virus outbreak in Nord Kivu, Democratic Republic of the Congo.1 passage
• Integrative microbiomics in bronchiectasis exacerbations.1 passage
• Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma.1 passage
• Inter-individual variability and genetic influences on cytokine responses to bacteria and fungi.1 passage
• Interictal epileptiform discharges induce hippocampal-cortical coupling in temporal lobe epilepsy.1 passage
• Interleukin-22-mediated host glycosylation prevents Clostridioides difficile infection by modulating the metabolic activity of the gut microbiota.1 passage
• Interleukin-33-induced expression of PIBF1 by decidual B cells protects against preterm labor.1 passage
• International AIDS Society global scientific strategy: towards an HIV cure 2016.1 passage
• Interplay of somatic alterations and immune infiltration modulates response to PD-1 blockade in advanced clear cell renal cell carcinoma.1 passage
• Intrabone hematopoietic stem cell gene therapy for adult and pediatric patients affected by transfusion-dependent ß-thalassemia.1 passage
• Intracellular MLCK1 diversion reverses barrier loss to restore mucosal homeostasis.1 passage
• Intratumoral heterogeneity in cancer progression and response to immunotherapy.1 passage
• Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation.1 passage
• Investigation of the role of typhoid toxin in acute typhoid fever in a human challenge model.1 passage
• Irf5 deficiency in macrophages promotes beneficial adipose tissue expansion and insulin sensitivity during obesity.1 passage
• Is autoimmunity the Achilles' heel of cancer immunotherapy?1 passage
• Is earlier better for melanoma checkpoint blockade?1 passage
• Isocitrate dehydrogenase 1 and 2 mutations induce BCL-2 dependence in acute myeloid leukemia.1 passage
• JNK1 negatively controls antifungal innate immunity by suppressing CD23 expression.1 passage
• Joint international consensus statement for ending stigma of obesity.1 passage
• KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis.1 passage
• Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis.1 passage
• Keeping governments accountable: the COVID-19 Assessment Scorecard (COVID-SCORE).1 passage
• Killer lymphocytes use granulysin, perforin and granzymes to kill intracellular parasites.1 passage
• Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis.1 passage
• LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption.1 passage
• Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation.1 passage
• Late-stage tumors induce anemia and immunosuppressive extramedullary erythroid progenitor cells.1 passage
• Learning from clinical trials of neoadjuvant checkpoint blockade.1 passage
• Lentiviral gene therapy for X-linked chronic granulomatous disease.1 passage
• Life expectancy and mortality in 363 cities of Latin America.1 passage
• Limited evolution of the actionable metastatic cancer genome under therapeutic pressure.1 passage
• Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers.1 passage
• Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination.1 passage
• Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment.1 passage
• Locoregional delivery of CAR T cells to the cerebrospinal fluid for treatment of metastatic medulloblastoma and ependymoma.1 passage
• Locoregional infusion of HER2-specific CAR T cells in children and young adults with recurrent or refractory CNS tumors: an interim analysis.1 passage
• Locoregionally administered B7-H3-targeted CAR T cells for treatment of atypical teratoid/rhabdoid tumors.1 passage
• Long COVID in a prospective cohort of home-isolated patients.1 passage
• Long noncoding RNA EGFR-AS1 mediates epidermal growth factor receptor addiction and modulates treatment response in squamous cell carcinoma.1 passage
• Long-term ecological assessment of intracranial electrophysiology synchronized to behavioral markers in obsessive-compulsive disorder.1 passage
• Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mice.1 passage
• Longitudinal personal DNA methylome dynamics in a human with a chronic condition.1 passage
• Looking beyond COVID-19 vaccine phase 3 trials.1 passage
• Loss of BAP1 function leads to EZH2-dependent transformation.1 passage
• Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes.1 passage
• Loss of cohesin complex components STAG2 or STAG3 confers resistance to BRAF inhibition in melanoma.1 passage
• Loss of the co-repressor GPS2 sensitizes macrophage activation upon metabolic stress induced by obesity and type 2 diabetes.1 passage
• Loss of the histone methyltransferase EZH2 induces resistance to multiple drugs in acute myeloid leukemia.1 passage
• Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling.1 passage
• Loss-of-function mutations in MRAP2 are pathogenic in hyperphagic obesity with hyperglycemia and hypertension.1 passage
• Loss-of-function mutations in the melanocortin 4 receptor in a UK birth cohort.1 passage
• Low and variable tumor reactivity of the intratumoral TCR repertoire in human cancers.1 passage
• Low-dose interleukin-2 treatment selectively modulates CD4(+) T cell subsets in patients with systemic lupus erythematosus.1 passage
• Low-frequency cortical activity is a neuromodulatory target that tracks recovery after stroke.1 passage
• MARCH8 inhibits HIV-1 infection by reducing virion incorporation of envelope glycoproteins.1 passage
• MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency.1 passage
• MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study.1 passage
• Macrophage extracellular trap formation promoted by platelet activation is a key mediator of rhabdomyolysis-induced acute kidney injury.1 passage
• Magnitude, demographics and dynamics of the effect of the first wave of the COVID-19 pandemic on all-cause mortality in 21 industrialized countries.1 passage
• Major histocompatibility complex class I molecules protect motor neurons from astrocyte-induced toxicity in amyotrophic lateral sclerosis.1 passage
• Malaria is a cause of iron deficiency in African children.1 passage
• Mapping exclusive breastfeeding in Africa between 2000 and 2017.1 passage
• Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017.1 passage
• Marginal zone B cells control the response of follicular helper T cells to a high-cholesterol diet.1 passage
• Maternal IgA protects against the development of necrotizing enterocolitis in preterm infants.1 passage
• Maternal cannabis use in pregnancy and child neurodevelopmental outcomes.1 passage
• Maturation of the gut microbiome during the first year of life contributes to the protective farm effect on childhood asthma.1 passage
• Maturation of the infant microbiome community structure and function across multiple body sites and in relation to mode of delivery.1 passage
• Mechanisms and clinical activity of an EGFR and HER2 exon 20-selective kinase inhibitor in non-small cell lung cancer.1 passage
• Mechanisms of NAFLD development and therapeutic strategies.1 passage
• Meeting brain-computer interface user performance expectations using a deep neural network decoding framework.1 passage
• Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer.1 passage
• Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.1 passage
• Meta-omics analysis of elite athletes identifies a performance-enhancing microbe that functions via lactate metabolism.1 passage
• Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α.1 passage
• Metabolic perturbations and cellular stress underpin susceptibility to symptomatic live-attenuated yellow fever infection.1 passage
• Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells.1 passage
• Metagenomic analysis of colorectal cancer datasets identifies cross-cohort microbial diagnostic signatures and a link with choline degradation.1 passage
• Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer.1 passage
• Metastatic cancers promote cachexia through ZIP14 upregulation in skeletal muscle.1 passage
• Metformin activates a duodenal Ampk-dependent pathway to lower hepatic glucose production in rats.1 passage
• Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug.1 passage
• Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase.1 passage
• Metformin reverses established lung fibrosis in a bleomycin model.1 passage
• Methionine is a metabolic dependency of tumor-initiating cells.1 passage
• MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels.1 passage
• Microbial network disturbances in relapsing refractory Crohn's disease.1 passage
• Microbiome and health implications for ethnic minorities after enforced lifestyle changes.1 passage
• Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals.1 passage
• Microenvironment-dependent growth of preneoplastic and malignant plasma cells in humanized mice.1 passage
• Microenvironmental control of breast cancer subtype elicited through paracrine platelet-derived growth factor-CC signaling.1 passage
• Microglia emerge as central players in brain disease.1 passage
• Microglial activation and tau propagate jointly across Braak stages.1 passage
• Midkine rewires the melanoma microenvironment toward a tolerogenic and immune-resistant state.1 passage
• Minimal PU.1 reduction induces a preleukemic state and promotes development of acute myeloid leukemia.1 passage
• MitoTALEN reduces mutant mtDNA load and restores tRNA1 passage
• Mitochondrial DNA variants modulate N-formylmethionine, proteostasis and risk of late-onset human diseases.1 passage
• Mitochondrial iron chelation ameliorates cigarette smoke-induced bronchitis and emphysema in mice.1 passage
• Modeling COVID-19 scenarios for the United States.1 passage
• Modeling Smith-Lemli-Opitz syndrome with induced pluripotent stem cells reveals a causal role for Wnt/β-catenin defects in neuronal cholesterol synthesis phenotypes.1 passage
• Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids.1 passage
• Modeling human adaptive immune responses with tonsil organoids.1 passage
• Modeling psychiatric disorders for developing effective treatments.1 passage
• Modeling shield immunity to reduce COVID-19 epidemic spread.1 passage
• Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent.1 passage
• Modeling vaccination rollouts, SARS-CoV-2 variants and the requirement for non-pharmaceutical interventions in Italy.1 passage
• Modelling the COVID-19 epidemic and implementation of population-wide interventions in Italy.1 passage
• Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins.1 passage
• Molecular analysis of circulating tumor cells identifies distinct copy-number profiles in patients with chemosensitive and chemorefractory small-cell lung cancer.1 passage
• Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes.1 passage
• Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women.1 passage
• Molecular profiling of cancer patients enables personalized combination therapy: the I-PREDICT study.1 passage
• Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes.1 passage
• Molecular-level analysis of the serum antibody repertoire in young adults before and after seasonal influenza vaccination.1 passage
• Monocyte-derived IL-1 and IL-6 are differentially required for cytokine-release syndrome and neurotoxicity due to CAR T cells.1 passage
• Multimodel preclinical platform predicts clinical response of melanoma to immunotherapy.1 passage
• Multiplexed single-cell morphometry for hematopathology diagnostics.1 passage
• Multiscale reverse engineering of the human ocular surface.1 passage
• Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase.1 passage
• Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.1 passage
• Mutations and variants of ONECUT1 in diabetes.1 passage
• Mutations in ACTRT1 and its enhancer RNA elements lead to aberrant activation of Hedgehog signaling in inherited and sporadic basal cell carcinomas.1 passage
• Mutations in G protein β subunits promote transformation and kinase inhibitor resistance.1 passage
• Mutations in the SWI/SNF complex induce a targetable dependence on oxidative phosphorylation in lung cancer.1 passage
• Myelodysplastic syndrome progression to acute myeloid leukemia at the stem cell level.1 passage
• Myeloid cell contributions to cardiovascular health and disease.1 passage
• Myeloid-derived growth factor (C19orf10) mediates cardiac repair following myocardial infarction.1 passage
• Myocardial infarction accelerates breast cancer via innate immune reprogramming.1 passage
• Myostatin is a direct regulator of osteoclast differentiation and its inhibition reduces inflammatory joint destruction in mice.1 passage
• NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages.1 passage
• NY-ESO-1-specific TCR-engineered T cells mediate sustained antigen-specific antitumor effects in myeloma.1 passage
• Natural and therapy-induced immunosurveillance in breast cancer.1 passage
• Near real-time intraoperative brain tumor diagnosis using stimulated Raman histology and deep neural networks.1 passage
• Negative feedback-defective PRPS1 mutants drive thiopurine resistance in relapsed childhood ALL.1 passage
• Neoadjuvant PD-L1 plus CTLA-4 blockade in patients with cisplatin-ineligible operable high-risk urothelial carcinoma.1 passage
• Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma.1 passage
• Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma.1 passage
• Neoadjuvant immunotherapy leads to pathological responses in MMR-proficient and MMR-deficient early-stage colon cancers.1 passage
• Neoadjuvant nivolumab modifies the tumor immune microenvironment in resectable glioblastoma.1 passage
• Neoadjuvant nivolumab or nivolumab plus ipilimumab in operable non-small cell lung cancer: the phase 2 randomized NEOSTAR trial.1 passage
• Neoadjuvant talimogene laherparepvec plus surgery versus surgery alone for resectable stage IIIB-IVM1a melanoma: a randomized, open-label, phase 2 trial.1 passage
• Neoadjuvant versus adjuvant ipilimumab plus nivolumab in macroscopic stage III melanoma.1 passage
• Neonatal gut microbiota associates with childhood multisensitized atopy and T cell differentiation.1 passage
• Neurocognitive and hypokinetic movement disorder with features of parkinsonism after BCMA-targeting CAR-T cell therapy.1 passage
• Neurogenetic contributions to amyloid beta and tau spreading in the human cortex.1 passage
• Neurological complications after first dose of COVID-19 vaccines and SARS-CoV-2 infection.1 passage
• Neuromodulation of lumbosacral spinal networks enables independent stepping after complete paraplegia.1 passage
• Neuronal defects in a human cellular model of 22q11.2 deletion syndrome.1 passage
• Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K and N501Y variants by BNT162b2 vaccine-elicited sera.1 passage
• Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection.1 passage
• Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease.1 passage
• Neutrophils promote Alzheimer's disease-like pathology and cognitive decline via LFA-1 integrin.1 passage
• Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization.1 passage
• Nitric oxide mediates aortic disease in mice deficient in the metalloprotease Adamts1 and in a mouse model of Marfan syndrome.1 passage
• No causal effect of school closures in Japan on the spread of COVID-19 in spring 2020.1 passage
• Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure.1 passage
• Non-immunogenic utrophin gene therapy for the treatment of muscular dystrophy animal models.1 passage
• Non-invasive prenatal sequencing for multiple Mendelian monogenic disorders using circulating cell-free fetal DNA.1 passage
• Noncanonical hedgehog pathway activation through SRF-MKL1 promotes drug resistance in basal cell carcinomas.1 passage
• Notch controls the survival of memory CD4+ T cells by regulating glucose uptake.1 passage
• Novel assay reveals a large, inducible, replication-competent HIV-1 reservoir in resting CD41 passage
• Novel correlates of protection against pandemic H1N1 influenza A virus infection.1 passage
• ONECUT2 is a targetable master regulator of lethal prostate cancer that suppresses the androgen axis.1 passage
• Obesity and hyperinsulinemia drive adipocytes to activate a cell cycle program and senesce.1 passage
• Omega-3 fatty acid epoxides are autocrine mediators that control the magnitude of IgE-mediated mast cell activation.1 passage
• On the responsible use of digital data to tackle the COVID-19 pandemic.1 passage
• Oncogenic hijacking of the stress response machinery in T cell acute lymphoblastic leukemia.1 passage
• Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease.1 passage
• Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors.1 passage
• Opposing immune and genetic mechanisms shape oncogenic programs in synovial sarcoma.1 passage
• Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis.1 passage
• PCSK6-mediated corin activation is essential for normal blood pressure.1 passage
• PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer's disease.1 passage
• PD-1(+) and follicular helper T cells are responsible for persistent HIV-1 transcription in treated aviremic individuals.1 passage
• PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC expression.1 passage
• PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer.1 passage
• PM20D1 is a quantitative trait locus associated with Alzheimer's disease.1 passage
• PPAR-δ is repressed in Huntington's disease, is required for normal neuronal function and can be targeted therapeutically.1 passage
• PPIL4 is essential for brain angiogenesis and implicated in intracranial aneurysms in humans.1 passage
• PTEN opposes negative selection and enables oncogenic transformation of pre-B cells.1 passage
• Pan-cancer analysis of the extent and consequences of intratumor heterogeneity.1 passage
• Pan-viral serology implicates enteroviruses in acute flaccid myelitis.1 passage
• Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade.1 passage
• Parkinson's disease-associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes.1 passage
• Partial recovery of visual function in a blind patient after optogenetic therapy.1 passage
• Partial restoration of the microbiota of cesarean-born infants via vaginal microbial transfer.1 passage
• Pathological response and survival with neoadjuvant therapy in melanoma: a pooled analysis from the International Neoadjuvant Melanoma Consortium (INMC).1 passage
• Pathophysiology-based subphenotyping of individuals at elevated risk for type 2 diabetes.1 passage
• Patient-derived induced pluripotent stem cells in cancer research and precision oncology.1 passage
• Pericyte degeneration causes white matter dysfunction in the mouse central nervous system.1 passage
• Peripheral CD81 passage
• Peripheral immunophenotypes in children with multisystem inflammatory syndrome associated with SARS-CoV-2 infection.1 passage
• Persisting positron emission tomography lesion activity and Mycobacterium tuberculosis mRNA after tuberculosis cure.1 passage
• Personal aging markers and ageotypes revealed by deep longitudinal profiling.1 passage
• Personal clinical history predicts antibiotic resistance of urinary tract infections.1 passage
• Personal neoantigen vaccines induce persistent memory T cell responses and epitope spreading in patients with melanoma.1 passage
• Personalized lab test models to quantify disease potentials in healthy individuals.1 passage
• Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models.1 passage
• Pharmacological targeting of actin-dependent dynamin oligomerization ameliorates chronic kidney disease in diverse animal models.1 passage
• Phase 1 randomized trial of a plant-derived virus-like particle vaccine for COVID-19.1 passage
• Phase 1/2 trial of SARS-CoV-2 vaccine ChAdOx1 nCoV-19 with a booster dose induces multifunctional antibody responses.1 passage
• Phenome-based approach identifies RIC1-linked Mendelian syndrome through zebrafish models, biobank associations and clinical studies.1 passage
• Phenotype molding of stromal cells in the lung tumor microenvironment.1 passage
• Phenotypic signatures in clinical data enable systematic identification of patients for genetic testing.1 passage
• Pirfenidone in heart failure with preserved ejection fraction: a randomized phase 2 trial.1 passage
• Plasma P-tau181 in Alzheimer's disease: relationship to other biomarkers, differential diagnosis, neuropathology and longitudinal progression to Alzheimer's dementia.1 passage
• Plasma metabolites to profile pathways in noncommunicable disease multimorbidity.1 passage
• Plasma protein patterns as comprehensive indicators of health.1 passage
• Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer.1 passage
• Poly(GR) impairs protein translation and stress granule dynamics in C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis.1 passage
• Polyclonal and convergent antibody response to Ebola virus vaccine rVSV-ZEBOV.1 passage
• Polygenic and clinical risk scores and their impact on age at onset and prediction of cardiometabolic diseases and common cancers.1 passage
• Polygenic architecture informs potential vulnerability to drug-induced liver injury.1 passage
• Population genetic screening efficiently identifies carriers of autosomal dominant diseases.1 passage
• Population-based surveys of antibodies against SARS-CoV-2 in Southern Brazil.1 passage
• Population-wide diversity and stability of serum antibody epitope repertoires against human microbiota.1 passage
• Positively selected enhancer elements endow osteosarcoma cells with metastatic competence.1 passage
• Post-acute COVID-19 syndrome.1 passage
• Potent Zika and dengue cross-neutralizing antibodies induced by Zika vaccination in a dengue-experienced donor.1 passage
• Potent antibody-mediated neutralization limits bacteriophage treatment of a pulmonary Mycobacterium abscessus infection.1 passage
• Potent antitumor efficacy of anti-GD2 CAR T cells in H3-K27M1 passage
• Powered hip exoskeleton improves walking economy in individuals with above-knee amputation.1 passage
• PrEP rollout in Africa: status and opportunity.1 passage
• Pre-existing immunity to influenza virus hemagglutinin stalk might drive selection for antibody-escape mutant viruses in a human challenge model.1 passage
• Precision epidemiology for infectious disease control.1 passage
• Precision identification of diverse bloodstream pathogens in the gut microbiome.1 passage
• Precision medicine treatment in acute myeloid leukemia using prospective genomic profiling: feasibility and preliminary efficacy of the Beat AML Master Trial.1 passage
• Preconditioning allows engraftment of mouse and human embryonic lung cells, enabling lung repair in mice.1 passage
• Predicting conversion to wet age-related macular degeneration using deep learning.1 passage
• Predicting the early risk of chronic kidney disease in patients with diabetes using real-world data.1 passage
• Prediction of future Alzheimer's disease dementia using plasma phospho-tau combined with other accessible measures.1 passage
• Prediction of gestational diabetes based on nationwide electronic health records.1 passage
• Prediction of mortality from 12-lead electrocardiogram voltage data using a deep neural network.1 passage
• Predictors of COVID-19 epidemics in countries of the World Health Organization African Region.1 passage
• Prenatal androgen exposure and transgenerational susceptibility to polycystic ovary syndrome.1 passage
• Preoperative ipilimumab plus nivolumab in locoregionally advanced urothelial cancer: the NABUCCO trial.1 passage
• Preventing dysbiosis of the neonatal mouse intestinal microbiome protects against late-onset sepsis.1 passage
• Principles of and strategies for germline gene therapy.1 passage
• Prisons as ecological drivers of fitness-compensated multidrug-resistant Mycobacterium tuberculosis.1 passage
• Privacy in the age of medical big data.1 passage
• Production, safety and efficacy of iPSC-derived mesenchymal stromal cells in acute steroid-resistant graft versus host disease: a phase I, multicenter, open-label, dose-escalation study.1 passage
• Prognostic value of polygenic risk scores for adults with psychosis.1 passage
• Programmable bacteria induce durable tumor regression and systemic antitumor immunity.1 passage
• Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients.1 passage
• Prospective virome analyses in young children at increased genetic risk for type 1 diabetes.1 passage
• Prospects for gene-engineered T cell immunotherapy for solid cancers.1 passage
• Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4.1 passage
• Protection against malaria at 1 year and immune correlates following PfSPZ vaccination.1 passage
• Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers.1 passage
• Proteostasis and aging.1 passage
• Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse.1 passage
• Putting decisions under the microscope.1 passage
• Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction.1 passage
• RAF inhibitor PLX8394 selectively disrupts BRAF dimers and RAS-independent BRAF-mutant-driven signaling.1 passage
• RANK ligand as a potential target for breast cancer prevention in BRCA1-mutation carriers.1 passage
• RAS-MAPK dependence underlies a rational polytherapy strategy in EML4-ALK-positive lung cancer.1 passage
• RIFINs are adhesins implicated in severe Plasmodium falciparum malaria.1 passage
• RNA interference-induced hepatotoxicity results from loss of the first synthesized isoform of microRNA-122 in mice.1 passage
• ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer.1 passage
• Racioethnic diversity in the dynamics of the vaginal microbiome during pregnancy.1 passage
• Radiotherapy induces responses of lung cancer to CTLA-4 blockade.1 passage
• Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection.1 passage
• Rapid SARS-CoV-2 whole-genome sequencing and analysis for informed public health decision-making in the Netherlands.1 passage
• Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein.1 passage
• Rapid mass spectrometric conversion of tissue biopsy samples into permanent quantitative digital proteome maps.1 passage
• Rapid pathogen detection by metagenomic next-generation sequencing of infected body fluids.1 passage
• Rational design of anti-GITR-based combination immunotherapy.1 passage
• Re-evaluating the link between neuropsychiatric disorders and dysregulated adult neurogenesis.1 passage
• Real-time alerting system for COVID-19 and other stress events using wearable data.1 passage
• Real-time tracking of self-reported symptoms to predict potential COVID-19.1 passage
• Reciprocal cellular cross-talk within the tumor microenvironment promotes oncolytic virus activity.1 passage
• Recommendations for measuring HIV reservoir size in cure-directed clinical trials.1 passage
• Reconstruction of the human blood-brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes.1 passage
• Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids.1 passage
• Recurrent ECSIT mutation encoding V140A triggers hyperinflammation and promotes hemophagocytic syndrome in extranodal NK/T cell lymphoma.1 passage
• Recurrent MET fusion genes represent a drug target in pediatric glioblastoma.1 passage
• Reduction in life expectancy in Brazil after COVID-19.1 passage
• Refining strategies to translate genome editing to the clinic.1 passage
• Regenerative lineages and immune-mediated pruning in lung cancer metastasis.1 passage
• Regional variation limits applications of healthy gut microbiome reference ranges and disease models.1 passage
• Regulatory T cells impede acute and long-term immunity to blood-stage malaria through CTLA-4.1 passage
• Regulatory, safety, and privacy concerns of home monitoring technologies during COVID-19.1 passage
• Renal compartment-specific genetic variation analyses identify new pathways in chronic kidney disease.1 passage
• Reply to 'A critical analysis of neurodevelopmental and neurosensory outcomes after 2 years for children with in utero Zika virus exposure'.1 passage
• Reporting guidelines for clinical trial reports for interventions involving artificial intelligence: the CONSORT-AI extension.1 passage
• Reporting guidelines for human microbiome research: the STORMS checklist.1 passage
• Research priorities for an HIV cure: International AIDS Society Global Scientific Strategy 2021.1 passage
• Resistance of SARS-CoV-2 variants to neutralization by monoclonal and serum-derived polyclonal antibodies.1 passage
• Resistance to TRK inhibition mediated by convergent MAPK pathway activation.1 passage
• Resistance to autosomal dominant Alzheimer's disease in an APOE3 Christchurch homozygote: a case report.1 passage
• Resolution of inflammation by interleukin-9-producing type 2 innate lymphoid cells.1 passage
• Respiratory virus shedding in exhaled breath and efficacy of face masks.1 passage
• Responsible use of polygenic risk scores in the clinic: potential benefits, risks and gaps.1 passage
• Resting-state connectivity biomarkers define neurophysiological subtypes of depression.1 passage
• Restorative effects of human neural stem cell grafts on the primate spinal cord.1 passage
• Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network.1 passage
• Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1.1 passage
• Retrieval of vector integration sites from cell-free DNA.1 passage
• Retrotransposon insertions in the clonal evolution of pancreatic ductal adenocarcinoma.1 passage
• Revealing COVID-19 transmission in Australia by SARS-CoV-2 genome sequencing and agent-based modeling.1 passage
• Reversing excitatory GABAAR signaling restores synaptic plasticity and memory in a mouse model of Down syndrome.1 passage
• Right data for right patient-a precisionFDA NCI-CPTAC Multi-omics Mislabeling Challenge.1 passage
• Robust breast cancer detection in mammography and digital breast tomosynthesis using an annotation-efficient deep learning approach.1 passage
• Robust prediction of response to immune checkpoint blockade therapy in metastatic melanoma.1 passage
• Route of immunization defines multiple mechanisms of vaccine-mediated protection against SIV.1 passage
• Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9.1 passage
• SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia.1 passage
• SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma.1 passage
• SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes.1 passage
• SARS-CoV-2 infection of the oral cavity and saliva.1 passage
• SHP2 inhibition restores sensitivity in ALK-rearranged non-small-cell lung cancer resistant to ALK inhibitors.1 passage
• SHP2 is required for growth of KRAS-mutant non-small-cell lung cancer in vivo.1 passage
• SNP-mediated disruption of CTCF binding at the IFITM3 promoter is associated with risk of severe influenza in humans.1 passage
• STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis.1 passage
• SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2.1 passage
• Safety and antiviral activity of combination HIV-1 broadly neutralizing antibodies in viremic individuals.1 passage
• Safety and efficacy of anti-tau monoclonal antibody gosuranemab in progressive supranuclear palsy: a phase 2, randomized, placebo-controlled trial.1 passage
• Safety and efficacy of avapritinib in advanced systemic mastocytosis: the phase 1 EXPLORER trial.1 passage
• Safety and feasibility of CRISPR-edited T cells in patients with refractory non-small-cell lung cancer.1 passage
• Safety and feasibility of anti-CD19 CAR T cells with fully human binding domains in patients with B-cell lymphoma.1 passage
• Safety and immunogenicity of Ad26 and MVA vaccines in acutely treated HIV and effect on viral rebound after antiretroviral therapy interruption.1 passage
• Safety and immunogenicity of SARS-CoV-2 variant mRNA vaccine boosters in healthy adults: an interim analysis.1 passage
• Safety and immunogenicity of the SARS-CoV-2 BNT162b1 mRNA vaccine in younger and older Chinese adults: a randomized, placebo-controlled, double-blind phase 1 study.1 passage
• Safety and pharmacokinetics of islatravir subdermal implant for HIV-1 pre-exposure prophylaxis: a randomized, placebo-controlled phase 1 trial.1 passage
• Safety profile of autologous macrophage therapy for liver cirrhosis.1 passage
• Safety, immunogenicity and efficacy of PfSPZ Vaccine against malaria in infants in western Kenya: a double-blind, randomized, placebo-controlled phase 2 trial.1 passage
• Safety, pharmacokinetics and antiviral activity of PGT121, a broadly neutralizing monoclonal antibody against HIV-1: a randomized, placebo-controlled, phase 1 clinical trial.1 passage
• Safety, tolerability and antiviral activity of the antisense oligonucleotide bepirovirsen in patients with chronic hepatitis B: a phase 2 randomized controlled trial.1 passage
• Screening for cardiac contractile dysfunction using an artificial intelligence-enabled electrocardiogram.1 passage
• Seasonal coronavirus protective immunity is short-lasting.1 passage
• Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension.1 passage
• Selective inhibition of the p38 alternative activation pathway in infiltrating T cells inhibits pancreatic cancer progression.1 passage
• Selective modulation of the androgen receptor AF2 domain rescues degeneration in spinal bulbar muscular atrophy.1 passage
• Selective neuronal lapses precede human cognitive lapses following sleep deprivation.1 passage
• Self-tunable engineered yeast probiotics for the treatment of inflammatory bowel disease.1 passage
• Sensitivity of infectious SARS-CoV-2 B.1.1.7 and B.1.351 variants to neutralizing antibodies.1 passage
• Sensory feedback restoration in leg amputees improves walking speed, metabolic cost and phantom pain.1 passage
• Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors.1 passage
• Seroprevalence of immunoglobulin M and G antibodies against SARS-CoV-2 in China.1 passage
• Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer's disease.1 passage
• Sex differences in cardiometabolic disorders.1 passage
• Sex-specific transcriptional signatures in human depression.1 passage
• Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus.1 passage
• Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy.1 passage
• Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response.1 passage
• Silent hippocampal seizures and spikes identified by foramen ovale electrodes in Alzheimer's disease.1 passage
• Simultaneous detection of genotype and phenotype enables rapid and accurate antibiotic susceptibility determination.1 passage
• Single cell dissection of plasma cell heterogeneity in symptomatic and asymptomatic myeloma.1 passage
• Single-arm, open-label phase 2 trial of pembrolizumab in patients with leptomeningeal carcinomatosis.1 passage
• Single-cell atlas of colonic CD81 passage
• Single-cell developmental classification of B cell precursor acute lymphoblastic leukemia at diagnosis reveals predictors of relapse.1 passage
• Single-cell dissection of intratumoral heterogeneity and lineage diversity in metastatic gastric adenocarcinoma.1 passage
• Single-cell genomic approaches for developing the next generation of immunotherapies.1 passage
• Single-cell immune landscape of human atherosclerotic plaques.1 passage
• Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19.1 passage
• Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics.1 passage
• Single-cell multi-omics analysis of the immune response in COVID-19.1 passage
• Single-cell profiling of breast cancer T cells reveals a tissue-resident memory subset associated with improved prognosis.1 passage
• Single-cell transcriptomic atlas of the human endometrium during the menstrual cycle.1 passage
• Single-cell transcriptomics uncovers distinct molecular signatures of stem cells in chronic myeloid leukemia.1 passage
• Sirtuin 1 regulates cardiac electrical activity by deacetylating the cardiac sodium channel.1 passage
• Sixteen novel lineages of SARS-CoV-2 in South Africa.1 passage
• Skin-interfaced biosensors for advanced wireless physiological monitoring in neonatal and pediatric intensive-care units.1 passage
• Slit2 signaling through Robo1 and Robo2 is required for retinal neovascularization.1 passage
• Small-molecule targeting of brachyury transcription factor addiction in chordoma.1 passage
• Somatic gene editing ameliorates skeletal and cardiac muscle failure in pig and human models of Duchenne muscular dystrophy.1 passage
• Somatic mutations precede acute myeloid leukemia years before diagnosis.1 passage
• Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells.1 passage
• Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer.1 passage
• Spinal cord reconstitution with homologous neural grafts enables robust corticospinal regeneration.1 passage
• Spinal cord repair: advances in biology and technology.1 passage
• Spinal subpial delivery of AAV9 enables widespread gene silencing and blocks motoneuron degeneration in ALS.1 passage
• State-dependent responses to intracranial brain stimulation in a patient with depression.1 passage
• Stimulating the RIG-I pathway to kill cells in the latent HIV reservoir following viral reactivation.1 passage
• Stimulation of entorhinal cortex-dentate gyrus circuitry is antidepressive.1 passage
• Stress-glucocorticoid-TSC22D3 axis compromises therapy-induced antitumor immunity.1 passage
• Structure-guided combination therapy to potently improve the function of mutant CFTRs.1 passage
• Studying clonal dynamics in response to cancer therapy using high-complexity barcoding.1 passage
• Subclonal diversification of primary breast cancer revealed by multiregion sequencing.1 passage
• Subcutaneous infusion of exenatide and cardiovascular outcomes in type 2 diabetes: a non-inferiority randomized controlled trial.1 passage
• Substantial interindividual and limited intraindividual genomic diversity among tumors from men with metastatic prostate cancer.1 passage
• Successful engraftment of gene-corrected hematopoietic stem cells in non-conditioned patients with Fanconi anemia.1 passage
• Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study.1 passage
• Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate.1 passage
• Suppression of detyrosinated microtubules improves cardiomyocyte function in human heart failure.1 passage
• Suppression of luteinizing hormone enhances HSC recovery after hematopoietic injury.1 passage
• Survival and biomarker analyses from the OpACIN-neo and OpACIN neoadjuvant immunotherapy trials in stage III melanoma.1 passage
• Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants.1 passage
• Synthetic lethal targeting of oncogenic transcription factors in acute leukemia by PARP inhibitors.1 passage
• Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers.1 passage
• Systematic discovery of complex insertions and deletions in human cancers.1 passage
• Systematic screening identifies therapeutic antisense oligonucleotides for Hutchinson-Gilford progeria syndrome.1 passage
• Systemic clinical tumor regressions and potentiation of PD1 blockade with in situ vaccination.1 passage
• Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth.1 passage
• Systemic dysfunction and plasticity of the immune macroenvironment in cancer models.1 passage
• Systemic messenger RNA as an etiological treatment for acute intermittent porphyria.1 passage
• T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial.1 passage
• T cell receptor gene therapy targeting WT1 prevents acute myeloid leukemia relapse post-transplant.1 passage
• T memory stem cells in health and disease.1 passage
• TCF1 links GIPR signaling to the control of beta cell function and survival.1 passage
• TCR-engineered T cells targeting E7 for patients with metastatic HPV-associated epithelial cancers.1 passage
• TMEM30A loss-of-function mutations drive lymphomagenesis and confer therapeutically exploitable vulnerability in B-cell lymphoma.1 passage
• Targeted therapy guided by single-cell transcriptomic analysis in drug-induced hypersensitivity syndrome: a case report.1 passage
• Targeting B cell receptor signaling with ibrutinib in diffuse large B cell lymphoma.1 passage
• Targeting CASP8 and FADD-like apoptosis regulator ameliorates nonalcoholic steatohepatitis in mice and nonhuman primates.1 passage
• Targeting CBLB as a potential therapeutic approach for disseminated candidiasis.1 passage
• Targeting CD70 with cusatuzumab eliminates acute myeloid leukemia stem cells in patients treated with hypomethylating agents.1 passage
• Targeting EZH2 in cancer.1 passage
• Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies.1 passage
• Targeting c-FOS and DUSP1 abrogates intrinsic resistance to tyrosine-kinase inhibitor therapy in BCR-ABL-induced leukemia.1 passage
• Targeting epigenetic modifications in cancer therapy: erasing the roadmap to cancer.1 passage
• Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy.1 passage
• Targeting glioma stem cells through combined BMI1 and EZH2 inhibition.1 passage
• Targeting hepatic glutaminase activity to ameliorate hyperglycemia.1 passage
• Targeting metastatic cancer.1 passage
• Targeting mitochondrial dysfunction can restore antiviral activity of exhausted HBV-specific CD8 T cells in chronic hepatitis B.1 passage
• Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells.1 passage
• Targeting of the pulmonary capillary vascular niche promotes lung alveolar repair and ameliorates fibrosis.1 passage
• Targeting skeletal endothelium to ameliorate bone loss.1 passage
• Targeting the HIF2-VEGF axis in renal cell carcinoma.1 passage
• Targeting the MLL complex in castration-resistant prostate cancer.1 passage
• Targeting the T cell receptor β-chain constant region for immunotherapy of T cell malignancies.1 passage
• Targeting the histone methyltransferase G9a activates imprinted genes and improves survival of a mouse model of Prader-Willi syndrome.1 passage
• Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition.1 passage
• Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease.1 passage
• Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling.1 passage
• Temporal dynamics in viral shedding and transmissibility of COVID-19.1 passage
• Ten recommendations for supporting open pathogen genomic analysis in public health.1 passage
• Thalamic miR-338-3p mediates auditory thalamocortical disruption and its late onset in models of 22q11.2 microdeletion.1 passage
• The Angiosarcoma Project: enabling genomic and clinical discoveries in a rare cancer through patient-partnered research.1 passage
• The Artificial Intelligence Clinician learns optimal treatment strategies for sepsis in intensive care.1 passage
• The Ashwell-Morell receptor regulates hepatic thrombopoietin production via JAK2-STAT3 signaling.1 passage
• The Cyclophilin A-CD147 complex promotes the proliferation and homing of multiple myeloma cells.1 passage
• The DNA methylation landscape of glioblastoma disease progression shows extensive heterogeneity in time and space.1 passage
• The EGFR-specific antibody cetuximab combined with chemotherapy triggers immunogenic cell death.1 passage
• The N1 passage
• The SGLT2 inhibitor dapagliflozin in heart failure with preserved ejection fraction: a multicenter randomized trial.1 passage
• The activated conformation of integrin β1 passage
• The androgen receptor is a tumor suppressor in estrogen receptor-positive breast cancer.1 passage
• The association between sterilizing activity and drug distribution into tuberculosis lesions.1 passage
• The central role of muscle stem cells in regenerative failure with aging.1 passage
• The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue.1 passage
• The consensus molecular subtypes of colorectal cancer.1 passage
• The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia.1 passage
• The deubiquitinating enzyme TNFAIP3 mediates inactivation of hepatic ASK1 and ameliorates nonalcoholic steatohepatitis.1 passage
• The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis.1 passage
• The distribution of cellular turnover in the human body.1 passage
• The effect of LRRK2 loss-of-function variants in humans.1 passage
• The effects of tobacco control policies on global smoking prevalence.1 passage
• The emerging link between cancer, metabolism, and circadian rhythms.1 passage
• The emerging role of lncRNAs in cancer.1 passage
• The emerging role of resident memory T cells in protective immunity and inflammatory disease.1 passage
• The eukaryotic gut virome in hematopoietic stem cell transplantation: new clues in enteric graft-versus-host disease.1 passage
• The exerkine apelin reverses age-associated sarcopenia.1 passage
• The gut microbiome modulates the protective association between a Mediterranean diet and cardiometabolic disease risk.1 passage
• The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development.1 passage
• The human heart contains distinct macrophage subsets with divergent origins and functions.1 passage
• The impact of school opening model on SARS-CoV-2 community incidence and mortality.1 passage
• The implications of the shared genetics of psychiatric disorders.1 passage
• The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity.1 passage
• The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease.1 passage
• The landscape of cancer cell line metabolism.1 passage
• The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy.1 passage
• The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL.1 passage
• The metabolic regulation of aging.1 passage
• The microRNA-200 family regulates pancreatic beta cell survival in type 2 diabetes.1 passage
• The microbiome in early life: implications for health outcomes.1 passage
• The microbiome, cancer, and cancer therapy.1 passage
• The molecular landscape of glioma in patients with Neurofibromatosis 1.1 passage
• The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions.1 passage
• The next phase of SARS-CoV-2 surveillance: real-time molecular epidemiology.1 passage
• The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment.1 passage
• The potential public health consequences of COVID-19 on malaria in Africa.1 passage
• The practical implementation of artificial intelligence technologies in medicine.1 passage
• The prognostic landscape of genes and infiltrating immune cells across human cancers.1 passage
• The promises and challenges of human brain organoids as models of neuropsychiatric disease.1 passage
• The pros, cons, and many unknowns of probiotics.1 passage
• The reference epigenome and regulatory chromatin landscape of chronic lymphocytic leukemia.1 passage
• The repertoire of maternal anti-viral antibodies in human newborns.1 passage
• The role of exome sequencing in newborn screening for inborn errors of metabolism.1 passage
• The search for imaging biomarkers in psychiatric disorders.1 passage
• The vaginal microbiome and preterm birth.1 passage
• Therapeutic base editing of human hematopoietic stem cells.1 passage
• Therapeutic efficacy of antisense oligonucleotides in mouse models of CLN3 Batten disease.1 passage
• Therapeutic genome editing: prospects and challenges.1 passage
• Therapeutic inhibition of mTORC2 rescues the behavioral and neurophysiological abnormalities associated with Pten-deficiency.1 passage
• Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas.1 passage
• Therapeutic targeting of splicing in cancer.1 passage
• Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling.1 passage
• Three-dimensional spatially resolved geometrical and functional models of human liver tissue reveal new aspects of NAFLD progression.1 passage
• Thymosin α1 represents a potential potent single-molecule-based therapy for cystic fibrosis.1 passage
• Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function.1 passage
• Tmbim1 is a multivesicular body regulator that protects against non-alcoholic fatty liver disease in mice and monkeys by targeting the lysosomal degradation of Tlr4.1 passage
• Toripalimab or placebo plus chemotherapy as first-line treatment in advanced nasopharyngeal carcinoma: a multicenter randomized phase 3 trial.1 passage
• Toward personalized treatment approaches for non-small-cell lung cancer.1 passage
• Toward understanding and exploiting tumor heterogeneity.1 passage
• Toward universal health coverage in the post-COVID-19 era.1 passage
• Toxicity after AAV delivery of RNAi expression constructs into nonhuman primate brain.1 passage
• Trans-biobank analysis with 676,000 individuals elucidates the association of polygenic risk scores of complex traits with human lifespan.1 passage
• Transcript-indexed ATAC-seq for precision immune profiling.1 passage
• Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4.1 passage
• Transcriptional analysis of cystic fibrosis airways at single-cell resolution reveals altered epithelial cell states and composition.1 passage
• Transcriptional mediators of treatment resistance in lethal prostate cancer.1 passage
• Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA.1 passage
• Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice.1 passage
• Transient inhibition of ROR-γt therapeutically limits intestinal inflammation by reducing TH17 cells and preserving group 3 innate lymphoid cells.1 passage
• Transitory presence of myeloid-derived suppressor cells in neonates is critical for control of inflammation.1 passage
• Translational control of tumor immune escape via the eIF4F-STAT1-PD-L1 axis in melanoma.1 passage
• Translational strategies in aging and age-related disease.1 passage
• Translational value of mouse models in oncology drug development.1 passage
• Translocation and dissemination of commensal bacteria in post-stroke infection.1 passage
• Treatment of a metabolic liver disease by in vivo genome base editing in adult mice.1 passage
• Triage-driven diagnosis of Barrett's esophagus for early detection of esophageal adenocarcinoma using deep learning.1 passage
• Tumor cells can follow distinct evolutionary paths to become resistant to epidermal growth factor receptor inhibition.1 passage
• Tumor innate immunity primed by specific interferon-stimulated endogenous retroviruses.1 passage
• Tumor necrosis factor-α confers cardioprotection through ectopic expression of keratins K8 and K18.1 passage
• Tumor-derived IFN triggers chronic pathway agonism and sensitivity to ADAR loss.1 passage
• Tumor-educated B cells selectively promote breast cancer lymph node metastasis by HSPA4-targeting IgG.1 passage
• Tumor-infiltrating lymphocyte treatment for anti-PD-1-resistant metastatic lung cancer: a phase 1 trial.1 passage
• Two FOXP3(+)CD4(+) T cell subpopulations distinctly control the prognosis of colorectal cancers.1 passage
• Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor.1 passage
• UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis.1 passage
• Ultraviolet radiation-induced DNA damage is prognostic for outcome in melanoma.1 passage
• Underdiagnosis bias of artificial intelligence algorithms applied to chest radiographs in under-served patient populations.1 passage
• Understanding the rise of cardiometabolic diseases in low- and middle-income countries.1 passage
• Understanding the tumor immune microenvironment (TIME) for effective therapy.1 passage
• Undulating changes in human plasma proteome profiles across the lifespan.1 passage
• Urocortin3 mediates somatostatin-dependent negative feedback control of insulin secretion.1 passage
• Using a real-world network to model localized COVID-19 control strategies.1 passage
• Using common genetic variation to examine phenotypic expression and risk prediction in 22q11.2 deletion syndrome.1 passage
• Using human genetics to understand the disease impacts of testosterone in men and women.1 passage
• Utility of ctDNA to support patient selection for early phase clinical trials: the TARGET study.1 passage
• VISTA is an inhibitory immune checkpoint that is increased after ipilimumab therapy in patients with prostate cancer.1 passage
• Vaccine development for emerging infectious diseases.1 passage
• Vaginal microbiome transplantation in women with intractable bacterial vaginosis.1 passage
• Valsartan in early-stage hypertrophic cardiomyopathy: a randomized phase 2 trial.1 passage
• Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia.1 passage
• Verapamil and beta cell function in adults with recent-onset type 1 diabetes.1 passage
• Vessel co-option mediates resistance to anti-angiogenic therapy in liver metastases.1 passage
• Viable bacterial colonization is highly limited in the human intestine in utero.1 passage
• Viral loads of Delta-variant SARS-CoV-2 breakthrough infections after vaccination and booster with BNT162b2.1 passage
• Viral variants that initiate and drive maturation of V1V2-directed HIV-1 broadly neutralizing antibodies.1 passage
• Visualization of AMPA receptors in living human brain with positron emission tomography.1 passage
• Wearable sensor data and self-reported symptoms for COVID-19 detection.1 passage
• Wearable sensors enable personalized predictions of clinical laboratory measurements.1 passage
• Wearable-device-measured physical activity and future health risk.1 passage
• Whole genome, transcriptome and methylome profiling enhances actionable target discovery in high-risk pediatric cancer.1 passage
• Whole-genome sequencing of quartet families with autism spectrum disorder.1 passage
• Whole-genome sequencing of triple-negative breast cancers in a population-based clinical study.1 passage
• Whole-genome single-cell copy number profiling from formalin-fixed paraffin-embedded samples.1 passage
• Wireless bioresorbable electronic system enables sustained nonpharmacological neuroregenerative therapy.1 passage
• Wiskott-Aldrich syndrome protein (WASP) is a tumor suppressor in T cell lymphoma.1 passage
• XCR11 passage
• Xenogeneic cross-circulation for extracorporeal recovery of injured human lungs.1 passage
• cGAS drives noncanonical-inflammasome activation in age-related macular degeneration.1 passage
• iPSC modeling of young-onset Parkinson's disease reveals a molecular signature of disease and novel therapeutic candidates.1 passage
• lncRNA MIR100HG-derived miR-100 and miR-125b mediate cetuximab resistance via Wnt/β-catenin signaling.1 passage
• mRNA-1273 COVID-19 vaccine effectiveness against the B.1.1.7 and B.1.351 variants and severe COVID-19 disease in Qatar.1 passage
• p16(Ink4a)-induced senescence of pancreatic beta cells enhances insulin secretion.1 passage
• p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity.1 passage
• p53 inhibits CRISPR-Cas9 engineering in human pluripotent stem cells.1 passage
• α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies.1 passage
• β2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis.1 passage