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Untangling the complex relationship between dietary acid load and glucocorticoid metabolism. The kidney's maintenance of the metabolic component of acid-base homeostasis is critical for normal health. The study by Esche and colleagues in this issue of Kidney International shows that normal children with higher levels of renal net acid excretion and of dietary acid loads have stimulation of glucocorticoid hormone metabolism. Thus, normal variations in dietary acid intake and renal net acid excretion have important biological correlates.