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Walk the evidence base by book and chapter — the raw source passages that ground Ask, Differential, and the rest.
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Practical management of C3 glomerulopathy and Ig-mediated MPGN: facts and uncertainties. In recent years, a substantial body of experimental and clinical work has been devoted to C3 glomerulopathy and Ig-mediated membranoproliferative glomerulonephritis. Despite the rapid accumulation of data, several uncertainties about these 2 rare forms of nephropathies persist. They concern their pathophysiology, classification, clinical course, relevance of biomarkers and of pathology findings, and assessment of the efficacy of the available therapies. The present review discusses the impact of these uncertainties on the clinical management of patients.