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New GFR-estimating equations for children and young adults in North America and Europe. For application to general populations, estimating equations for glomerular filtration rate should be developed and validated in diverse populations, including a wide range of age, race-ethnicity, and clinical conditions. This issue includes reports on the development of new equations by 2 research groups to improve glomerular filtration rate estimation in children and young adults. Both equations performed better than guideline-recommended equations, but both require further evaluation of generalizability, and neither fulfills the goal of development in a diverse population.