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Intensive Care Med Intensive Care Med Intensive Care Medicine 0342-4642 1432-1238 Springer-Verlag Berlin/Heidelberg 1527254 BF01706469 10.1007/BF01706469 Review Article The role of blood microfilters in clinical practice Kapadia F. 1 Valentine S. 1 Smith G. 1 1 grid.415470.30000000403920072Department of Anaesthetics, Queen Alexandra Hospital, Portsmouth, Hants UK 2 grid.123047.30000000103590315Present Address: Department of Anaesthetics, Southampton General Hospital, Tremona Road, SO9 4XY Southampton, UK 1992 18 5 258 263 18 10 1991 14 4 1992 © Springer-Verlag 1992This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.Blood filters have been available since the 1930s. In this review we evaluate the role of microaggregate filters (MF) in certain transfusion complications, namely non-haemolytic febrile transfusion reactions (NHFTR), pulmonary injury, thrombocytopenia, fibronectin depletion and histamine release. We review the latest generation of leucocyte depleting filters and discuss their role in preventing alloimmunisation, immunosuppression and CMV transmission. Finally, we provide a rationale for the role of blood microfiltration in the present day practice of intensive care medicine. Key words Microaggregate blood filtersMicroaggregatesLeucocyte-depleting filtersissue-copyright-statement© Springer-Verlag 1992