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Intensive Care Med Intensive Care Med Intensive Care Medicine 0342-4642 1432-1238 Springer-Verlag Berlin/Heidelberg 2289989 BF01709699 10.1007/BF01709699 Article Mediators of multiple organ failure Goris R. J. A. grid.10417.330000000404449382Department of General Surgery, University Hospital St. Radboud, NL-6500 HB Nijmegen, The Netherlands 1990 16 Suppl 3 S192 S196 © Springer-Verlag 1990This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.Multiple Organ Failure (MOF) has largely been attributed to bacterial sepsis, though conclusive evidence of an essential role for bacteria and/or their endotoxins is still lacking. On the other hand, MOF and the clinical syndrome of sepsis may be aseptically induced in germfree animals. This paper reviews the evidence that excessive activation of endogenous humoral mediators and inflammatory cells may cause this highly lethal syndrome. Key words Multiple organ failureARDSSepsisComplementElastaseNeopterinissue-copyright-statement© Springer-Verlag 1990