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Therapeutic Plasma Exchange in Children - Experience From a Tertiary Care Center. OBJECTIVE: To assess the safety, efficacy and outcomes of therapeutic plasma exchange (TPE) in children. METHODS: Data was retrieved from hospital records for all children ≤18 years who underwent TPE between August, 2011 and July, 2018. RESULTS: 46 children [median (range) age 96 (8-204) months] underwent 293 sessions of TPE by membrane plasma separation technique. Renal disease was the commonest indication (24, 52.2%) followed by neurological illnesses (17;36.9%). 36 (78.2%) patients belonged to American Society for Apheresis category I. Overall, the most common indication was atypical hemolytic uremic syndrome (16;34.8%). Fresh frozen plasma plus albumin was used as replacement fluid in aHUS, while albumin was used in others. 40 (86.9%) patients had complete/partial recovery while six did not show any sign of recovery. Complications were seen in 21 (7.1%) sessions; majority of which were minor in the form of blood pressure fluctuations. CONCLUSION: TPE can be performed safely and effectively for renal and non-renal indications, even in small children.