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Reversible Cerebral Atrophy in Infantile Tremor Syndrome. BACKGROUND: We report changes in MRI brain of children with Infantile Tremor Syndrome (ITS) at the onset of illness and following treatment. CASE CHARACTERISTICS: Three children with infantile tremor syndrome were assessed for changes in brain neuroimaging at admission and at follow-up visit. On MRI, all children had mild to severe diffuse cerebral atrophy, which reverted back to normal on follow-up visits. OUTCOME: Children with infantile tremor syndrome have reversible diffuse cerebral atrophy on neuroimaging.