Browse the corpus
Walk the evidence base by book and chapter — the raw source passages that ground Ask, Differential, and the rest.
1 passage
Oral Sildenafil for Severe Pulmonary Hypertension Developing after Ibuprofen Use in a Neonate. BACKGROUND: Severe pulmonary hypertension may following ibuprofen administration for ductal closure. CASE CHARACTERISTICS: An extremely preterm infant who developed severe pulmonary hypertension unresponsive to inhaled nitric oxide after ibuprofen administration. OUTCOME: Pulmonary hypertension reversed after the administration of oral sildenafil, but the infant died due to complications related to bronchopulmonary dysplasia. MESSAGE: Sildenafil may have a role in treatment of severe pulmonary hypertension after ibuprofen treatment for ductal closure.