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Multiple Pituitary Hormone Deficiency, Empty Sella and Ectopic Neurohypophysis in Turner Syndrome. BACKGROUND: Multiple pituitary hormone deficiency and Turner syndrome have overlapping features in peripubertal girls and is a diagnostic challenge. CASE CHARACTERISTICS: 16-year-old girl having Turner phenotype undergoing evaluation for severe short stature and pubertal arrest. OBSERVATION: 45,X karyotype, and multiple pituitary hormone deficiency with empty sella. INTERVENTION: Levothyroxine, growth hormone and ethinyl-estradiol replacement resulted in 11 cm height gain with attainment of puberty over 2 years. MESSAGE: Patients of Turner syndrome with height <3rd percentile (Turner specific charts) warrant additional pathology evaluation.