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Gastrointestinal Neuroendocrine Tumors in Two Children. BACKGROUND: Enterochromaffin-like cell hyperplasia and neuroendocrine tumors are relatively rare in childhood. CASE CHARACTERISTICS: A 15-year-old girl who presented with epigastric pain and a 6-year-old boy who was admitted with hematochezia. Endoscopy revealed nodules in the stomach in Case 1, and polyploidy lesion in the rectum in Case 2. OUTCOME: Enterochromaffin-like cell hyperplasia in Case 1 and neuroendocrine tumor in Case 2. MESSAGE: A low index of suspicion for neuroendocrine tumors in children can result in delay in the detection of these rare but potentially malignant diseases.