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Academic stress and depression among adolescents: a cross-sectional study. OBJECTIVE: To examine the relationship between academic stress and depression among adolescents. METHODS: A cross-sectional study was conducted at higher secondary schools in Tamil Nadu. 1120 adolescents were included in the study after screening by MINI-kid tool. Modified Educatonal Stress Scale for Adolescents was administered to all children. RESULTS: Adolescents who had academic stress were at 2.4 times (95% CI=0.9-2.4) (P<0.001) higher risk of depression than adolescents without academic stress. CONCLUSIONS: Adolescents with severe academic stress need to be identified early as interventions to reduce academic stress is likely to affect the occurrence and severity of depression.