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A Rare Cause of Swelling and Pain in Extremities in Children: Complex Regional Pain Syndrome. Complex regional pain syndrome is a condition of uncertain etiology characterized by spontaneous or stimulus-induced pain that is out of proportion to the inciting event. We report a 14-year-7-month-old girl with swelling of the left hand and wrist, was diagnosed as complex regional pain syndrome. The patient was treated successfully with physical therapy and non-steroidal anti-inflammatory drugs. This condition should be kept in mind in the differential diagnosis of musculoskeletal non-inflammatory and inflammatory pains.