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INTRODUCTION Tetanus is a life-threatening and serious infectious disease with a high morbidity and mortality if left untreated.[1] Clostridium tetani is a gram-positive bacillus producing tetanospasmin, the toxin leading to its disabling and fatal manifestations.[2] Generalized tetanus is the most classical form. However, atypical patterns of presentation including cephalic and rarely localized tetanus may prove to be difficult diagnoses to arrive to, in view of its unusual presentation.[3] Looking into the journals and scientific literature, we can find very few publications related to localized tetanus in human. Hence, this case report becomes important to impart knowledge to treating doctors in Intensive Care Units to learn features of localized tetanus for early recognition and need for prompt diagnosis and treatment.

journals and scientific literature, we can find very few publications related to localized tetanus in human. Hence, this case report becomes important to impart knowledge to treating doctors in Intensive Care Units to learn features of localized tetanus for early recognition and need for prompt diagnosis and treatment. CASE REPORT A 55-year-old male farmer presented with history of an injury to the left toe 7 days before presentation, followed by recent onset of fever, chills, and headache [Figure 1]. He took treatment with a local doctor and within 24 h developed complaints of pain in the left lower limb associated with intermittent muscle spasms involving left lower limbs [Figure 2]. On complete neurological examination, there were no features of bowel/bladder involvement, alteration of sensorium, or signs of generalized tetanus such as trismus (lockjaw), muscle pain and stiffness, back pain, opisthotonus, or difficulty in swallowing. He did not have any history of immunization. Furthermore, he did not give any history of ingestion of poisonous substances or any alternative medications. On laboratory blood investigations, he was found to have leukocytosis, with normal renal and liver function with elevated C-reactive protein. Radiographic imaging of the hip, knee, and ankles of the right and left limbs was normal. In view of spasmodic contractions localized mainly to the left lower limb, a prompt diagnosis of localized tetanus was made and immediately human tetanus immunoglobulins, 1000 IU IM, were given to the patient to neutralize the circulating toxins. Surgical management of the wound was carried out urgently, along with administration of tetanus toxoid (TT). For muscle spasm, diazepam infusion of 1 mg/kg/day was given with which his spasm subsided and was tapered within 3 days and switch to oral form. He did not have any further worsening. He did not require tracheostomy since spasm did not generalize. Cephalosporin and metronidazole were given as antibiotic coverage. He was discharged in 7 days and has been followed up to look for response. He is stable, with no residual deficit on 6-month follow-up.

to oral form. He did not have any further worsening. He did not require tracheostomy since spasm did not generalize. Cephalosporin and metronidazole were given as antibiotic coverage. He was discharged in 7 days and has been followed up to look for response. He is stable, with no residual deficit on 6-month follow-up. Figure 1 Left toe wound Figure 2 Muscle spasm involving left lower limb DISCUSSION C. tetani is an anaerobic bacterium found commonly in soil in spore form or in the gastrointestinal tracts of mammals and produces a potent neurotoxin, tetanospasmin. Incubation period ranges from 3 to 21 days, with most average incubation period being 10 days. Tetanospasmin causes violent spastic paralysis by blocking the release of γ-aminobutyric acid, inhibitory neurotransmitter acting on motor neurons.[3] Localized tetanus is rarely reported in literature, and to the best of our knowledge, only three to four cases of localized tetanus have been reported in the last decade.[34] The diagnosis of tetanus is mainly clinical, which may not be difficult in a case of generalized tetanus. However, a case of localized or cephalic tetanus has a varied presentation and may be difficult to distinguish from a local disorder involving the joints or a hysterical disorder.[3] A retrospective analysis done in 2001 by Kakou et al. showed a cure rate of 82% with 16% mortality in 37 cases reported of tetanus in the last 22 years.[3]

Localized tetanus is rarely reported in literature, and to the best of our knowledge, only three to four cases of localized tetanus have been reported in the last decade.[34] The diagnosis of tetanus is mainly clinical, which may not be difficult in a case of generalized tetanus. However, a case of localized or cephalic tetanus has a varied presentation and may be difficult to distinguish from a local disorder involving the joints or a hysterical disorder.[3] A retrospective analysis done in 2001 by Kakou et al. showed a cure rate of 82% with 16% mortality in 37 cases reported of tetanus in the last 22 years.[3] In another case report, a child had developed localized tetanus following immune globulin injection and was managed with TT immunoglobulin and intravenous benzylpenicillin and recovered within 2 weeks.[3] Furthermore, there have been case reports of localized tetanus in cats with recovery with supportive therapy.[5] Localized tetanus has a good cure rate generally, and hence, aggressive management is required to prevent generalization. Management principles include neutralization of the toxin with tetanus immunoglobulin, as well as debridement of the wound. Choice of antibiotic is metronidazole. An alternative is penicillin (100,000–200,000 IU/kg/day), although it may exacerbate spasms.[6] The patient should be given a complete primary course of immunization, as tetanus toxin is poorly immunogenic and the immune response following natural infection is inadequate.[6]

Localized tetanus has a good cure rate generally, and hence, aggressive management is required to prevent generalization. Management principles include neutralization of the toxin with tetanus immunoglobulin, as well as debridement of the wound. Choice of antibiotic is metronidazole. An alternative is penicillin (100,000–200,000 IU/kg/day), although it may exacerbate spasms.[6] The patient should be given a complete primary course of immunization, as tetanus toxin is poorly immunogenic and the immune response following natural infection is inadequate.[6] Declaration of patient consent The authors certify that they have obtained all appropriate patient consent forms. In the form, the patient has given his consent for his images and other clinical information to be reported in the journal. The patient understands that name and initial will not be published and due efforts will be made to conceal identity, but anonymity cannot be guaranteed. Financial support and sponsorship Nil. Conflicts of interest There are no conflicts of interest.