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Development of a Novel Endoscopic Manipulation System: The Endoscopic Operation Robot ver. 2. BACKGROUND/AIMS: The Endoscopic Operation Robot (EOR) ver. 1 was developed in order to provide robotized operational support for flexible endoscopes, which can be complicated to manipulate. However, total colonoscopy examinations with a colonoscopy training model by proficient operation of the joystick using the EOR ver. 1 took about 6 times longer to reach the cecum than with current manual operation. Thus, EOR ver. 2 is a newly developed robot. METHODOLOGY: The time required total colonoscopy examinations with a colonoscopy training model was performed compared using the EOR ver. 1 and using the EOR ver. 2. RESULTS: The median insertion time (in minutes) was 17.20 ± 3.92 in the EOR ver. 1 group and 9.30 ± 2.13 in the EOR ver. 2 group (p < 0.05). CONCLUSION: The study suggested the possibility of the clinical application Of the EOR.