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Walk the evidence base by book and chapter — the raw source passages that ground Ask, Differential, and the rest.

• 3-month versus 6-month adjuvant chemotherapy for patients with high-risk stage II and III colorectal cancer: 3-year follow-up of the SCOT non-inferiority RCT.1 passage
• A Very Early Rehabilitation Trial after stroke (AVERT): a Phase III, multicentre, randomised controlled trial.1 passage
• A behaviour change package to prevent hand dermatitis in nurses working in health care: the SCIN cluster RCT.1 passage
• A bespoke smoking cessation service compared with treatment as usual for people with severe mental ill health: the SCIMITAR+ RCT.1 passage
• A case management occupational health model to facilitate earlier return to work of NHS staff with common mental health disorders: a feasibility study.1 passage
• A cluster randomised trial of strategies to increase cervical screening uptake at first invitation (STRATEGIC).1 passage
• A cluster randomised trial, cost-effectiveness analysis and psychosocial evaluation of insulin pump therapy compared with multiple injections during flexible intensive insulin therapy for type 1 diabetes: the REPOSE Trial.1 passage
• A contingency management intervention to reduce cannabis use and time to relapse in early psychosis: the CIRCLE RCT.1 passage
• A cost-effectiveness modelling study of strategies to reduce risk of infection following primary hip replacement based on a systematic review.1 passage
• A feasibility randomised controlled trial of a motivational interviewing-based intervention for weight loss maintenance in adults.1 passage
• A feasibility study to inform the design of a randomised controlled trial to identify the most clinically effective and cost-effective length of Anticoagulation with Low-molecular-weight heparin In the treatment of Cancer-Associated Thrombosis (ALICAT).1 passage
• A group intervention to improve quality of life for people with advanced dementia living in care homes: the Namaste feasibility cluster RCT.1 passage
• A group memory rehabilitation programme for people with traumatic brain injuries: the ReMemBrIn RCT.1 passage
• A high-dose 24-hour tranexamic acid infusion for the treatment of significant gastrointestinal bleeding: HALT-IT RCT.1 passage
• A manual-based intervention for carers of people with dementia and sleep disturbances: an acceptability and feasibility RCT.1 passage
• A multicentre randomiSed controlled TRial of IntraVEnous immunoglobulin compared with standard therapy for the treatment of transverse myelitis in adults and children (STRIVE).1 passage
• A multicentre randomised controlled trial and economic evaluation of continuous positive airway pressure for the treatment of obstructive sleep apnoea syndrome in older people: PREDICT.1 passage
• A multicentre randomised controlled trial of Transfusion Indication Threshold Reduction on transfusion rates, morbidity and health-care resource use following cardiac surgery (TITRe2).1 passage
• A multicentre, randomised controlled trial comparing the clinical effectiveness and cost-effectiveness of early nutritional support via the parenteral versus the enteral route in critically ill patients (CALORIES).1 passage
• A multicentre, randomised controlled trial of position during the late stages of labour in nulliparous women with an epidural: clinical effectiveness and an economic evaluation (BUMPES).1 passage
• A novel peer-support intervention using motivational interviewing for breastfeeding maintenance: a UK feasibility study.1 passage
• A pedometer-based walking intervention in 45- to 75-year-olds, with and without practice nurse support: the PACE-UP three-arm cluster RCT.1 passage
• A pilot randomised controlled trial of community-led ANtipsychotic Drug REduction for Adults with Learning Disabilities.1 passage
• A pragmatic multicentre randomised controlled trial comparing stapled haemorrhoidopexy with traditional excisional surgery for haemorrhoidal disease: the eTHoS study.1 passage
• A pragmatic randomised controlled trial and economic evaluation of family therapy versus treatment as usual for young people seen after second or subsequent episodes of self-harm: the Self-Harm Intervention - Family Therapy (SHIFT) trial.1 passage
• A prognostic model to guide decision-making on timing of delivery in late preterm pre-eclampsia: the PEACOCK prospective cohort study.1 passage
• A prognostic model, including quantitative fetal fibronectin, to predict preterm labour: the QUIDS meta-analysis and prospective cohort study.1 passage
• A programme of studies including assessment of diagnostic accuracy of school hearing screening tests and a cost-effectiveness model of school entry hearing screening programmes.1 passage
• A randomised controlled study of the effectiveness of breathing retraining exercises taught by a physiotherapist either by instructional DVD or in face-to-face sessions in the management of asthma in adults.1 passage
• A randomised controlled trial and cost-effectiveness analysis of high-frequency oscillatory ventilation against conventional artificial ventilation for adults with acute respiratory distress syndrome. The OSCAR (OSCillation in ARDS) study.1 passage
• A randomised controlled trial and economic evaluation of intraoperative cell salvage during caesarean section in women at risk of haemorrhage: the SALVO (cell SALVage in Obstetrics) trial.1 passage
• A randomised controlled trial of Outpatient versus inpatient Polyp Treatment (OPT) for abnormal uterine bleeding.1 passage
• A randomised controlled trial of computerised cognitive behaviour therapy for the treatment of depression in primary care: the Randomised Evaluation of the Effectiveness and Acceptability of Computerised Therapy (REEACT) trial.1 passage
• A randomised controlled trial of the clinical effectiveness and cost-effectiveness of the levonorgestrel-releasing intrauterine system in primary care against standard treatment for menorrhagia: the ECLIPSE trial.1 passage
• A randomised controlled trial of the probiotic Bifidobacterium breve BBG-001 in preterm babies to prevent sepsis, necrotising enterocolitis and death: the Probiotics in Preterm infantS (PiPS) trial.1 passage
• A randomised controlled trial to assess the clinical effectiveness and cost-effectiveness of alternative treatments to Inhibit VEGF in Age-related choroidal Neovascularisation (IVAN).1 passage
• A randomised controlled trial to assess the cost-effectiveness of intensive versus no scheduled follow-up in patients who have undergone resection for colorectal cancer with curative intent.1 passage
• A randomised controlled trial to compare the safety, effectiveness and cost-effectiveness of doxycycline (200 mg/day) with that of oral prednisolone (0.5 mg/kg/day) for initial treatment of bullous pemphigoid: the Bullous Pemphigoid Steroids and Tetracyclines (BLISTER) trial.1 passage
• A randomised controlled trial to measure the effects and costs of a dental caries prevention regime for young children attending primary care dental services: the Northern Ireland Caries Prevention In Practice (NIC-PIP) trial.1 passage
• A randomised placebo-controlled trial of oral and topical antibiotics for children with clinically infected eczema in the community: the ChildRen with Eczema, Antibiotic Management (CREAM) study.1 passage
• A randomised trial of the effect and cost-effectiveness of early intensive multifactorial therapy on 5-year cardiovascular outcomes in individuals with screen-detected type 2 diabetes: the Anglo-Danish-Dutch Study of Intensive Treatment in People with Screen-Detected Diabetes in Primary Care (ADDITION-Europe) study.1 passage
• A scoping study to explore the cost-effectiveness of next-generation sequencing compared with traditional genetic testing for the diagnosis of learning disabilities in children.1 passage
• A self-management programme to reduce falls and improve safe mobility in people with secondary progressive MS: the BRiMS feasibility RCT.1 passage
• A study of cellular counting to determine minimum thresholds for adequacy for liquid-based cervical cytology using a survey and counting protocol.1 passage
• A support package for parents of excessively crying infants: development and feasibility study.1 passage
• A systematic review and economic evaluation of adalimumab and dexamethasone for treating non-infectious intermediate uveitis, posterior uveitis or panuveitis in adults.1 passage
• A systematic review and economic evaluation of bisphosphonates for the prevention of fragility fractures.1 passage
• A systematic review and economic evaluation of exercise referral schemes in primary care: a short report.1 passage
• A systematic review and economic evaluation of intraoperative tests [RD-100i one-step nucleic acid amplification (OSNA) system and Metasin test] for detecting sentinel lymph node metastases in breast cancer.1 passage
• A systematic review and individual patient data meta-analysis of prognostic factors for foot ulceration in people with diabetes: the international research collaboration for the prediction of diabetic foot ulcerations (PODUS).1 passage
• A systematic review of the clinical effectiveness and cost-effectiveness of pharmacological and psychological interventions for the management of obsessive-compulsive disorder in children/adolescents and adults.1 passage
• A systematic review, evidence synthesis and meta-analysis of quantitative and qualitative studies evaluating the clinical effectiveness, the cost-effectiveness, safety and acceptability of interventions to prevent postnatal depression.1 passage
• A video-feedback parenting intervention to prevent enduring behaviour problems in at-risk children aged 12-36 months: the Healthy Start, Happy Start RCT.1 passage
• A web-based, peer-supported self-management intervention to reduce distress in relatives of people with psychosis or bipolar disorder: the REACT RCT.1 passage
• AVURT: aspirin versus placebo for the treatment of venous leg ulcers - a Phase II pilot randomised controlled trial.1 passage
• Abdominal massage plus advice, compared with advice only, for neurogenic bowel dysfunction in MS: a RCT.1 passage
• Ablative therapy for people with localised prostate cancer: a systematic review and economic evaluation.1 passage
• Acceptance and commitment therapy for older people with treatment-resistant generalised anxiety disorder: the FACTOID feasibility study.1 passage
• Accuracy of fundus autofluorescence imaging for the diagnosis and monitoring of retinal conditions: a systematic review.1 passage
• Accurate diagnosis of latent tuberculosis in children, people who are immunocompromised or at risk from immunosuppression and recent arrivals from countries with a high incidence of tuberculosis: systematic review and economic evaluation.1 passage
• Active Treatment for Idiopathic Adolescent Scoliosis (ACTIvATeS): a feasibility study.1 passage
• Active monitoring, radical prostatectomy and radical radiotherapy in PSA-detected clinically localised prostate cancer: the ProtecT three-arm RCT.1 passage
• Adalimumab in combination with methotrexate for refractory uveitis associated with juvenile idiopathic arthritis: a RCT.1 passage
• Adalimumab, etanercept and ustekinumab for treating plaque psoriasis in children and young people: systematic review and economic evaluation.1 passage
• Adalimumab, etanercept, infliximab, certolizumab pegol, golimumab, tocilizumab and abatacept for the treatment of rheumatoid arthritis not previously treated with disease-modifying antirheumatic drugs and after the failure of conventional disease-modifying antirheumatic drugs only: systematic review and economic evaluation.1 passage
• Adding emollient bath additives to standard eczema management for children with eczema: the BATHE RCT.1 passage
• Adding web-based behavioural support to exercise referral schemes for inactive adults with chronic health conditions: the e-coachER RCT.1 passage
• Adjunctive colposcopy technologies for assessing suspected cervical abnormalities: systematic reviews and economic evaluation.1 passage
• Adjunctive rifampicin to reduce early mortality from Staphylococcus aureus bacteraemia: the ARREST RCT.1 passage
• Adrenaline to improve survival in out-of-hospital cardiac arrest: the PARAMEDIC2 RCT.1 passage
• Aerobic and strength training exercise programme for cognitive impairment in people with mild to moderate dementia: the DAPA RCT.1 passage
• Alpha-2 agonists for sedation of mechanically ventilated adults in intensive care units: a systematic review.1 passage
• Alternative tumour necrosis factor inhibitors (TNFi) or abatacept or rituximab following failure of initial TNFi in rheumatoid arthritis: the SWITCH RCT.1 passage
• Amaze: a double-blind, multicentre randomised controlled trial to investigate the clinical effectiveness and cost-effectiveness of adding an ablation device-based maze procedure as an adjunct to routine cardiac surgery for patients with pre-existing atrial fibrillation.1 passage
• Amisulpride augmentation in clozapine-unresponsive schizophrenia (AMICUS): a double-blind, placebo-controlled, randomised trial of clinical effectiveness and cost-effectiveness.1 passage
• Amisulpride for very late-onset schizophrenia-like psychosis: the ATLAS three-arm RCT.1 passage
• Amoxicillin duration and dose for community-acquired pneumonia in children: the CAP-IT factorial non-inferiority RCT.1 passage
• An Occupational Therapy intervention for residents with stroke-related disabilities in UK Care Homes (OTCH): cluster randomised controlled trial with economic evaluation.1 passage
• An evaluation of the effect of an angiotensin-converting enzyme inhibitor on the growth rate of small abdominal aortic aneurysms: a randomised placebo-controlled trial (AARDVARK).1 passage
• An extended stroke rehabilitation service for people who have had a stroke: the EXTRAS RCT.1 passage
• An external pilot study to test the feasibility of a randomised controlled trial comparing eye muscle surgery against active monitoring for childhood intermittent exotropia [X(T)].1 passage
• An interactive website to aid young women's choice of contraception: feasibility and efficacy RCT.1 passage
• An intervention for parents with severe personality difficulties whose children have mental health problems: a feasibility RCT.1 passage
• An intervention to improve outcomes of falls in dementia: the DIFRID mixed-methods feasibility study.1 passage
• An intervention to improve the quality of life in children of parents with serious mental illness: the Young SMILES feasibility RCT.1 passage
• An observational study of Donor Ex Vivo Lung Perfusion in UK lung transplantation: DEVELOP-UK.1 passage
• An observational study to assess if automated diabetic retinopathy image assessment software can replace one or more steps of manual imaging grading and to determine their cost-effectiveness.1 passage
• An open randomised study of autoinflation in 4- to 11-year-old school children with otitis media with effusion in primary care.1 passage
• Anaesthetic-analgesic ear drops to reduce antibiotic consumption in children with acute otitis media: the CEDAR RCT.1 passage
• Anal fistula plug versus surgeon's preference for surgery for trans-sphincteric anal fistula: the FIAT RCT.1 passage
• Annual mammographic screening to reduce breast cancer mortality in women from age 40 years: long-term follow-up of the UK Age RCT.1 passage
• AntiEpileptic drug Monitoring in PREgnancy (EMPiRE): a double-blind randomised trial on effectiveness and acceptability of monitoring strategies.1 passage
• Antidepressant Controlled Trial For Negative Symptoms In Schizophrenia (ACTIONS): a double-blind, placebo-controlled, randomised clinical trial.1 passage
• Antidepressant medication to prevent depression relapse in primary care: the ANTLER RCT.1 passage
• Antimicrobial-impregnated central venous catheters for preventing neonatal bloodstream infection: the PREVAIL RCT.1 passage
• Aquatic therapy for children with Duchenne muscular dystrophy: a pilot feasibility randomised controlled trial and mixed-methods process evaluation.1 passage
• Assessing prognosis and prediction of treatment response in early rheumatoid arthritis: systematic reviews.1 passage
• Assessing the performance of methodological search filters to improve the efficiency of evidence information retrieval: five literature reviews and a qualitative study.1 passage
• Assistive technology and telecare to maintain independent living at home for people with dementia: the ATTILA RCT.1 passage
• Autologous chondrocyte implantation in the knee: systematic review and economic evaluation.1 passage
• Automated imaging technologies for the diagnosis of glaucoma: a comparative diagnostic study for the evaluation of the diagnostic accuracy, performance as triage tests and cost-effectiveness (GATE study).1 passage
• Automated tests for diagnosing and monitoring cognitive impairment: a diagnostic accuracy review.1 passage
• Avatrombopag and lusutrombopag for thrombocytopenia in people with chronic liver disease needing an elective procedure: a systematic review and cost-effectiveness analysis.1 passage
• Axitinib, cabozantinib, everolimus, nivolumab, sunitinib and best supportive care in previously treated renal cell carcinoma: a systematic review and economic evaluation.1 passage
• BREATHER (PENTA 16) short-cycle therapy (SCT) (5 days on/2 days off) in young people with chronic human immunodeficiency virus infection: an open, randomised, parallel-group Phase II/III trial.1 passage
• Bariatric surgery, lifestyle interventions and orlistat for severe obesity: the REBALANCE mixed-methods systematic review and economic evaluation.1 passage
• Barriers to and facilitators of smoking cessation in pregnancy and following childbirth: literature review and qualitative study.1 passage
• Basic versus biofeedback-mediated intensive pelvic floor muscle training for women with urinary incontinence: the OPAL RCT.1 passage
• Behaviour change techniques: the development and evaluation of a taxonomic method for reporting and describing behaviour change interventions (a suite of five studies involving consensus methods, randomised controlled trials and analysis of qualitative data).1 passage
• Behavioural activation therapy for post-stroke depression: the BEADS feasibility RCT.1 passage
• Behavioural activation versus guided self-help for depression in adults with learning disabilities: the BeatIt RCT.1 passage
• Behavioural modification interventions for medically unexplained symptoms in primary care: systematic reviews and economic evaluation.1 passage
• Benefits of Incentives for Breastfeeding and Smoking cessation in pregnancy (BIBS): a mixed-methods study to inform trial design.1 passage
• Best-practice prevention alone or with conventional or biological caries management for 3- to 7-year-olds: the FiCTION three-arm RCT.1 passage
• Bisphosphonates to reduce bone fractures in stage 3B+ chronic kidney disease: a propensity score-matched cohort study.1 passage
• Bladder ultrasonography for diagnosing detrusor overactivity: test accuracy study and economic evaluation.1 passage
• Blinded randomised controlled trial of low-dose Adjuvant Steroids in Adults admitted to hospital with Pandemic influenza (ASAP): a trial 'in hibernation', ready for rapid activation.1 passage
• Brain and spinal stimulation therapies for phantom limb pain: a systematic review.1 passage
• Bronchiolitis of Infancy Discharge Study (BIDS): a multicentre, parallel-group, double-blind, randomised controlled, equivalence trial with economic evaluation.1 passage
• C-reactive protein point-of-care testing for safely reducing antibiotics for acute exacerbations of chronic obstructive pulmonary disease: the PACE RCT.1 passage
• CATheter Infections in CHildren (CATCH): a randomised controlled trial and economic evaluation comparing impregnated and standard central venous catheters in children.1 passage
• Cabozantinib and vandetanib for unresectable locally advanced or metastatic medullary thyroid cancer: a systematic review and economic model.1 passage
• Calculating when elective abdominal aortic aneurysm repair improves survival for individual patients: development of the Aneurysm Repair Decision Aid and economic evaluation.1 passage
• Can text messages increase safer sex behaviours in young people? Intervention development and pilot randomised controlled trial.1 passage
• Canagliflozin, dapagliflozin and empagliflozin monotherapy for treating type 2 diabetes: systematic review and economic evaluation.1 passage
• Cancer diagnostic tools to aid decision-making in primary care: mixed-methods systematic reviews and cost-effectiveness analysis.1 passage
• Cardiovascular disease risk communication in NHS Health Checks using QRISK®2 and JBS3 risk calculators: the RICO qualitative and quantitative study.1 passage
• Carer administration of as-needed subcutaneous medication for breakthrough symptoms in people dying at home: the CARiAD feasibility RCT.1 passage
• Carotid artery stenting compared with endarterectomy in patients with symptomatic carotid stenosis (International Carotid Stenting Study): a randomised controlled trial with cost-effectiveness analysis.1 passage
• Certolizumab pegol and secukinumab for treating active psoriatic arthritis following inadequate response to disease-modifying antirheumatic drugs: a systematic review and economic evaluation.1 passage
• Clinical effectiveness and cost-effectiveness of a multifaceted podiatry intervention for falls prevention in older people: a multicentre cohort randomised controlled trial (the REducing Falls with ORthoses and a Multifaceted podiatry intervention trial).1 passage
• Clinical effectiveness and cost-effectiveness of beta-interferon and glatiramer acetate for treating multiple sclerosis: systematic review and economic evaluation.1 passage
• Clinical effectiveness and cost-effectiveness of body psychotherapy in the treatment of negative symptoms of schizophrenia: a multicentre randomised controlled trial.1 passage
• Clinical effectiveness and cost-effectiveness of collaborative care for depression in UK primary care (CADET): a cluster randomised controlled trial.1 passage
• Clinical effectiveness and cost-effectiveness of elemental nutrition for the maintenance of remission in Crohn's disease: a systematic review and meta-analysis.1 passage
• Clinical effectiveness and cost-effectiveness of foam sclerotherapy, endovenous laser ablation and surgery for varicose veins: results from the Comparison of LAser, Surgery and foam Sclerotherapy (CLASS) randomised controlled trial.1 passage
• Clinical effectiveness and cost-effectiveness of interventions for the treatment of anogenital warts: systematic review and economic evaluation.1 passage
• Clinical effectiveness and cost-effectiveness of issuing longer versus shorter duration (3-month vs. 28-day) prescriptions in patients with chronic conditions: systematic review and economic modelling.1 passage
• Clinical effectiveness and cost-effectiveness of open and arthroscopic rotator cuff repair [the UK Rotator Cuff Surgery (UKUFF) randomised trial].1 passage
• Clinical effectiveness and cost-effectiveness of parenting interventions for children with severe attachment problems: a systematic review and meta-analysis.1 passage
• Clinical effectiveness and cost-effectiveness of physiotherapy and occupational therapy versus no therapy in mild to moderate Parkinson's disease: a large pragmatic randomised controlled trial (PD REHAB).1 passage
• Clinical effectiveness and cost-effectiveness of surgical options for the management of anterior and/or posterior vaginal wall prolapse: two randomised controlled trials within a comprehensive cohort study - results from the PROSPECT Study.1 passage
• Clinical effectiveness and cost-effectiveness of use of therapeutic monitoring of tumour necrosis factor alpha (TNF-α) inhibitors [LISA-TRACKER® enzyme-linked immunosorbent assay (ELISA) kits, TNF-α-Blocker ELISA kits and Promonitor® ELISA kits] versus standard care in patients with Crohn's disease: systematic reviews and economic modelling.1 passage
• Clinical effectiveness and cost-effectiveness results from the randomised, Phase IIB trial in previously untreated patients with chronic lymphocytic leukaemia to compare fludarabine, cyclophosphamide and rituximab with fludarabine, cyclophosphamide, mitoxantrone and low-dose rituximab: the Attenuated dose Rituximab with ChemoTherapy In Chronic lymphocytic leukaemia (ARCTIC) trial.1 passage
• Clinical effectiveness and patient perspectives of different treatment strategies for tics in children and adolescents with Tourette syndrome: a systematic review and qualitative analysis.1 passage
• Clinical effectiveness, cost-effectiveness and acceptability of low-intensity interventions in the management of obsessive-compulsive disorder: the Obsessive-Compulsive Treatment Efficacy randomised controlled Trial (OCTET).1 passage
• Clinical trial metadata: defining and extracting metadata on the design, conduct, results and costs of 125 randomised clinical trials funded by the National Institute for Health Research Health Technology Assessment programme.1 passage
• Cognitive therapy compared with CBT for social anxiety disorder in adolescents: a feasibility study.1 passage
• Cognitive-behaviour therapy for health anxiety in medical patients (CHAMP): a randomised controlled trial with outcomes to 5 years.1 passage
• Cognitive-behavioural therapy and short-term psychoanalytic psychotherapy versus brief psychosocial intervention in adolescents with unipolar major depression (IMPACT): a multicentre, pragmatic, observer-blind, randomised controlled trial.1 passage
• Cognitive-behavioural therapy compared with standardised medical care for adults with dissociative non-epileptic seizures: the CODES RCT.1 passage
• Cognitive-behavioural therapy for a variety of conditions: an overview of systematic reviews and panoramic meta-analysis.1 passage
• Cognitive-behavioural therapy for clozapine-resistant schizophrenia: the FOCUS RCT.1 passage
• Cognitive-behavioural therapy-based intervention to reduce fear of falling in older people: therapy development and randomised controlled trial - the Strategies for Increasing Independence, Confidence and Energy (STRIDE) study.1 passage
• CollAborative care and active surveillance for Screen-Positive EldeRs with subthreshold depression (CASPER): a multicentred randomised controlled trial of clinical effectiveness and cost-effectiveness.1 passage
• CollAborative care for Screen-Positive EldeRs with major depression (CASPER plus): a multicentred randomised controlled trial of clinical effectiveness and cost-effectiveness.1 passage
• Collagenase clostridium histolyticum for the treatment of Dupuytren's contracture: systematic review and economic evaluation.1 passage
• Combining mirtazapine with SSRIs or SNRIs for treatment-resistant depression: the MIR RCT.1 passage
• Combining optical coherence tomography with visual field data to rapidly detect disease progression in glaucoma: a diagnostic accuracy study.1 passage
• Comparing alternating pressure mattresses and high-specification foam mattresses to prevent pressure ulcers in high-risk patients: the PRESSURE 2 RCT.1 passage
• Comparing open and minimally invasive surgical procedures for oesophagectomy in the treatment of cancer: the ROMIO (Randomised Oesophagectomy: Minimally Invasive or Open) feasibility study and pilot trial.1 passage
• Comparison Of iNfliximab and ciclosporin in STeroid Resistant Ulcerative Colitis: pragmatic randomised Trial and economic evaluation (CONSTRUCT).1 passage
• Compression stockings in addition to low-molecular-weight heparin to prevent venous thromboembolism in surgical inpatients requiring pharmacoprophylaxis: the GAPS non-inferiority RCT.1 passage
• Computed tomographic colonography compared with colonoscopy or barium enema for diagnosis of colorectal cancer in older symptomatic patients: two multicentre randomised trials with economic evaluation (the SIGGAR trials).1 passage
• Computerised interpretation of the fetal heart rate during labour: a randomised controlled trial (INFANT).1 passage
• Computerised speech and language therapy or attention control added to usual care for people with long-term post-stroke aphasia: the Big CACTUS three-arm RCT.1 passage
• Concordance in diabetic foot ulceration: a cross-sectional study of agreement between wound swabbing and tissue sampling in infected ulcers.1 passage
• Conservative treatment for uncomplicated appendicitis in children: the CONTRACT feasibility study, including feasibility RCT.1 passage
• Continuous low-dose antibiotic prophylaxis to prevent urinary tract infection in adults who perform clean intermittent self-catheterisation: the AnTIC RCT.1 passage
• Continuous subcutaneous insulin infusion versus multiple daily injections in children and young people at diagnosis of type 1 diabetes: the SCIPI RCT.1 passage
• Contrast-enhanced ultrasound and/or colour duplex ultrasound for surveillance after endovascular abdominal aortic aneurysm repair: a systematic review and economic evaluation.1 passage
• Cost and Outcome of BehaviouRal Activation (COBRA): a randomised controlled trial of behavioural activation versus cognitive-behavioural therapy for depression.1 passage
• Cost-effectiveness of non-invasive methods for assessment and monitoring of liver fibrosis and cirrhosis in patients with chronic liver disease: systematic review and economic evaluation.1 passage
• Cue-based versus scheduled feeding for preterm infants transitioning from tube to oral feeding: the Cubs mixed-methods feasibility study.1 passage
• Cultural adaptation of an existing children's weight management programme: the CHANGE intervention and feasibility RCT.1 passage
• Debt Counselling for Depression in Primary Care: an adaptive randomised controlled pilot trial (DeCoDer study).1 passage
• Dementia Care Mapping™ to reduce agitation in care home residents with dementia: the EPIC cluster RCT.1 passage
• Denosumab, raloxifene, romosozumab and teriparatide to prevent osteoporotic fragility fractures: a systematic review and economic evaluation.1 passage
• Developing a multidisciplinary rehabilitation package following hip fracture and testing in a randomised feasibility study: Fracture in the Elderly Multidisciplinary Rehabilitation (FEMuR).1 passage
• Developing a reference protocol for structured expert elicitation in health-care decision-making: a mixed-methods study.1 passage
• Developing a serocorrelate of protection against invasive group B streptococcus disease in pregnant women: a feasibility study.1 passage
• Developing and piloting a peer mentoring intervention to reduce teenage pregnancy in looked-after children and care leavers: an exploratory randomised controlled trial.1 passage
• Development and validation of Prediction models for Risks of complications in Early-onset Pre-eclampsia (PREP): a prospective cohort study.1 passage
• Development of a core outcome set for disease modification trials in mild to moderate dementia: a systematic review, patient and public consultation and consensus recommendations.1 passage
• Development of a cost-effectiveness model for optimisation of the screening interval in diabetic retinopathy screening.1 passage
• Development of processes allowing near real-time refinement and validation of triage tools during the early stage of an outbreak in readiness for surge: the FLU-CATs Study.1 passage
• DiPALS: Diaphragm Pacing in patients with Amyotrophic Lateral Sclerosis - a randomised controlled trial.1 passage
• Diagnostic accuracy of the Thessaly test, standardised clinical history and other clinical examination tests (Apley's, McMurray's and joint line tenderness) for meniscal tears in comparison with magnetic resonance imaging diagnosis.1 passage
• Different corticosteroid induction regimens in children and young people with juvenile idiopathic arthritis: the SIRJIA mixed-methods feasibility study.1 passage
• Different strategies for pharmacological thromboprophylaxis for lower-limb immobilisation after injury: systematic review and economic evaluation.1 passage
• Different temperature thresholds for antipyretic intervention in critically ill children with fever due to infection: the FEVER feasibility RCT.1 passage
• Does home oxygen therapy (HOT) in addition to standard care reduce disease severity and improve symptoms in people with chronic heart failure? A randomised trial of home oxygen therapy for patients with chronic heart failure.1 passage
• Does progesterone prophylaxis to prevent preterm labour improve outcome? A randomised double-blind placebo-controlled trial (OPPTIMUM).1 passage
• Does therapeutic writing help people with long-term conditions? Systematic review, realist synthesis and economic considerations.1 passage
• Double-blind randomised controlled trial of percutaneous tibial nerve stimulation versus sham electrical stimulation in the treatment of faecal incontinence: CONtrol of Faecal Incontinence using Distal NeuromodulaTion (the CONFIDeNT trial).1 passage
• Dual-chamber pacemakers for treating symptomatic bradycardia due to sick sinus syndrome without atrioventricular block: a systematic review and economic evaluation.1 passage
• Duration of intravenous antibiotic therapy for children with acute osteomyelitis or septic arthritis: a feasibility study.1 passage
• E-cigarettes compared with nicotine replacement therapy within the UK Stop Smoking Services: the TEC RCT.1 passage
• Early estimation of pandemic influenza Antiviral and Vaccine Effectiveness (EAVE): use of a unique community and laboratory national data-linked cohort study.1 passage
• Early versus deferred endovenous ablation of superficial venous reflux in patients with venous ulceration: the EVRA RCT.1 passage
• Early, specialist vocational rehabilitation to facilitate return to work after traumatic brain injury: the FRESH feasibility RCT.1 passage
• Educational interventions to improve quality of life in people with chronic inflammatory skin diseases: systematic reviews of clinical effectiveness and cost-effectiveness.1 passage
• Effectiveness and acceptability of parental financial incentives and quasi-mandatory schemes for increasing uptake of vaccinations in preschool children: systematic review, qualitative study and discrete choice experiment.1 passage
• Effectiveness and cost-effectiveness of serum B-type natriuretic peptide testing and monitoring in patients with heart failure in primary and secondary care: an evidence synthesis, cohort study and cost-effectiveness model.1 passage
• Effectiveness and economic evaluation of self-help educational materials for the prevention of smoking relapse: randomised controlled trial.1 passage
• Effects of antenatal diet and physical activity on maternal and fetal outcomes: individual patient data meta-analysis and health economic evaluation.1 passage
• Electronically delivered interventions to reduce antibiotic prescribing for respiratory infections in primary care: cluster RCT using electronic health records and cohort study.1 passage
• Enhanced invitation methods and uptake of health checks in primary care: randomised controlled trial and cohort study using electronic health records.1 passage
• Enhanced motivational interviewing for reducing weight and increasing physical activity in adults with high cardiovascular risk: the MOVE IT three-arm RCT.1 passage
• Enhanced psychological care in cardiac rehabilitation services for patients with new-onset depression: the CADENCE feasibility study and pilot RCT.1 passage
• Enteral lactoferrin to prevent infection for very preterm infants: the ELFIN RCT.1 passage
• Enzyme-linked immunosorbent assays for monitoring TNF-alpha inhibitors and antibody levels in people with rheumatoid arthritis: a systematic review and economic evaluation.1 passage
• Erlotinib and gefitinib for treating non-small cell lung cancer that has progressed following prior chemotherapy (review of NICE technology appraisals 162 and 175): a systematic review and economic evaluation.1 passage
• Evaluating Acupuncture and Standard carE for pregnant women with Back pain (EASE Back): a feasibility study and pilot randomised trial.1 passage
• Evaluating Long-term Outcomes of NHS Stop Smoking Services (ELONS): a prospective cohort study.1 passage
• Evaluation and validation of social and psychological markers in randomised trials of complex interventions in mental health: a methodological research programme.1 passage
• Evaluation of the effectiveness and cost-effectiveness of lightweight fibreglass heel casts in the management of ulcers of the heel in diabetes: a randomised controlled trial.1 passage
• Everolimus, lutetium-177 DOTATATE and sunitinib for advanced, unresectable or metastatic neuroendocrine tumours with disease progression: a systematic review and cost-effectiveness analysis.1 passage
• Exercise or manual physiotherapy compared with a single session of physiotherapy for osteoporotic vertebral fracture: three-arm PROVE RCT.1 passage
• Exercise programme to improve quality of life for patients with end-stage kidney disease receiving haemodialysis: the PEDAL RCT.1 passage
• Exercise- and strategy-based physiotherapy-delivered intervention for preventing repeat falls in people with Parkinson's: the PDSAFE RCT.1 passage
• Exercise-based cardiac rehabilitation for chronic heart failure: the EXTRAMATCH II individual participant data meta-analysis.1 passage
• Extended-release naltrexone versus standard oral naltrexone versus placebo for opioid use disorder: the NEAT three-arm RCT.1 passage
• Facet joint injections for people with persistent non-specific low back pain (Facet Injection Study): a feasibility study for a randomised controlled trial.1 passage
• Facet-joint injections for non-specific low back pain: a feasibility RCT.1 passage
• Faecal immunochemical tests to triage patients with lower abdominal symptoms for suspected colorectal cancer referrals in primary care: a systematic review and cost-effectiveness analysis.1 passage
• Faecal immunochemical tests versus colonoscopy for post-polypectomy surveillance: an accuracy, acceptability and economic study.1 passage
• Fall prevention interventions in primary care to reduce fractures and falls in people aged 70 years and over: the PreFIT three-arm cluster RCT.1 passage
• Feasibility and design of a trial regarding the optimal mode of delivery for preterm birth: the CASSAVA multiple methods study.1 passage
• Femtosecond laser-assisted cataract surgery compared with phacoemulsification: the FACT non-inferiority RCT.1 passage
• Financial incentives to improve adherence to antipsychotic maintenance medication in non-adherent patients: a cluster randomised controlled trial.1 passage
• Fluorouracil plasma monitoring: systematic review and economic evaluation of the My5-FU assay for guiding dose adjustment in patients receiving fluorouracil chemotherapy by continuous infusion.1 passage
• Fluoxetine to improve functional outcomes in patients after acute stroke: the FOCUS RCT.1 passage
• Framework for the development and evaluation of complex interventions: gap analysis, workshop and consultation-informed update.1 passage
• Gastrostomy versus nasogastric tube feeding for chemoradiation patients with head and neck cancer: the TUBE pilot RCT.1 passage
• Gentamicin as an alternative to ceftriaxone in the treatment of gonorrhoea: the G-TOG non-inferiority RCT.1 passage
• Glyceryl trinitrate to reduce the need for manual removal of retained placenta following vaginal delivery: the GOT-IT RCT.1 passage
• Goal-oriented cognitive rehabilitation for early-stage Alzheimer's and related dementias: the GREAT RCT.1 passage
• Graduated compression stockings for the prevention of deep-vein thrombosis in postoperative surgical patients: a systematic review and economic model with a value of information analysis.1 passage
• Group cognitive rehabilitation to reduce the psychological impact of multiple sclerosis on quality of life: the CRAMMS RCT.1 passage
• Group cognitive-behavioural programme to reduce the impact of rheumatoid arthritis fatigue: the RAFT RCT with economic and qualitative evaluations.1 passage
• Guided self-help for depression in autistic adults: the ADEPT feasibility RCT.1 passage
• HPV testing compared with routine cytology in cervical screening: long-term follow-up of ARTISTIC RCT.1 passage
• High-dose oral vitamin D supplementation and mortality in people aged 65-84 years: the VIDAL cluster feasibility RCT of open versus double-blind individual randomisation.1 passage
• High-sensitivity troponin assays for early rule-out of acute myocardial infarction in people with acute chest pain: a systematic review and economic evaluation.1 passage
• High-sensitivity troponin assays for the early rule-out or diagnosis of acute myocardial infarction in people with acute chest pain: a systematic review and cost-effectiveness analysis.1 passage
• High-throughput non-invasive prenatal testing for fetal rhesus D status in RhD-negative women not known to be sensitised to the RhD antigen: a systematic review and economic evaluation.1 passage
• Home environmental assessments and modification delivered by occupational therapists to reduce falls in people aged 65 years and over: the OTIS RCT.1 passage
• Home-based health promotion for older people with mild frailty: the HomeHealth intervention development and feasibility RCT.1 passage
• Home-based narrowband UVB, topical corticosteroid or combination for children and adults with vitiligo: HI-Light Vitiligo three-arm RCT.1 passage
• INVESTIGATE-I (INVasive Evaluation before Surgical Treatment of Incontinence Gives Added Therapeutic Effect?): a mixed-methods study to assess the feasibility of a future randomised controlled trial of invasive urodynamic testing prior to surgery for stress urinary incontinence in women.1 passage
• Imaging tests for the detection of osteomyelitis: a systematic review.1 passage
• Imiquimod versus podophyllotoxin, with and without human papillomavirus vaccine, for anogenital warts: the HIPvac factorial RCT.1 passage
• Immediate oral versus immediate topical versus delayed oral antibiotics for children with acute otitis media with discharge: the REST three-arm non-inferiority electronic platform-supported RCT.1 passage
• ImmunoCAP® ISAC and Microtest for multiplex allergen testing in people with difficult to manage allergic disease: a systematic review and cost analysis.1 passage
• Immunosuppressive therapy for kidney transplantation in adults: a systematic review and economic model.1 passage
• Immunosuppressive therapy for kidney transplantation in children and adolescents: systematic review and economic evaluation.1 passage
• Implantable cardiac monitors to detect atrial fibrillation after cryptogenic stroke: a systematic review and economic evaluation.1 passage
• Improving continence in children and young people with neurodisability: a systematic review and survey.1 passage
• Improving outcomes for people in mental health crisis: a rapid synthesis of the evidence for available models of care.1 passage
• Improving the Quality of Dentistry (IQuaD): a cluster factorial randomised controlled trial comparing the effectiveness and cost-benefit of oral hygiene advice and/or periodontal instrumentation with routine care for the prevention and management of periodontal disease in dentate adults attending dental primary care.1 passage
• Individual cognitive stimulation therapy for dementia: a clinical effectiveness and cost-effectiveness pragmatic, multicentre, randomised controlled trial.1 passage
• Individualised placement and support programme for people unemployed because of chronic pain: a feasibility study and the InSTEP pilot RCT.1 passage
• Infliximab, adalimumab and golimumab for treating moderately to severely active ulcerative colitis after the failure of conventional therapy (including a review of TA140 and TA262): clinical effectiveness systematic review and economic model.1 passage
• Initiating change locally in bullying and aggression through the school environment (INCLUSIVE): a pilot randomised controlled trial.1 passage
• Integrated sensor-augmented pump therapy systems [the MiniMed® Paradigm™ Veo system and the Vibe™ and G4® PLATINUM CGM (continuous glucose monitoring) system] for managing blood glucose levels in type 1 diabetes: a systematic review and economic evaluation.1 passage
• Interferon gamma release assays for Diagnostic Evaluation of Active tuberculosis (IDEA): test accuracy study and economic evaluation.1 passage
• International multicentre randomised controlled trial of improvisational music therapy for children with autism spectrum disorder: TIME-A study.1 passage
• Intervention Now to Eliminate Repeat Unintended Pregnancy in Teenagers (INTERUPT): a systematic review of intervention effectiveness and cost-effectiveness, and qualitative and realist synthesis of implementation factors and user engagement.1 passage
• Interventions based on early intensive applied behaviour analysis for autistic children: a systematic review and cost-effectiveness analysis.1 passage
• Interventions designed to improve therapeutic communications between black and minority ethnic people and professionals working in psychiatric services: a systematic review of the evidence for their effectiveness.1 passage
• Interventions for adults with a history of complex traumatic events: the INCiTE mixed-methods systematic review.1 passage
• Interventions for hyperhidrosis in secondary care: a systematic review and value-of-information analysis.1 passage
• Interventions to improve the mental health of children and young people with long-term physical conditions: linked evidence syntheses.1 passage
• Interventions to reduce the risk of surgically transmitted Creutzfeldt-Jakob disease: a cost-effective modelling review.1 passage
• Interventions to treat premature ejaculation: a systematic review short report.1 passage
• Intramedullary nail fixation versus locking plate fixation for adults with a fracture of the distal tibia: the UK FixDT RCT.1 passage
• Intratumoural immune signature to identify patients with primary colorectal cancer who do not require follow-up after resection: an observational study.1 passage
• Intravenous co-amoxiclav to prevent infection after operative vaginal delivery: the ANODE RCT.1 passage
• Intravenous or oral antibiotic treatment in adults and children with cystic fibrosis and Pseudomonas aeruginosa infection: the TORPEDO-CF RCT.1 passage
• Intravitreal ranibizumab versus aflibercept versus bevacizumab for macular oedema due to central retinal vein occlusion: the LEAVO non-inferiority three-arm RCT.1 passage
• Is whole-colon investigation by colonoscopy, computerised tomography colonography or barium enema necessary for all patients with colorectal cancer symptoms, and for which patients would flexible sigmoidoscopy suffice? A retrospective cohort study.1 passage
• Lamotrigine for people with borderline personality disorder: a RCT.1 passage
• Lansoprazole for persistent throat symptoms in secondary care: the TOPPITS RCT.1 passage
• Laparoscopic supracervical hysterectomy compared with second-generation endometrial ablation for heavy menstrual bleeding: the HEALTH RCT.1 passage
• Lead-I ECG for detecting atrial fibrillation in patients with an irregular pulse using single time point testing: a systematic review and economic evaluation.1 passage
• Lenvatinib and sorafenib for differentiated thyroid cancer after radioactive iodine: a systematic review and economic evaluation.1 passage
• Levetiracetam as an alternative to phenytoin for second-line emergency treatment of children with convulsive status epilepticus: the EcLiPSE RCT.1 passage
• Liver resection surgery compared with thermal ablation in high surgical risk patients with colorectal liver metastases: the LAVA international RCT.1 passage
• Low-dose computed tomography for lung cancer screening in high-risk populations: a systematic review and economic evaluation.1 passage
• Low-dose oral theophylline combined with inhaled corticosteroids for people with chronic obstructive pulmonary disease and high risk of exacerbations: a RCT.1 passage
• MRI in the diagnosis of fetal developmental brain abnormalities: the MERIDIAN diagnostic accuracy study.1 passage
• MRI versus laparoscopy to diagnose the main causes of chronic pelvic pain in women: a test-accuracy study and economic evaluation.1 passage
• Magnetic resonance enterography compared with ultrasonography in newly diagnosed and relapsing Crohn's disease patients: the METRIC diagnostic accuracy study.1 passage
• Managing Faecal INcontinence in people with advanced dementia resident in Care Homes (FINCH) study: a realist synthesis of the evidence.1 passage
• Managing diabetes in people with dementia: a realist review.1 passage
• Managing with Learning Disability and Diabetes: OK-Diabetes - a case-finding study and feasibility randomised controlled trial.1 passage
• Manualised cognitive-behavioural therapy in treating depression in advanced cancer: the CanTalk RCT.1 passage
• Mapping clinical outcomes to generic preference-based outcome measures: development and comparison of methods.1 passage
• Measurement of exhaled nitric oxide concentration in asthma: a systematic review and economic evaluation of NIOX MINO, NIOX VERO and NObreath.1 passage
• Medications for chronic obstructive pulmonary disease: a historical non-interventional cohort study with validation against RCT results.1 passage
• Metformin in non-diabetic hyperglycaemia: the GLINT feasibility RCT.1 passage
• Methods for the estimation of the National Institute for Health and Care Excellence cost-effectiveness threshold.1 passage
• Microdiscectomy compared with transforaminal epidural steroid injection for persistent radicular pain caused by prolapsed intervertebral disc: the NERVES RCT.1 passage
• Mifepristone and misoprostol versus placebo and misoprostol for resolution of miscarriage in women diagnosed with missed miscarriage: the MifeMiso RCT.1 passage
• Minimally invasive autopsy for fetuses and children based on a combination of post-mortem MRI and endoscopic examination: a feasibility study.1 passage
• Modelling disease progression in relapsing-remitting onset multiple sclerosis using multilevel models applied to longitudinal data from two natural history cohorts and one treated cohort.1 passage
• Modelling of hypothetical SARS-CoV-2 point of care tests for routine testing in residential care homes: rapid cost-effectiveness analysis.1 passage
• Modelling of hypothetical SARS-CoV-2 point-of-care tests on admission to hospital from A&E: rapid cost-effectiveness analysis.1 passage
• Modelling tool to support decision-making in the NHS Health Check programme: workshops, systematic review and co-production with users.1 passage
• Models and applications for measuring the impact of health research: update of a systematic review for the Health Technology Assessment programme.1 passage
• Modifying Alcohol Consumption to Reduce Obesity (MACRO): development and feasibility trial of a complex community-based intervention for men.1 passage
• Molecular testing for Lynch syndrome in people with colorectal cancer: systematic reviews and economic evaluation.1 passage
• Multimodal imaging interpreted by graders to detect re-activation of diabetic eye disease in previously treated patients: the EMERALD diagnostic accuracy study.1 passage
• Multiparametric MRI to improve detection of prostate cancer compared with transrectal ultrasound-guided prostate biopsy alone: the PROMIS study.1 passage
• Multiple-frequency bioimpedance devices for fluid management in people with chronic kidney disease receiving dialysis: a systematic review and economic evaluation.1 passage
• Multiplex tests to identify gastrointestinal bacteria, viruses and parasites in people with suspected infectious gastroenteritis: a systematic review and economic analysis.1 passage
• Negative-pressure wound therapy compared with standard dressings following surgical treatment of major trauma to the lower limb: the WHiST RCT.1 passage
• Negative-pressure wound therapy versus standard dressings for adults with an open lower limb fracture: the WOLLF RCT.1 passage
• Neuraminidase inhibitors for influenza: a systematic review and meta-analysis of regulatory and mortality data.1 passage
• Nicotine preloading for smoking cessation: the Preloading RCT.1 passage
• Nicotine replacement treatment, e-cigarettes and an online behavioural intervention to reduce relapse in recent ex-smokers: a multinational four-arm RCT.1 passage
• Nocturnal temperature-controlled laminar airflow device for adults with severe allergic asthma: the LASER RCT.1 passage
• Non-benzodiazepine hypnotic use for sleep disturbance in people aged over 55 years living with dementia: a series of cohort studies.1 passage
• Non-contact infrared thermometers compared with current approaches in primary care for children aged 5 years and under: a method comparison study.1 passage
• Non-invasive imaging software to assess the functional significance of coronary stenoses: a systematic review and economic evaluation.1 passage
• Non-pharmacological interventions for attention-deficit/hyperactivity disorder (ADHD) delivered in school settings: systematic reviews of quantitative and qualitative research.1 passage
• Non-pharmacological treatments for stuttering in children and adults: a systematic review and evaluation of clinical effectiveness, and exploration of barriers to successful outcomes.1 passage
• Nutritional management in newborn babies receiving therapeutic hypothermia: two retrospective observational studies using propensity score matching.1 passage
• OPTIMA prelim: a randomised feasibility study of personalised care in the treatment of women with early breast cancer.1 passage
• Observational study to estimate the changes in the effectiveness of bacillus Calmette-Guérin (BCG) vaccination with time since vaccination for preventing tuberculosis in the UK.1 passage
• Occupational advice to help people return to work following lower limb arthroplasty: the OPAL intervention mapping study.1 passage
• Ondansetron and metoclopramide as second-line antiemetics in women with nausea and vomiting in pregnancy: the EMPOWER pilot factorial RCT.1 passage
• Open urethroplasty versus endoscopic urethrotomy for recurrent urethral stricture in men: the OPEN RCT.1 passage
• Optimal strategies for monitoring lipid levels in patients at risk or with cardiovascular disease: a systematic review with statistical and cost-effectiveness modelling.1 passage
• Optimal surveillance strategies for patients with stage 1 cutaneous melanoma post primary tumour excision: three systematic reviews and an economic model.1 passage
• Oral anticoagulants for primary prevention, treatment and secondary prevention of venous thromboembolic disease, and for prevention of stroke in atrial fibrillation: systematic review, network meta-analysis and cost-effectiveness analysis.1 passage
• Oral splints for patients with temporomandibular disorders or bruxism: a systematic review and economic evaluation.1 passage
• Oral steroids for hearing loss associated with otitis media with effusion in children aged 2-8 years: the OSTRICH RCT.1 passage
• Oral versus intravenous antibiotics for bone and joint infections: the OVIVA non-inferiority RCT.1 passage
• Orthotic management of instability of the knee related to neuromuscular and central nervous system disorders: systematic review, qualitative study, survey and costing analysis.1 passage
• Outpatient physiotherapy versus home-based rehabilitation for patients at risk of poor outcomes after knee arthroplasty: CORKA RCT.1 passage
• PET-NECK: a multicentre randomised Phase III non-inferiority trial comparing a positron emission tomography-computerised tomography-guided watch-and-wait policy with planned neck dissection in the management of locally advanced (N2/N3) nodal metastases in patients with squamous cell head and neck cancer.1 passage
• PET-PANC: multicentre prospective diagnostic accuracy and health economic analysis study of the impact of combined modality 18fluorine-2-fluoro-2-deoxy-d-glucose positron emission tomography with computed tomography scanning in the diagnosis and management of pancreatic cancer.1 passage
• PLEASANT: Preventing and Lessening Exacerbations of Asthma in School-age children Associated with a New Term - a cluster randomised controlled trial and economic evaluation.1 passage
• PROMISE: first-trimester progesterone therapy in women with a history of unexplained recurrent miscarriages - a randomised, double-blind, placebo-controlled, international multicentre trial and economic evaluation.1 passage
• Palliative radiotherapy combined with stent insertion to reduce recurrent dysphagia in oesophageal cancer patients: the ROCS RCT.1 passage
• Pan-retinal photocoagulation and other forms of laser treatment and drug therapies for non-proliferative diabetic retinopathy: systematic review and economic evaluation.1 passage
• Parent-delivered interventions used at home to improve eating, drinking and swallowing in children with neurodisability: the FEEDS mixed-methods study.1 passage
• Partial ablation versus radical prostatectomy in intermediate-risk prostate cancer: the PART feasibility RCT.1 passage
• Patch augmentation surgery for rotator cuff repair: the PARCS mixed-methods feasibility study.1 passage
• Pharmacological and non-pharmacological interventions for non-respiratory sleep disturbance in children with neurodisabilities: a systematic review.1 passage
• Pharmacological and non-pharmacological treatments and outcomes for new-onset atrial fibrillation in ICU patients: the CAFE scoping review and database analyses.1 passage
• Pilot of a randomised controlled trial of the selective serotonin reuptake inhibitor sertraline versus cognitive behavioural therapy for anxiety symptoms in people with generalised anxiety disorder who have failed to respond to low-intensity psychological treatments as defined by the National Institute for Health and Care Excellence guidelines.1 passage
• Placebo comparator group selection and use in surgical trials: the ASPIRE project including expert workshop.1 passage
• Placental growth factor (alone or in combination with soluble fms-like tyrosine kinase 1) as an aid to the assessment of women with suspected pre-eclampsia: systematic review and economic analysis.1 passage
• Plaster cast versus functional bracing for Achilles tendon rupture: the UKSTAR RCT.1 passage
• Point-of-care creatinine tests to assess kidney function for outpatients requiring contrast-enhanced CT imaging: systematic reviews and economic evaluation.1 passage
• Positive behaviour support training for staff for treating challenging behaviour in people with intellectual disabilities: a cluster RCT.1 passage
• Powered mobility interventions for very young children with mobility limitations to aid participation and positive development: the EMPoWER evidence synthesis.1 passage
• Practical help for specifying the target difference in sample size calculations for RCTs: the DELTA1 passage
• Practice nurse-supported weight self-management delivered within the national child immunisation programme for postnatal women: a feasibility cluster RCT.1 passage
• Prasugrel (Efient®) with percutaneous coronary intervention for treating acute coronary syndromes (review of TA182): systematic review and economic analysis.1 passage
• Pre-hospital non-invasive ventilation for acute respiratory failure: a systematic review and cost-effectiveness evaluation.1 passage
• Preconception care for women with type 1 or type 2 diabetes mellitus: a mixed-methods study exploring uptake of preconception care.1 passage
• Prediction of risk of recurrence of venous thromboembolism following treatment for a first unprovoked venous thromboembolism: systematic review, prognostic model and clinical decision rule, and economic evaluation.1 passage
• Prehospital continuous positive airway pressure for acute respiratory failure: the ACUTE feasibility RCT.1 passage
• Prehospital randomised assessment of a mechanical compression device in out-of-hospital cardiac arrest (PARAMEDIC): a pragmatic, cluster randomised trial and economic evaluation.1 passage
• Preoperative behavioural intervention to reduce drinking before elective orthopaedic surgery: the PRE-OP BIRDS feasibility RCT.1 passage
• Preoperative intravenous iron for anaemia in elective major open abdominal surgery: the PREVENTT RCT.1 passage
• Pressure garment to prevent abnormal scarring after burn injury in adults and children: the PEGASUS feasibility RCT and mixed-methods study.1 passage
• Preventing blood-borne virus infection in people who inject drugs in the UK: systematic review, stakeholder interviews, psychosocial intervention development and feasibility randomised controlled trial.1 passage
• Primary trabeculectomy versus primary glaucoma eye drops for newly diagnosed advanced glaucoma: TAGS RCT.1 passage
• Procalcitonin testing to guide antibiotic therapy for the treatment of sepsis in intensive care settings and for suspected bacterial infection in emergency department settings: a systematic review and cost-effectiveness analysis.1 passage
• Progesterone to prevent miscarriage in women with early pregnancy bleeding: the PRISM RCT.1 passage
• Prognostic biomarkers to identify patients likely to develop severe Crohn's disease: a systematic review.1 passage
• Prognostic models for identifying risk of poor outcome in people with acute ankle sprains: the SPRAINED development and external validation study.1 passage
• Prognostic models of survival in patients with advanced incurable cancer: the PiPS2 observational study.1 passage
• Prognostic tools for identification of high risk in people with Crohn's disease: systematic review and cost-effectiveness study.1 passage
• Progressive exercise compared with best-practice advice, with or without corticosteroid injection, for rotator cuff disorders: the GRASP factorial RCT.1 passage
• Prophylactic levofloxacin to prevent infections in newly diagnosed symptomatic myeloma: the TEAMM RCT.1 passage
• Prophylactic removal of impacted mandibular third molars: a systematic review and economic evaluation.1 passage
• Protocolised Management In Sepsis (ProMISe): a multicentre randomised controlled trial of the clinical effectiveness and cost-effectiveness of early, goal-directed, protocolised resuscitation for emerging septic shock.1 passage
• Protocolised non-invasive compared with invasive weaning from mechanical ventilation for adults in intensive care: the Breathe RCT.1 passage
• Provision of information about newborn screening antenatally: a sequential exploratory mixed-methods project.1 passage
• Provision of the progestogen-only pill by community pharmacies as bridging contraception for women receiving emergency contraception: the Bridge-it RCT.1 passage
• Psychoeducation with problem-solving (PEPS) therapy for adults with personality disorder: a pragmatic randomised controlled trial to determine the clinical effectiveness and cost-effectiveness of a manualised intervention to improve social functioning.1 passage
• Psychological and psychosocial interventions for cannabis cessation in adults: a systematic review short report.1 passage
• Psychological intervention, antipsychotic medication or a combined treatment for adolescents with a first episode of psychosis: the MAPS feasibility three-arm RCT.1 passage
• Psychological interventions to improve self-management of type 1 and type 2 diabetes: a systematic review.1 passage
• Randomised controlled trial and economic analysis of an internet-based weight management programme: POWeR+ (Positive Online Weight Reduction).1 passage
• Randomised controlled trial evaluating the effectiveness and cost-effectiveness of 'Families for Health', a family-based childhood obesity treatment intervention delivered in a community setting for ages 6 to 11 years.1 passage
• Randomised controlled trial of silk therapeutic garments for the management of atopic eczema in children: the CLOTHES trial.1 passage
• Rapid antigen detection and molecular tests for group A streptococcal infections for acute sore throat: systematic reviews and economic evaluation.1 passage
• Rapid detection of health-care-associated bloodstream infection in critical care using multipathogen real-time polymerase chain reaction technology: a diagnostic accuracy study and systematic review.1 passage
• Real-time modelling of a pandemic influenza outbreak.1 passage
• Reduced exposure to vasopressors through permissive hypotension to reduce mortality in critically ill people aged 65 and over: the 65 RCT.1 passage
• Reducing bias in trials from reactions to measurement: the MERIT study including developmental work and expert workshop.1 passage
• Restricted fluid bolus versus current practice in children with septic shock: the FiSh feasibility study and pilot RCT.1 passage
• Retrograde intramedullary nail fixation compared with fixed-angle plate fixation for fracture of the distal femur: the TrAFFix feasibility RCT.1 passage
• Risk assessments and structured care interventions for prevention of foot ulceration in diabetes: development and validation of a prognostic model.1 passage
• Risk scores to guide referral decisions for people with suspected ovarian cancer in secondary care: a systematic review and cost-effectiveness analysis.1 passage
• Risk-based, 6-monthly and 24-monthly dental check-ups for adults: the INTERVAL three-arm RCT.1 passage
• Risks and benefits of psychotropic medication in pregnancy: cohort studies based on UK electronic primary care health records.1 passage
• Robot-assisted training compared with an enhanced upper limb therapy programme and with usual care for upper limb functional limitation after stroke: the RATULS three-group RCT.1 passage
• Routine gastric residual volume measurement to guide enteral feeding in mechanically ventilated infants and children: the GASTRIC feasibility study.1 passage
• Routine low-dose continuous or nocturnal oxygen for people with acute stroke: three-arm Stroke Oxygen Supplementation RCT.1 passage
• Sacral nerve stimulation versus the magnetic sphincter augmentation device for adult faecal incontinence: the SaFaRI RCT.1 passage
• Saline in acute bronchiolitis RCT and economic evaluation: hypertonic saline in acute bronchiolitis - randomised controlled trial and systematic review.1 passage
• Screening for psychological and mental health difficulties in young people who offend: a systematic review and decision model.1 passage
• Screening strategies for atrial fibrillation: a systematic review and cost-effectiveness analysis.1 passage
• Screening women aged 65 years or over for abdominal aortic aneurysm: a modelling study and health economic evaluation.1 passage
• Seal or Varnish? A randomised controlled trial to determine the relative cost and effectiveness of pit and fissure sealant and fluoride varnish in preventing dental decay.1 passage
• Selecting pregnant or postpartum women with suspected pulmonary embolism for diagnostic imaging: the DiPEP diagnostic study with decision-analysis modelling.1 passage
• Selective internal radiation therapies for unresectable early-, intermediate- or advanced-stage hepatocellular carcinoma: systematic review, network meta-analysis and economic evaluation.1 passage
• Selective laser trabeculoplasty versus drops for newly diagnosed ocular hypertension and glaucoma: the LiGHT RCT.1 passage
• Self-Management education for adults with poorly controlled epILEpsy [SMILE (UK)]: a randomised controlled trial.1 passage
• Self-management toolkit and delivery strategy for end-of-life pain: the mixed-methods feasibility study.1 passage
• Self-sampling kits to increase HIV testing among black Africans in the UK: the HAUS mixed-methods study.1 passage
• Sepsis: the LightCycler SeptiFast Test MGRADE®, SepsiTest™ and IRIDICA BAC BSI assay for rapidly identifying bloodstream bacteria and fungi - a systematic review and economic evaluation.1 passage
• Sexual health promotion in people with severe mental illness: the RESPECT feasibility RCT.1 passage
• Sexual risk reduction interventions for patients attending sexual health clinics: a mixed-methods feasibility study.1 passage
• Silver-impregnated, antibiotic-impregnated or non-impregnated ventriculoperitoneal shunts to prevent shunt infection: the BASICS three-arm RCT.1 passage
• Six versus 12 months' adjuvant trastuzumab in patients with HER2-positive early breast cancer: the PERSEPHONE non-inferiority RCT.1 passage
• Sixteen-week versus standard eight-week prednisolone therapy for childhood nephrotic syndrome: the PREDNOS RCT.1 passage
• Smoking Cessation Intervention for severe Mental Ill Health Trial (SCIMITAR): a pilot randomised control trial of the clinical effectiveness and cost-effectiveness of a bespoke smoking cessation service.1 passage
• Smoking cessation medicines and e-cigarettes: a systematic review, network meta-analysis and cost-effectiveness analysis.1 passage
• Social Stories™ to alleviate challenging behaviour and social difficulties exhibited by children with autism spectrum disorder in mainstream schools: design of a manualised training toolkit and feasibility study for a cluster randomised controlled trial with nested qualitative and cost-effectiveness components.1 passage
• Social recovery therapy for young people with emerging severe mental illness: the Prodigy RCT.1 passage
• Sodium bicarbonate to improve physical function in patients over 60 years with advanced chronic kidney disease: the BiCARB RCT.1 passage
• Spot protein-creatinine ratio and spot albumin-creatinine ratio in the assessment of pre-eclampsia: a diagnostic accuracy study with decision-analytic model-based economic evaluation and acceptability analysis.1 passage
• Standing frames for children with cerebral palsy: a mixed-methods feasibility study.1 passage
• Start2quit: a randomised clinical controlled trial to evaluate the effectiveness and cost-effectiveness of using personal tailored risk information and taster sessions to increase the uptake of the NHS Stop Smoking Services.1 passage
• Stepped approach to improving sexual function after gynaecological cancer: the SAFFRON feasibility RCT.1 passage
• Strategy of endovascular versus open repair for patients with clinical diagnosis of ruptured abdominal aortic aneurysm: the IMPROVE RCT.1 passage
• Stratified versus usual care for the management of primary care patients with sciatica: the SCOPiC RCT.1 passage
• Strengthening And stretching for Rheumatoid Arthritis of the Hand (SARAH). A randomised controlled trial and economic evaluation.1 passage
• Structured lifestyle education to support weight loss for people with schizophrenia, schizoaffective disorder and first episode psychosis: the STEPWISE RCT.1 passage
• Subcutaneous Injection of Adalimumab Trial compared with Control (SCIATiC): a randomised controlled trial of adalimumab injection compared with placebo for patients receiving physiotherapy treatment for sciatica.1 passage
• Support and Assessment for Fall Emergency Referrals (SAFER) 2: a cluster randomised trial and systematic review of clinical effectiveness and cost-effectiveness of new protocols for emergency ambulance paramedics to assess older people following a fall with referral to community-based care when appropriate.1 passage
• Supported self-management for patients with moderate to severe chronic obstructive pulmonary disease (COPD): an evidence synthesis and economic analysis.1 passage
• Surgery versus conservative management of stable thoracolumbar fracture: the PRESTO feasibility RCT.1 passage
• Surgical Trial In Traumatic intraCerebral Haemorrhage (STITCH): a randomised controlled trial of Early Surgery compared with Initial Conservative Treatment.1 passage
• Surgical fixation compared with cast immobilisation for adults with a bicortical fracture of the scaphoid waist: the SWIFFT RCT.1 passage
• Surgical interventions for uterine prolapse and for vault prolapse: the two VUE RCTs.1 passage
• Surgical treatments compared with early structured physiotherapy in secondary care for adults with primary frozen shoulder: the UK FROST three-arm RCT.1 passage
• Surgical treatments for women with stress urinary incontinence: the ESTER systematic review and economic evaluation.1 passage
• Surveillance versus ablation for incidentally diagnosed small renal tumours: the SURAB feasibility RCT.1 passage
• Switching antipsychotic medication to reduce sexual dysfunction in people with psychosis: the REMEDY RCT.1 passage
• Systematic review and economic modelling of the clinical effectiveness and cost-effectiveness of art therapy among people with non-psychotic mental health disorders.1 passage
• Systematic review of interventions for treating or preventing antipsychotic-induced tardive dyskinesia.1 passage
• Systematic review of tools to measure outcomes for young children with autism spectrum disorder.1 passage
• Systematic review, meta-analysis and economic modelling of molecular diagnostic tests for antibiotic resistance in tuberculosis.1 passage
• TRAPEZE: a randomised controlled trial of the clinical effectiveness and cost-effectiveness of chemotherapy with zoledronic acid, strontium-89, or both, in men with bony metastatic castration-refractory prostate cancer.1 passage
• Tackling obesity in areas of high social deprivation: clinical effectiveness and cost-effectiveness of a task-based weight management group programme - a randomised controlled trial and economic evaluation.1 passage
• Temporarily quadrupling the dose of inhaled steroid to prevent asthma exacerbations: FAST.1 passage
• Ten-year follow-up of a randomised trial of drainage, irrigation and fibrinolytic therapy (DRIFT) in infants with post-haemorrhagic ventricular dilatation.1 passage
• Testing strategies for Lynch syndrome in people with endometrial cancer: systematic reviews and economic evaluation.1 passage
• The 4 'A's test for detecting delirium in acute medical patients: a diagnostic accuracy study.1 passage
• The AMBER care bundle for hospital inpatients with uncertain recovery nearing the end of life: the ImproveCare feasibility cluster RCT.1 passage
• The Age of BLood Evaluation (ABLE) randomised controlled trial: description of the UK-funded arm of the international trial, the UK cost-utility analysis and secondary analyses exploring factors associated with health-related quality of life and health-care costs during the 12-month follow-up.1 passage
• The Ankle Injury Management (AIM) trial: a pragmatic, multicentre, equivalence randomised controlled trial and economic evaluation comparing close contact casting with open surgical reduction and internal fixation in the treatment of unstable ankle fractures in patients aged over 60 years.1 passage
• The Arabin pessary to prevent preterm birth in women with a twin pregnancy and a short cervix: the STOPPIT 2 RCT.1 passage
• The Arthroplasty Candidacy Help Engine tool to select candidates for hip and knee replacement surgery: development and economic modelling.1 passage
• The Asymptomatic Carotid Surgery Trial-2 (ACST-2): an ongoing randomised controlled trial comparing carotid endarterectomy with carotid artery stenting to prevent stroke.1 passage
• The Cannabinoid Use in Progressive Inflammatory brain Disease (CUPID) trial: a randomised double-blind placebo-controlled parallel-group multicentre trial and economic evaluation of cannabinoids to slow progression in multiple sclerosis.1 passage
• The Clots in Legs Or sTockings after Stroke (CLOTS) 3 trial: a randomised controlled trial to determine whether or not intermittent pneumatic compression reduces the risk of post-stroke deep vein thrombosis and to estimate its cost-effectiveness.1 passage
• The Diagnosis of Urinary Tract infection in Young children (DUTY): a diagnostic prospective observational study to derive and validate a clinical algorithm for the diagnosis of urinary tract infection in children presenting to primary care with an acute illness.1 passage
• The Effectiveness, cost-effectiveness and acceptability of Community versus Hospital Eye Service follow-up for patients with neovascular age-related macular degeneration with quiescent disease (ECHoES): a virtual randomised balanced incomplete block trial.1 passage
• The Head Injury Transportation Straight to Neurosurgery (HITS-NS) randomised trial: a feasibility study.1 passage
• The HubBLe Trial: haemorrhoidal artery ligation (HAL) versus rubber band ligation (RBL) for symptomatic second- and third-degree haemorrhoids: a multicentre randomised controlled trial and health-economic evaluation.1 passage
• The INTRABEAM® Photon Radiotherapy System for the adjuvant treatment of early breast cancer: a systematic review and economic evaluation.1 passage
• The London Exercise And Pregnant smokers (LEAP) trial: a randomised controlled trial of physical activity for smoking cessation in pregnancy with an economic evaluation.1 passage
• The Men's Safer Sex project: intervention development and feasibility randomised controlled trial of an interactive digital intervention to increase condom use in men.1 passage
• The PAndemic INfluenza Triage in the Emergency Department (PAINTED) pilot cohort study.1 passage
• The ProFHER (PROximal Fracture of the Humerus: Evaluation by Randomisation) trial - a pragmatic multicentre randomised controlled trial evaluating the clinical effectiveness and cost-effectiveness of surgical compared with non-surgical treatment for proximal fracture of the humerus in adults.1 passage
• The Protease Inhibitor Monotherapy Versus Ongoing Triple Therapy (PIVOT) trial: a randomised controlled trial of a protease inhibitor monotherapy strategy for long-term management of human immunodeficiency virus infection.1 passage
• The Role of Ultrasound Compared to Biopsy of Temporal Arteries in the Diagnosis and Treatment of Giant Cell Arteritis (TABUL): a diagnostic accuracy and cost-effectiveness study.1 passage
• The TOMMY trial: a comparison of TOMosynthesis with digital MammographY in the UK NHS Breast Screening Programme--a multicentre retrospective reading study comparing the diagnostic performance of digital breast tomosynthesis and digital mammography with digital mammography alone.1 passage
• The UK EndoVascular Aneurysm Repair (EVAR) randomised controlled trials: long-term follow-up and cost-effectiveness analysis.1 passage
• The UK Lung Cancer Screening Trial: a pilot randomised controlled trial of low-dose computed tomography screening for the early detection of lung cancer.1 passage
• The West Midlands ActiVe lifestyle and healthy Eating in School children (WAVES) study: a cluster randomised controlled trial testing the clinical effectiveness and cost-effectiveness of a multifaceted obesity prevention intervention programme targeted at children aged 6-7 years.1 passage
• The assessment and appraisal of regenerative medicines and cell therapy products: an exploration of methods for review, economic evaluation and appraisal.1 passage
• The clinical effectiveness and cost-effectiveness of STeroids Or Pentoxifylline for Alcoholic Hepatitis (STOPAH): a 2 × 2 factorial randomised controlled trial.1 passage
• The clinical effectiveness and cost-effectiveness of abatacept, adalimumab, etanercept and tocilizumab for treating juvenile idiopathic arthritis: a systematic review and economic evaluation.1 passage
• The clinical effectiveness and cost-effectiveness of cetuximab (review of technology appraisal no. 176) and panitumumab (partial review of technology appraisal no. 240) for previously untreated metastatic colorectal cancer: a systematic review and economic evaluation.1 passage
• The clinical effectiveness and cost-effectiveness of heated humidified high-flow nasal cannula compared with usual care for preterm infants: systematic review and economic evaluation.1 passage
• The clinical effectiveness and cost-effectiveness of open mesh repairs in adults presenting with a clinically diagnosed primary unilateral inguinal hernia who are operated in an elective setting: systematic review and economic evaluation.1 passage
• The clinical effectiveness and cost-effectiveness of point-of-care tests (CoaguChek system, INRatio2 PT/INR monitor and ProTime Microcoagulation system) for the self-monitoring of the coagulation status of people receiving long-term vitamin K antagonist therapy, compared with standard UK practice: systematic review and economic evaluation.1 passage
• The clinical effectiveness and cost-effectiveness of telephone triage for managing same-day consultation requests in general practice: a cluster randomised controlled trial comparing general practitioner-led and nurse-led management systems with usual care (the ESTEEM trial).1 passage
• The clinical effectiveness and cost-effectiveness of the PROGENSA® prostate cancer antigen 3 assay and the Prostate Health Index in the diagnosis of prostate cancer: a systematic review and economic evaluation.1 passage
• The clinical effectiveness and cost-effectiveness of treat-to-target strategies in rheumatoid arthritis: a systematic review and cost-effectiveness analysis.1 passage
• The clinical effectiveness and cost-effectiveness of treatments for idiopathic pulmonary fibrosis: a systematic review and economic evaluation.1 passage
• The clinical effectiveness of different surveillance strategies to prevent colorectal cancer in people with intermediate-grade colorectal adenomas: a retrospective cohort analysis, and psychological and economic evaluations.1 passage
• The clinical effectiveness of individual behaviour change interventions to reduce risky sexual behaviour after a negative human immunodeficiency virus test in men who have sex with men: systematic and realist reviews and intervention development.1 passage
• The cost-effectiveness of domiciliary non-invasive ventilation in patients with end-stage chronic obstructive pulmonary disease: a systematic review and economic evaluation.1 passage
• The cost-effectiveness of testing strategies for type 2 diabetes: a modelling study.1 passage
• The effect of statins on muscle symptoms in primary care: the StatinWISE series of 200 N-of-1 RCTs.1 passage
• The effectiveness and cost-effectiveness of diversion and aftercare programmes for offenders using class A drugs: a systematic review and economic evaluation.1 passage
• The effectiveness and cost-effectiveness of erythropoiesis-stimulating agents (epoetin and darbepoetin) for treating cancer treatment-induced anaemia (including review of technology appraisal no. 142): a systematic review and economic model.1 passage
• The effectiveness and cost-effectiveness of mindfulness-based cognitive therapy compared with maintenance antidepressant treatment in the prevention of depressive relapse/recurrence: results of a randomised controlled trial (the PREVENT study).1 passage
• The effectiveness, acceptability and cost-effectiveness of psychosocial interventions for maltreated children and adolescents: an evidence synthesis.1 passage
• The feasibility of a randomised controlled trial of physiotherapy for adults with joint hypermobility syndrome.1 passage
• The feasibility of determining the effectiveness and cost-effectiveness of medication organisation devices compared with usual care for older people in a community setting: systematic review, stakeholder focus groups and feasibility randomised controlled trial.1 passage
• The feasibility of early pulmonary rehabilitation and activity after COPD exacerbations: external pilot randomised controlled trial, qualitative case study and exploratory economic evaluation.1 passage
• The future for diagnostic tests of acute kidney injury in critical care: evidence synthesis, care pathway analysis and research prioritisation.1 passage
• The identification and treatment of women with hyperglycaemia in pregnancy: an analysis of individual participant data, systematic reviews, meta-analyses and an economic evaluation.1 passage
• The impact of Cochrane Reviews: a mixed-methods evaluation of outputs from Cochrane Review Groups supported by the National Institute for Health Research.1 passage
• The impact of the National Institute for Health Research Health Technology Assessment programme, 2003-13: a multimethod evaluation.1 passage
• The management of Otitis Media with Effusion in children with cleft palate (mOMEnt): a feasibility study and economic evaluation.1 passage
• The natural history of Chlamydia trachomatis infection in women: a multi-parameter evidence synthesis.1 passage
• The prognostic utility of tests of platelet function for the detection of 'aspirin resistance' in patients with established cardiovascular or cerebrovascular disease: a systematic review and economic evaluation.1 passage
• The relationship between pelvic vein incompetence and chronic pelvic pain in women: systematic reviews of diagnosis and treatment effectiveness.1 passage
• The relative clinical effectiveness and cost-effectiveness of three contrasting approaches to partner notification for curable sexually transmitted infections: a cluster randomised trial in primary care.1 passage
• The second Randomised Evaluation of the Effectiveness, cost-effectiveness and Acceptability of Computerised Therapy (REEACT-2) trial: does the provision of telephone support enhance the effectiveness of computer-delivered cognitive behaviour therapy? A randomised controlled trial.1 passage
• The use of exploratory analyses within the National Institute for Health and Care Excellence single technology appraisal process: an evaluation and qualitative analysis.1 passage
• The use of fibrin sealant during non-emergency surgery: a systematic review of evidence of benefits and harms.1 passage
• The use of measures of obesity in childhood for predicting obesity and the development of obesity-related diseases in adulthood: a systematic review and meta-analysis.1 passage
• Therapeutic hypothermia to reduce intracranial pressure after traumatic brain injury: the Eurotherm3235 RCT.1 passage
• Therapist telephone-delivered CBT and web-based CBT compared with treatment as usual in refractory irritable bowel syndrome: the ACTIB three-arm RCT.1 passage
• Therapy interventions for children with neurodisabilities: a qualitative scoping study.1 passage
• Thoracoscopy and talc poudrage compared with intercostal drainage and talc slurry infusion to manage malignant pleural effusion: the TAPPS RCT.1 passage
• Three biomarker tests to help diagnose preterm labour: a systematic review and economic evaluation.1 passage
• Three wound-dressing strategies to reduce surgical site infection after abdominal surgery: the Bluebelle feasibility study and pilot RCT.1 passage
• Thulium laser transurethral vaporesection versus transurethral resection of the prostate for benign prostatic obstruction: the UNBLOCS RCT.1 passage
• Tibial nerve stimulation compared with sham to reduce incontinence in care home residents: ELECTRIC RCT.1 passage
• Timing of surgical intervention for developmental dysplasia of the hip: a randomised controlled trial (Hip 'Op).1 passage
• Topotecan, pegylated liposomal doxorubicin hydrochloride, paclitaxel, trabectedin and gemcitabine for advanced recurrent or refractory ovarian cancer: a systematic review and economic evaluation.1 passage
• Total hip replacement and surface replacement for the treatment of pain and disability resulting from end-stage arthritis of the hip (review of technology appraisal guidance 2 and 44): systematic review and economic evaluation.1 passage
• Total versus partial knee replacement in patients with medial compartment knee osteoarthritis: the TOPKAT RCT.1 passage
• Training nurses in a competency framework to support adults with epilepsy and intellectual disability: the EpAID cluster RCT.1 passage
• Tranexamic acid to improve functional status in adults with spontaneous intracerebral haemorrhage: the TICH-2 RCT.1 passage
• Tranexamic acid to reduce head injury death in people with traumatic brain injury: the CRASH-3 international RCT.1 passage
• Treatment of childhood anxiety disorder in the context of maternal anxiety disorder: a randomised controlled trial and economic analysis.1 passage
• Treatment of extravasation injuries in infants and young children: a scoping review and survey.1 passage
• Treatment of first-time traumatic anterior shoulder dislocation: the UK TASH-D cohort study.1 passage
• Treatments for dry age-related macular degeneration and Stargardt disease: a systematic review.1 passage
• Treatments for hyperemesis gravidarum and nausea and vomiting in pregnancy: a systematic review and economic assessment.1 passage
• Triple versus guideline antiplatelet therapy to prevent recurrence after acute ischaemic stroke or transient ischaemic attack: the TARDIS RCT.1 passage
• Tumour necrosis factor-α inhibitors for ankylosing spondylitis and non-radiographic axial spondyloarthritis: a systematic review and economic evaluation.1 passage
• Tumour profiling tests to guide adjuvant chemotherapy decisions in early breast cancer: a systematic review and economic analysis.1 passage
• Two interferon gamma release assays for predicting active tuberculosis: the UK PREDICT TB prognostic test study.1 passage
• Two speeds of increasing milk feeds for very preterm or very low-birthweight infants: the SIFT RCT.1 passage
• UK DRAFFT: a randomised controlled trial of percutaneous fixation with Kirschner wires versus volar locking-plate fixation in the treatment of adult patients with a dorsally displaced fracture of the distal radius.1 passage
• UK FASHIoN: feasibility study of a randomised controlled trial of arthroscopic surgery for hip impingement compared with best conservative care.1 passage
• UNderstanding uptake of Immunisations in TravellIng aNd Gypsy communities (UNITING): a qualitative interview study.1 passage
• Unicompartmental compared with total knee replacement for patients with multimorbidities: a cohort study using propensity score stratification and inverse probability weighting.1 passage
• Universal late pregnancy ultrasound screening to predict adverse outcomes in nulliparous women: a systematic review and cost-effectiveness analysis.1 passage
• Urodynamics tests for the diagnosis and management of bladder outlet obstruction in men: the UPSTREAM non-inferiority RCT.1 passage
• Use of drug therapy in the management of symptomatic ureteric stones in hospitalised adults: a multicentre, placebo-controlled, randomised controlled trial and cost-effectiveness analysis of a calcium channel blocker (nifedipine) and an alpha-blocker (tamsulosin) (the SUSPEND trial).1 passage
• Uterotonic drugs to prevent postpartum haemorrhage: a network meta-analysis.1 passage
• Vaccine effectiveness of live attenuated and trivalent inactivated influenza vaccination in 2010/11 to 2015/16: the SIVE II record linkage study.1 passage
• Validation and development of models using clinical, biochemical and ultrasound markers for predicting pre-eclampsia: an individual participant data meta-analysis.1 passage
• Varenicline versus nicotine replacement therapy for long-term smoking cessation: an observational study using the Clinical Practice Research Datalink.1 passage
• Venous access devices for the delivery of long-term chemotherapy: the CAVA three-arm RCT.1 passage
• Vertebral artery stenting to prevent recurrent stroke in symptomatic vertebral artery stenosis: the VIST RCT.1 passage
• Virtual chromoendoscopy for the real-time assessment of colorectal polyps in vivo: a systematic review and economic evaluation.1 passage
• Viscoelastic point-of-care testing to assist with the diagnosis, management and monitoring of haemostasis: a systematic review and cost-effectiveness analysis.1 passage
• Vitamin D supplementation to prevent acute respiratory infections: individual participant data meta-analysis.1 passage
• VivaScope® 1500 and 3000 systems for detecting and monitoring skin lesions: a systematic review and economic evaluation.1 passage
• What carcinoembryonic antigen level should trigger further investigation during colorectal cancer follow-up? A systematic review and secondary analysis of a randomised controlled trial.1 passage
• What is the added value of ultrasound joint examination for monitoring synovitis in rheumatoid arthritis and can it be used to guide treatment decisions? A systematic review and cost-effectiveness analysis.1 passage
• What is the clinical effectiveness and cost-effectiveness of conservative interventions for tendinopathy? An overview of systematic reviews of clinical effectiveness and systematic review of economic evaluations.1 passage
• What works to increase attendance for diabetic retinopathy screening? An evidence synthesis and economic analysis.1 passage
• Which method is best for the induction of labour? A systematic review, network meta-analysis and cost-effectiveness analysis.1 passage
• Whole-body MRI compared with standard pathways for staging metastatic disease in lung and colorectal cancer: the Streamline diagnostic accuracy studies.1 passage
• Youth social behaviour and network therapy (Y-SBNT): adaptation of a family and social network intervention for young people who misuse alcohol and drugs - a randomised controlled feasibility trial.1 passage