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Introduction Diverticular disease is commonly seen in older individuals in the western countries and usually involves left side of the colon. The pathogenesis of diverticular disease is thought to be multifactorial and include both environmental and genetic factors in addition to the historically accepted etiology of dietary fiber deficiency, disordered motility or structural changes of the colon [1, 2]. The disease prevalence increases with age and approximately 65% of the western population has diverticulosis by age of 85 [3-5]. Previous studies have reported that less than 10% of populations younger than 40 years of age have diverticulosis [6]. More recent studies have reported increasing incidence of diverticulosis and diverticulitis in the younger populations [7, 8]. Life style changes and obesity in addition to low dietary fiber predispose the young population towards colonic diverticulosis [9-13]. Role of vitamin D deficiency in pathogenesis of acute diverticulitis remains conjuncture [14].

creasing incidence of diverticulosis and diverticulitis in the younger populations [7, 8]. Life style changes and obesity in addition to low dietary fiber predispose the young population towards colonic diverticulosis [9-13]. Role of vitamin D deficiency in pathogenesis of acute diverticulitis remains conjuncture [14]. Majority of the younger population with diverticulosis never develops symptoms, but around 10-25% suffers from episodes of diverticulitis [15, 16]. Diverticulitis has a wide range of clinical severity ranging from mild abdominal pain to the development of acute abdomen due to perforation and peritonitis [17]. Clinical course and outcomes of diverticulitis in the younger populations have evolved overtime in the reported studies. Initial studies have described a severe clinical presentation with more complications [1, 2, 10, 18-21]. However, some recent studies have reported milder clinical outcomes which are not different from the older population [7, 17, 22]. There are no definitive guidelines regarding the management of acute diverticulitis in the young population [7, 23-25]. Most practices follow the same guidelines as for older population. Here we report a rare case of acute right-sided diverticulitis in a 20-year-old man.

Majority of the younger population with diverticulosis never develops symptoms, but around 10-25% suffers from episodes of diverticulitis [15, 16]. Diverticulitis has a wide range of clinical severity ranging from mild abdominal pain to the development of acute abdomen due to perforation and peritonitis [17]. Clinical course and outcomes of diverticulitis in the younger populations have evolved overtime in the reported studies. Initial studies have described a severe clinical presentation with more complications [1, 2, 10, 18-21]. However, some recent studies have reported milder clinical outcomes which are not different from the older population [7, 17, 22]. There are no definitive guidelines regarding the management of acute diverticulitis in the young population [7, 23-25]. Most practices follow the same guidelines as for older population. Here we report a rare case of acute right-sided diverticulitis in a 20-year-old man. Case Report A 20-year-old Middle Eastern man presented to the emergency department with 3-day history of abdominal pain in the epigastric area, radiating to the right lower quadrant, associated with diarrhea and nausea. Diarrhea was watery brown stool without blood or mucus. He denies any history of fever. Patient smoked few cigarettes per day. On initial examination in the emergency department, patient was afebrile, in mild distress due to pain with stable vital signs. His abdominal examination revealed mild tenderness in the right lower abdominal quadrant without any peritoneal signs. Rest of the review of systems and physical examination was unremarkable. Laboratory tests are discussed in Table 1. Stool examination was negative for Clostridium difficile and occult blood testing.

s. His abdominal examination revealed mild tenderness in the right lower abdominal quadrant without any peritoneal signs. Rest of the review of systems and physical examination was unremarkable. Laboratory tests are discussed in Table 1. Stool examination was negative for Clostridium difficile and occult blood testing. Table 1 Initial Relevant Laboratory Values on Presentation Laboratory test Result (normal range), day 1 Result (normal range), day 2 Hemoglobin 14.8 g/dL (12 - 16g/dL) 13.5 g/dL (12 - 16g/dL) Hematocrit 42.5% (42-51%) 39.2% (42-51%) Leukocyte count 7,100/µL (4,800 - 10,800/µL) 6,100/µL (4,800 - 10,800/µL) Platelet count 259,000/µL (150,000 - 400,000/µL) 228,000/µL (150,000 - 400,000/µL) Blood urea nitrogen 13 mg/dL (8 - 26 mg/dL) 9 mg/dL (8 - 26 mg/dL) Serum creatinine 0.8 mg/dL (0.5 - 1.5 mg/dL) 0.7 mg/dL (0.5 - 1.5mg/dL) Serum albumin 3.9 g/dL (3.2 - 4.6 g/dL) Serum total bilirubin 1.0 mg/dL (0.2 - 1.1 mg/dL) Alkaline phosphatase 207 U/L (43 - 160 U/L) Serum alanine aminotransferase 15 U/L (5 - 40 U/L) Serum aspartate transaminase 12 U/L (9 - 36 U/L) C-reactive protein 72 mg/dL (< 5 mg/dL) Ultrasound of the abdomen showed non-visualization of the appendix. Computed tomography (CT) scan of abdomen with intravenous contrast revealed scattered diverticula throughout the colon with focal thickening, pericolonic infiltrative changes suggestive of acute diverticulitis in the distal ascending colon and normal appendix. This is elaborated in Figure 1.

ualization of the appendix. Computed tomography (CT) scan of abdomen with intravenous contrast revealed scattered diverticula throughout the colon with focal thickening, pericolonic infiltrative changes suggestive of acute diverticulitis in the distal ascending colon and normal appendix. This is elaborated in Figure 1. Figure 1 CT of the abdomen and pelvis with coronal (a) and sagittal (b) sections, green arrow pointing to the diverticulae and the red arrow pointing to thickened bowel wall. Patient was admitted to pediatric floor and started intravenous hydration and antibiotics. He received intravenous cefoxitin 1 g every 6 h and oral metronidazole 500 mg every 8 h. He was kept without any oral intake till his nausea and pain improved. When he was able to tolerate oral diet, he was discharged on oral antibiotics. A month later he was seen in the gastroenterology clinic, where he reported that he was symptom free. He underwent colonoscopy which showed pan diverticulosis. Patient was advised to follow high fiber diet and quit smoking. Discussion In the last two decades, the incidence of diverticulitis in the population younger than 40 years of age have been increasingly reported but it is extremely rare in very young individuals such as our patient [1, 26]. To our knowledge this is the first case of acute diverticulitis in a young adult man. Previously similar age case was reported in a woman of the same age.

ulitis in the population younger than 40 years of age have been increasingly reported but it is extremely rare in very young individuals such as our patient [1, 26]. To our knowledge this is the first case of acute diverticulitis in a young adult man. Previously similar age case was reported in a woman of the same age. There is an increasing incidence of diverticular disease in the younger population and its occurrence in very young individual is concerning. Etzioni et al reported that more patients are diagnosed and treated for diverticulitis in recent years as compared to past [26]. This may be due to the more frequent use of CT scan aiding in the diagnoses, in addition to the clinical presentation. Comparing the disease statistics of 2005 with 1998, there was notable 26% increase in rates of hospitalization for acute disease, and a 38% increase in the rates of elective surgeries for diverticulitis in general population. In the younger population (age 18 to 44 years), there was even more profoundly increased rates of hospital admission (by 82%) and elective surgeries (by 73%) [26]. Right-sided diverticulosis is commonly seen in Asian countries and is largely associated with genetic predispositions [1]. It has been speculated that hypoganglionosis or aganglionosis are causative etiology for the pathogenesis of right-sided diverticulitis [27]. Increasing incidence of diverticular disease in other parts of world could be due their adoption of Western life style and diet.

gely associated with genetic predispositions [1]. It has been speculated that hypoganglionosis or aganglionosis are causative etiology for the pathogenesis of right-sided diverticulitis [27]. Increasing incidence of diverticular disease in other parts of world could be due their adoption of Western life style and diet. Diverticulosis is thought to occur due to multiple factors including low fiber intake, disordered colonic motility, structural abnormalities in the colon and genetic factors [1, 28, 29]. Many recent trials have reported obesity as a risk factor leading to higher incidence of diverticulitis and its related complications especially in younger men [10, 11, 13, 30]. Obesity was also reported to be significantly associated with diverticular complication such as bleeding, perforation, and recurrent diverticulitis in young male population [10, 31, 32]. Pisanu et al also demonstrated significant association of acute diverticulitis in young male patients with a BMI ≥ 25 and chronic consumption of alcohol in terms of moderate and occasionally excessive doses [9]. Nonsteroidal anti-inflammatory drugs (NSAIDs) and aspirin use also has been reported to be associated with diverticulitis [33].

emonstrated significant association of acute diverticulitis in young male patients with a BMI ≥ 25 and chronic consumption of alcohol in terms of moderate and occasionally excessive doses [9]. Nonsteroidal anti-inflammatory drugs (NSAIDs) and aspirin use also has been reported to be associated with diverticulitis [33]. Abdominal CT scan with oral and intravenous contrast is the test of choice to diagnose acute diverticulitis with high sensitivity (93-96%) and specificity (100%) [34]. It also helps in assessing the severity of inflammation, and therefore categorizes the diverticulitis into complicated or uncomplicated disease [34, 35], as well as excluding other pathology as a cause of abdominal pain. Fever (≥ 38 °C) on admission predicts increased risk of complications from acute diverticulitis in patients under 40 years of age [32].

ity of inflammation, and therefore categorizes the diverticulitis into complicated or uncomplicated disease [34, 35], as well as excluding other pathology as a cause of abdominal pain. Fever (≥ 38 °C) on admission predicts increased risk of complications from acute diverticulitis in patients under 40 years of age [32]. Due to rarity of the disease, the clinical outcomes and severity of acute diverticulitis in younger patients have not been clearly defined yet. Previously acute diverticulitis in younger patients was considered an aggressive diseases and surgical treatment was recommended to prevent recurrent attacks [2, 5]. Subsequently other studies recommended management in younger patients less than 40 years of age to be similar to the older age group. Some studies mentioned that recurrent attacks of acute diverticulitis and management occur with similar frequency in all age groups and respond equally to medical treatments [33, 36]. The risk of severe disease and complications is comparable among older and younger patients [7, 8]. However, other studies have found severe disease and increased recurrent episodes of diverticulitis in young patients as compared to older patients and also younger patients requiring more surgical interventions comparatively [3, 26, 33]. Few cases of acute diverticulitis are only diagnosed when operated for suspected appendicitis [37].

dies have found severe disease and increased recurrent episodes of diverticulitis in young patients as compared to older patients and also younger patients requiring more surgical interventions comparatively [3, 26, 33]. Few cases of acute diverticulitis are only diagnosed when operated for suspected appendicitis [37]. We reviewed our own institution admission data for acute diverticulitis over past 10 years. Among 1,800 patients with acute diverticulitis diagnosis, there were only two adolescents [38] (18 and 19 years of age). The youngest adult patient was our case reported here. Review of literature has revealed approximately eight cases in adolescents [19, 21, 39-42] and three in pediatric population [39]. Acute diverticulitis is not routinely considered in differential diagnosis when evaluating pediatric, adolescent or very young adult patients. With rising incidence of this disease, it is important that clinician consider this as a possible diagnosis when evaluating a patient with symptoms of lower abdominal pain. Appendicitis and the ovarian torsion should be in the differential diagnosis of acute diverticulitis or appendicitis in the appropriate clinical settings [1, 37].

idence of this disease, it is important that clinician consider this as a possible diagnosis when evaluating a patient with symptoms of lower abdominal pain. Appendicitis and the ovarian torsion should be in the differential diagnosis of acute diverticulitis or appendicitis in the appropriate clinical settings [1, 37]. The management of acute diverticulitis in the young can be similar to the older patients [16, 43]. Recent literature suggests that indication for surgery for acute diverticulitis should not be only based on age or number of episodes of diverticulitis [36]. Antibiotics are the mainstay of treatment for uncomplicated diverticulitis. The latest guidelines suggest selective, rather than routine use of antibiotics in patients with acute diverticulitis [36]. Conclusions Acute right-sided diverticulitis is extremely rare in young adult population. The clinical presentation is often misleading as symptoms are similar to acute appendicitis which is much more common in this age group. Severity of acute diverticulitis guides the management strategies. There are no consensus guidelines regarding number of recurrent attacks and need for elective surgical management. Our case illustrates the importance of considering acute diverticulitis in the differential diagnosis of right lower quadrant pain when evaluating a young patient. None to declare. Financial Disclosure None of the authors have any financial conflicts of interest. Conflict of Interest None to declare. Informed Consent Informed consent was obtained from this patient.

Conclusions Acute right-sided diverticulitis is extremely rare in young adult population. The clinical presentation is often misleading as symptoms are similar to acute appendicitis which is much more common in this age group. Severity of acute diverticulitis guides the management strategies. There are no consensus guidelines regarding number of recurrent attacks and need for elective surgical management. Our case illustrates the importance of considering acute diverticulitis in the differential diagnosis of right lower quadrant pain when evaluating a young patient. None to declare. Financial Disclosure None of the authors have any financial conflicts of interest. Conflict of Interest None to declare. Informed Consent Informed consent was obtained from this patient. Author Contributions MUK: conception and design, drafting of manuscript; AB: conception and design, drafting of manuscript; BB: conception and design, final approval of manuscript. All Authors have made contributions to the article and have reviewed it before submission.