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abstractpubmed· Abstract 2021· item PMID:34352197
SARS-CoV-2 Variants in Immunocompromised Patient Given Antibody Monotherapy. A 72-year-old immunocompromised man infected with severe acute respiratory syndrome coronavirus 2 received bamlanivimab monotherapy. Viral evolution was monitored in nasopharyngeal and blood samples by melting curve analysis of single-nucleotide polymorphisms and whole-genome sequencing. Rapid emergence of spike receptor binding domain mutations was found, associated with a compartmentalization of viral populations.