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abstractpubmed· Abstract 2020· item PMID:32441621

Fatal Encephalitis Caused by Cristoli Virus, an Emerging Orthobunyavirus, France. We report the discovery of a new orthobunyavirus, Cristoli virus, by means of shotgun metagenomics. The virus was identified in an immunodepressed patient with fatal encephalitis. Full-length genome sequencing revealed high-level expression of a virulence factor, possibly explaining the severity of the infection. The patient's recent history suggests circulation in France.