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abstractpubmed· Abstract 2018· item PMID:30124404
Correlation of Severity of Human Tick-Borne Encephalitis Virus Disease and Pathogenicity in Mice. We compared 2 tick-borne encephalitis virus strains isolated from 2 different foci that cause different symptoms in tick-borne encephalitis patients, from neurologic to mild gastrointestinal symptoms. We compared neuroinvasiveness, neurovirulence, and proinflammatory cytokine response in mice and found unique differences that contribute to our understanding of pathogenesis.