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==== Front Emerg Infect DiseidEmerging Infectious Diseases1080-60401080-6059Centers for Disease Control 11294718Research ArticleHIV postexposure prophylaxis in the 21st century. Henderson D. K. Warren G. Magnuson Clinical Center, Bethesda, Maryland, USA. dkh.nih.govMar-Apr 2001 7 2 254 258 The administration of postexposure prophylaxis has become the standard of care for occupational exposures to HIV. We have learned a great deal about the safety and potential efficacy of these agents, as well as the optimal management of health-care workers occupationally exposed to HIV. This article describes the current state of knowledge in this field, identifies substantive questions to be answered, and summarizes basic principles of postexposure management.