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TOWARD THE OPTIMAL SNP RESEARCH PANEL IN IRRITABLE BOWEL SYNDROME. The genetic component of multifactorial diseases which include irritable bowel syndrome (1rS) is provided by single nucgetie polmporphism (oNf mliastousual. it is essential to detect the associations of polymorphisms with various patholo- nucleotide are not as us. It cs esed for diagnostic purposes and the development of drug therapies. Analyses of individual polymorphisms have not found their unique relationship with susceptibility to IS. Possibly, several genetic risk factors, together with the influence of the environment cause a synergistic effect leading to the appearance of IgS certain phenotype. This paper presents a research panel of five SNP, which are hereditary factors for violations processes of innate immunity: CD14-159 C> T (rs2569190); TNFa -308 G> A (rs1800629); IL17A -197 G> A (rs2275913); TLR2 Arg753GIn G> A (rs5743708); TLR4 Asp299Gly A> G (rs4986790). Results indicate genetically determined predisposition to l13S as the number of "rare" alleles in the test regions of genes CD14, TNF- and TLR4. Carriage heterozygous genotype GA polymorphism IL17A -197 G>A is also a risk factor for IS in the population studied. On the contrary, carriage of "rare" allele polymorphism Arg753GIn G>A TLR2 gene has to be protective, but normal - predictive properties in the context of the development of lBS.