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Extracorporeal Gas Exchange: The Expanding Role of Extracorporeal Support in Respiratory Failure. The use of extracorporeal support is expanding quickly in adult respiratory failure. Extracorporeal gas exchange is an accepted rescue therapy for severe acute respiratory distress syndrome (ARDS) in select patients. Extracorporeal carbon dioxide removal is also being investigated as a preventative, preemptive, and management platform in patients with respiratory failure other than severe ARDS. The non-ARDS patient population is much larger, so the potential for rapid growth is high. This article hopes to inform decisions about the use of extracorporeal support by increasing understanding concerning the past and present practice of extracorporeal gas exchange.