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abstractpubmed· Abstract 2015· item PMID:26621294

Pemberton Sign: A Recommendation to Perform Arm Elevation Spirometry With Flow-Volume Loops. We report a case of intrathoracic goiter with positive Pemberton sign. Conventional spirometry did not show abnormalities, but arm elevation spirometry with flow-volume loops revealed expiratory flow limitation with a plateau. Clinicians should consider repeating flow-volume loops with arm elevation in all cases of intrathoracic goiter with initially normal loops.