Browse the corpus

s and renal function improved markedly after bilateral ureteral stenting. To date there have been just two case reports of obstructive uropathy associated with OHSS [9, 10]. We therefore suggest that obstructive uropathy should also be considered as a possible etiology in patients with OHSS who develop oliguria or ARF. Conflict of Interests The authors have no conflict of interests to declare. Acknowledgments The study has not been presented in any form in any meeting or forum. This paper is not under consideration in any other journal. The authors declare that there was no funding for this study. All authors have read the manuscript and agreed to the content. Figure 1 Ultrasound images showing enlarged right and left ovaries with multiple peripherally enlarged follicles. (a) Right ovary measuring 18 × 14 × 11 cm3, (b) left ovary measuring 17 × 12 × 12 cm3, and (c) computed tomography of the abdomen and pelvis showing bilateral enlarged multilocular and cystic ovaries.

1. Introduction OHSS is a potentially life-threatening complication of ovulation induction. The syndrome is characterized by the presence of enlarged ovaries (due to enlarged follicles) and an acute shift of protein-rich fluid out of the vascular compartment. This syndrome occurs almost exclusively during assisted reproductive technology (ART) cycles, although cases occurring after ovarian stimulation using clomiphene citrate, spontaneous pregnancy (especially molar pregnancy and multiple pregnancies), and mutations involving FSH receptors have been described [1, 2]. Various mediators have been implicated in the pathogenesis of OHSS; these include interleukins (IL1, IL2, IL6, IL8, endothelin 1, TNF-alpha), prostaglandins and renin angiotensin aldosterone system, and vascular endothelial growth factor (VEGF) [3].

es), and mutations involving FSH receptors have been described [1, 2]. Various mediators have been implicated in the pathogenesis of OHSS; these include interleukins (IL1, IL2, IL6, IL8, endothelin 1, TNF-alpha), prostaglandins and renin angiotensin aldosterone system, and vascular endothelial growth factor (VEGF) [3]. 2. Case Report The patient is a 30-year-old obese African-American female, with no significant past medical history who had been married for three years but was nulliparous. She presented with a two-day history of nausea, vomiting, diffuse abdominal pain, abdominal distension, and lower extremity edema. She recently underwent ovulation induction with follicle stimulating hormone and recombinant human chorionic gonadotropin with retrieval of oocytes (8 in total) which was performed just two days prior to her admission. On examination, she was noted to be in moderate distress with a blood pressure of 86/56 mm Hg, heart rate of 110/minute, and respiratory rate of 26/minute with oxygen saturation of 98% on 2 L oxygen. Her abdomen was distended with diffuse tenderness and guarding with evidence of ascites but without peritoneal signs. Her beta-human chorionic gonadotropin (βhCG) was negative and her initial estradiol level was 21,000 pg/mL. Her chest roentgenogram showed normal cardiac silhouette, without any infiltrates or effusions. A diagnosis of severe life-threatening OHSS was made and she was started on IV albumin (25 gm/100 mL) and vasopressors (epinephrine 4 mcg/min) in the intensive care unit (ICU). Bedside abdominal ultrasound showed markedly enlarged ovaries (right ovary 18 × 14 × 11 cm3, left ovary 17 × 12 × 12 cm3) abutting each other at the middle, with multiple peripherally enlarged follicles with good arterial and venous flow signals and moderate amount of ascites and bilateral small pleural effusions (Figures 1(a) and 1(b)). Computed tomography of the abdomen and pelvis showed bilateral enlarged multilocular and cystic ovaries touching each other at the middle with multiple dependent intracystic crescents and truncal edema (Figure 1(c)). Her intra-abdominal pressure (IAP) was elevated at 28 mmHg and she subsequently underwent therapeutic paracentesis under ultrasound guidance with a net removal of 1500 cc of serosanguinous fluid. Her symptoms transiently improved after the paracentesis but the repeat intra-abdominal pressure was still elevated at 24 mm Hg.

intra-abdominal pressure (IAP) was elevated at 28 mmHg and she subsequently underwent therapeutic paracentesis under ultrasound guidance with a net removal of 1500 cc of serosanguinous fluid. Her symptoms transiently improved after the paracentesis but the repeat intra-abdominal pressure was still elevated at 24 mm Hg. Her renal function progressively worsened with blood urea nitrogen (BUN) and creatinine levels peaking at 46 mg/dL and 4 mg/dL, respectively, on the 5th ICU day. Her body weight increased from 78 Kg on admission to 98 Kg on the 5th ICU day. Repeat ultrasound of the abdomen and pelvis on the 6th ICU day revealed interval increase in the size of the ovaries (right ovary: 25 × 12 × 25 cm3, left ovary: 22 × 11 × 17 cm3), with good arterial and venous flow signals, mild ascites, and evidence of hydroureter and hydronephrosis in the left kidney; right kidney appeared to be apparently normal. On ICU day 7, she underwent cystoscopy with retrograde bilateral ureteral stenting and ultrasound-guided aspiration of bilateral ovaries (500 cc of fluid removed). Her symptoms and renal function progressively improved and she was eventually discharged home on hospital day 14.

t kidney appeared to be apparently normal. On ICU day 7, she underwent cystoscopy with retrograde bilateral ureteral stenting and ultrasound-guided aspiration of bilateral ovaries (500 cc of fluid removed). Her symptoms and renal function progressively improved and she was eventually discharged home on hospital day 14. 3. Discussion OHSS is classified as either an early onset OHSS (occurring within 9 days after oocyte retrieval and is related to hyperresponsiveness of the ovaries to gonadotropin stimulation and exogenous hCG) or as a late onset OHSS (appears after this 10-day period and is associated with hCG produced by an implanted embryo) [4, 5]. OHSS can cause a rapid accumulation of volume (from 1.5 to 17 liters) in the peritoneal cavity that can lead to organ dysfunction, including respiratory impairment and oliguria [6]. OHSS causes the ovaries to enlarge and when combined with ascites can overwhelm the compliance of the abdominal wall thereby elevating the intra-abdominal pressure to the point of causing an abdominal compartment syndrome (ACS) [7, 8]. In spite of frequent occurrence of ACS and oliguria in OHSS, acute renal failure secondary to obstructive uropathy is uncommon in OHSS. This patient had severe OHSS that resulted in ascites, ACS, pleural effusions, anasarca, and hypotension. All of these factors could have potentially contributed to oliguria and ARF, but the patient had evidence of obstruction on ultrasound and her symptoms and renal function improved markedly after bilateral ureteral stenting. To date there have been just two case reports of obstructive uropathy associated with OHSS [9, 10]. We therefore suggest that obstructive uropathy should also be considered as a possible etiology in patients with OHSS who develop oliguria or ARF.