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BACKGROUND: Prediabetes is a pivotal risk factor for developing diabetes. This meta-analysis was performed to assess the global prevalence of childhood prediabetes. METHODS: A systematic search was conducted for studies of prediabetes prevalence in the general pediatric population from inception until December 2021. Random-effects meta-analysis was used to combine the data. Variations in the prevalence estimates in different subgroups (age group, sex, setting, investigation period, body mass index [BMI] group, family history of diabetes, diagnosis criteria, World Health Organization [WHO] and World Bank [WB] regions) were examined by subgroup meta-analysis. RESULTS: A total of 48 studies were included in the meta-analysis. The pooled prevalence was 8.84% (95% CI, 6.74%-10.95%) for prediabetes in childhood. Subgroup meta-analyses showed that the prevalence was higher in males than females (8.98% vs 8.74%, P < .01), in older compared to younger children (7.56% vs. 2.51%, p < 0.01), in urban compared to rural areas (6.78% vs. 2.47, p < 0.01), and higher in children with a family history of diabetes than in those without such a history (7.59% vs. 6.80%, p < 0.01). We observed an upward trend in prediabetes prevalence from 0.93% to 10.66% over past decades (p < 0.01). The pooled prevalence increased from 7.64% to 14.27% with increased BMI (p < 0.01). Pooled prevalence was the lowest for criterion A among different diagnosis criteria (p < 0.01). For WHO and WB regions, the European Region and high-income countries yielded the lowest pooled prevalence (p < 0.01). CONCLUSIONS: Elevated prediabetes prevalence in childhood reaches an alarming level. Intensive lifestyle modification is needed to improve the prediabetes epidemic. 背景: 前期糖尿病是糖尿病发生的关键危险因素。这项荟萃分析旨在评估全球儿童前期糖尿病的患病率。 方法: 对从研究开始到2021年12月的普通儿科人群中前期糖尿病患病率的研究进行了系统搜索。采用随机效应荟萃分析数据。通过亚组meta分析检查不同亚组(年龄组、性别、环境、调查周期、体重指数(BMI)、糖尿病家族史、诊断标准、世界卫生组织和世界银行地区)患病率估计值的差异。 结果: 共有48项研究被纳入meta分析。儿童前期糖尿病的综合患病率为8.84% (95% CI, 6.74%-10.95%)。亚组meta分析显示，男性患病率高于女性(8.98% vs. 8.74%，P<0.01)，大龄儿童患病率高于低龄儿童(7.56% vs. 2.51%，P<0.01)，城市儿童患病率高于农村儿童(6.78% vs. 2.47,P<0.01)，有糖尿病家族史儿童患病率高于无糖尿病家族史儿童(7.59% vs. 6.80%，P<0.01)。我们观察到在过去的几十年中，糖尿病前期患病率从0.93%上升到10.66% (P<0.01)。随着BMI的增加，合并患病率从7.64%上升到14.27%(P<0.01)。在不同诊断标准中，A标准(FPG = 6.1-7.0 mmol/L)合并患病率最低(P<0.01)。就世卫组织和世界银行地区而言，欧洲区域和高收入国家的总患病率最低(P<0.01)。 结论: 儿童前期糖尿病患病率升高达到了一个惊人的水平。需要加强生活方式的改变来改善前期糖尿病的流行。.